EP0142732A2
Expired / Lapsed
EP
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Pheophorbide derivatives and pharmaceutical preparations containing them
Assignee: Toyo Hakka Kogyo Co Ltd
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Filing: 1984-10-23
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Granted: —
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Expires: 2004-10-23
Abstract
Abstract The subject matter of the invention are pheophorbide derivatives and their alkali metal salt of the general formulas I, Ia and II according to the patent claims. The compounds of the invention are useful in cancer treatment.
Inventors
- 👤 Isao Sakata
- 👤 Susumu Nakajima
- 👤 Koichi Koshimizu
- 👤 Natsuki Samejima
- 👤 Kazumi Inohara
- 👤 Hiroyuki Takata
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 00:01
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22; C07D519/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
27 words
Pheophorbide derivatives and alkali metal salts thereof represented by the general formula I and their dimers and alkali metal salts thereof represented by the general formula II
Claim 2
Dependent Claim
27 words
Pheophorbide derivatives and alkali metal salts thereof represented by the general formula I and their dimers and alkali metal salts thereof represented by the general formula II
Claim 3
Dependent Claim
73 words
wherein R 1 represents CH=CH 2 , or R 2 represents CH 3 , CHO or CH 2 0H, R 3 represents C=O, OH or OCOCH 3 , R 4 represents H, COOCH 3 , COOCH 2 -CH 2 0H COOCH 2 CH 2 0COCH 3 or COONH- residue of amino acid, and R 5 represents COOH, COONa or COOCH 3 ; privided, however, said derivatives and alkaline salts exclude pheophorbide and pyropheophorbide.
Claim 4
Dependent Claim
73 words
wherein R 1 represents CH=CH 2 , or R 2 represents CH 3 , CHO or CH 2 0H, R 3 represents C=O, OH or OCOCH 3 , R 4 represents H, COOCH 3 , COOCH 2 -CH 2 0H COOCH 2 CH 2 0COCH 3 or COONH- residue of amino acid, and R 5 represents COOH, COONa or COOCH 3 ; privided, however, said derivatives and alkaline salts exclude pheophorbide and pyropheophorbide.
Claim 5
Dependent Claim
42 words
9-Desoxo-9-hydroxy-pheophorbide derivatives and alkali salts thereof represented by the general formula Ia wherein R 2 represents CH 3 or CH 2 0H, R 6 represents H or Ac, and R 7 represents H or an alkali metal such as Na and K.
Claim 6
Dependent Claim
42 words
9-Desoxo-9-hydroxy-pheophorbide derivatives and alkali salts thereof represented by the general formula Ia wherein R 2 represents CH 3 or CH 2 0H, R 6 represents H or Ac, and R 7 represents H or an alkali metal such as Na and K.
Claim 7
Dependent Claim
24 words
Pheophorbide derivatives having the general formula I, Ia or II as claimed in claims 1 or 2 for use in the treatment of cancer.
Claim 8
Dependent Claim
26 words
Pharmaceutical compositions containing a pheophorbide derivative having the general formula I, Ia or II as claimed in claims 1 or 2 and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
No citation records indexed.
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