EP0150732A2
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EP
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Phospholipid-emulsified prostaglandin compostion
Assignee: Tanabe Pharma Corp
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Filing: 1985-01-11
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Granted: —
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Expires: 2005-01-11
Abstract
Abstract A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidylethanolamine-free phospholipid, the composition being suitable for intravenous administration.
Inventors
- 👤 Takashi Imagawa
- 👤 Kazumasa Yokoyama
- 👤 Yutaka Mizushima
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 02:44
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; A61K31/00; A61K31/557; A61P; A61P43/00
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
13 words
A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidyl-ethanolamine- free phospholipid.
Claim 2
Dependent Claim
13 words
A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidyl-ethanolamine- free phospholipid.
Claim 3
Dependent Claim
42 words
The composition according to Claim 1, wherein said prostaglandin is selected from the group consisting of PGF 2a , PGE 2 , PGD 2 PGF 1α , PGE 1 , PGA I , PGI 2 , PGB 1 and the derivatives thereof.
Claim 4
Dependent Claim
15 words
The composition according to Claim 2, wherein said derivatives are the alkyl esters of prostaglandins.
Claim 5
Dependent Claim
64 words
The composition according to Claim 1, wherein said composition consists essentially of (a) an oil component, (b) a phospholipid component, and (c) water, the proportion of said oil component (a) being about 5 to 50 w/v percent of the total composition and the proportion of said phospholipid component (b) being about 1 to about 50 parts per 100 parts of said oil component (a).
Claim 6
Dependent Claim
23 words
The composition according to Claim 1, wherein the proportion of the oil component is 8 to 30 w/v percent of the total emulsion.
Claim 7
Dependent Claim
26 words
The composition according to Claim 4, wherein the proportion of said phospholipid component is 5 to 30 parts per 100 parts of said oil component (a).
Claim 8
Dependent Claim
14 words
The composition according to Claim 4, wherein said composition further contains an auxiliary emulsifier.
Claim 9
Dependent Claim
26 words
The composition according to Claim 7, wherein said auxiliary emulsifier is a fatty acid having 6 to 22 carbon atoms or a physiologically acceptable salt thereof.
Claim 10
Dependent Claim
16 words
The composition according to Claim 8, wherein said fatty acid has 12 to 20 carbon atoms.
Claim 11
Dependent Claim
23 words
The composition according to Claim 7, wherein said fatty acid is present in a proportion of not more than about 0.3 w/v percent.
Claim 12
Dependent Claim
37 words
The composition according to Claim 4, 5 or 6, wherein said composition further contains one or more of a member selected from the group consisting of a stabilizer, a high molecular weight compound, and an isotonifying agent.
Claim 13
Dependent Claim
42 words
The composition according to Claim 11, wherein said stabilizer is selected from the group consisting of a cholesterol compound in a proportion of not more than 0.5 w/v percent, and phosphatidic acid in a proportion of not more than 5 w/v percent.
Claim 14
Dependent Claim
38 words
The composition according to Claim 11, wherein said cholesterol compound is present in a proportion of not more than 0.1 w/v percent and said phosphatidic acid is present in a proportion of not more than 1 w/v percent.
Claim 15
Dependent Claim
48 words
A composition according to Claim 11, wherein said high molecular compound is selected from the group consisting of albumin, dextran, a vinyl polymer, a nonionic surfactant, gelatin and hydroxyethyl-starch in a proportion of 0.1 to 5 weight parts relative to 1 weight part of prostaglandin in the composition.
Claim 16
Dependent Claim
28 words
The composition according to Claim 11, wherein the proportion of said member is 0.5 to 1 weight part relative to 1 weight part of prostaglandin in the composition.
Claim 17
Dependent Claim
14 words
The composition according to Claim 11, wherein said isotonifying agent is glycerin or glucose.
Claim 18
Dependent Claim
16 words
The composition according to Claim 1, wherein said composition contains 0.2 to 100 ug of prostaglandin.
Claim 19
Dependent Claim
14 words
The composition according to Claim 4, wherein said oil component is a vegetable oil.
Claim 20
Dependent Claim
31 words
The composition according to Claim 18, wherein said vegetable oil is a member selected from the group consisting of soybean oil, cotton seed oil, sesame oil, safflower oil and corn oil.
Claim 21
Dependent Claim
24 words
The composition according to Claim 19, wherein said oil component is a high purity soybean oil obtained by steam distillation of purified soybean oil.
Claim 22
Dependent Claim
33 words
The composition according to Claim 1, wherein said phosphatidylethanolamine-free phospholipid is a phospholipid fraction obtained from egg yolk or soybean by fractionation with an organic acid and subsequent purification with an inorganic adsorbent.
Claim 23
Dependent Claim
16 words
The composition according to Claims 1 or 21, wherein said phosphatidylethanolamine-free phosphlipid consists predominantly of phosphatidylcholine.
Claim 24
Dependent Claim
12 words
The composition according to Claim 13, wherein said albumin is human albumin.
Claim 25
Dependent Claim
14 words
The prostaglandin emulsion composition according to Claim 14, wherein said vinyl polymer is polyvinylpyrrolidone.
Claim 26
Dependent Claim
29 words
The composition according to Claim 14, wherein said nonionic surfactant is selected from the group consisting of polyalkylene glycols, polyoxyalkylene copolymers, hydrogenated castor oil-polyoxyalkylene derivatives and castor oil-polyoxyethylene derivatives.
Claim 27
Dependent Claim
72 words
The composition according to Claim 25, wherein said polyoxyalkylene copolymers have an average molecular weight of about 1,000 to about 10,000, said polyoxyalkylene copolymers have an average molecular weight of about 1,000 to about 20,000, said hydrogenated castor oil-polyoxyalkylene derivatives are selected from the group consisting of hydrogenated castor oil-polyoxyethylene (40)-ether, (20)-ether and (100)-ether, and said castor oil-polyoxyalkylene derivatives are selected from the group consisting of castor oil-polyoxyethylene (20)-ether, (40)-ether and (100)-ether.
References Cited (Backward Citations)
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