Bone substitute material based on natural bone

Abstract

Abstract The bone substitute material on the base of natural bone is rendered completely free of albumin and antigen by premaceration, pyrolization and sintering and its frame work consists of only the natural mineral structure of the natural bone. In the process of production of this bone substitute material the bone pieces are submitted to a pretreatment with warm water for removing of the soft parts, subsequently takes place a dealbumination by means of a solution of 10 to 30% H2O2 in a shaking machine and a degreasing with ether. The bone pieces treated in this way are subsequently submitted to a combustion in a stove at 400 DEG C. to 1500 DEG C. and then to a sintering. This bone substitute material which may exist in the shape of the bone part to be replaced forms a form stable matrix for the bone regeneration in which only pure "mineral bone" is present so that no immunogen reactions can take place. The process which includes combustion and sintering is considerably shorter than known processes.

Inventors

• 👤 Heinz Prof. Dr. Med. Mittelmeier
• 👤 Bernhard Mittelmeier
• 👤 Beat Leu

Bibliographic Details