Purine derivatives, their application in anti-viral compositions

Abstract

Abstract Compounds of the formula and the pharmaceutically acceptable salts thereof are disclosed. In these compounds, R 1 is halogen, -SR 4 wherein R 4 is H or alkyl of 1 to 4 carbon atoms, - OCH 3 , - OSO 2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms, -NR 4 R 5 wherein R 4 is as defined above and R 5 is H, alkyl of 1 to 4 carbon atoms, amino, alkanoyl of 1 to 8 carbon atoms, benzoyl, methoxy or hydroxy or R 1 is - N(CH 3 ) 3 + X - wherein X is halogen or -OSO 2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms; R 2 is H, alkanoyl of 1 to 8 carbon atoms or benzoyl; R 3 is A or B wherein A is wherein R 6 and R 7 are independently selected from wherein R 6 and R 9 are independently selected from pharmaceutically acceptable cations and H, H, or R 6 and R 7 taken together are wherein R 10 is selected from pharmaceutically acceptable cations and H; with the proviso that R 4 is not H when: R S is H, R 3 is A, and R 6 and R 7 are H. The compounds have anti-viral activity.

Inventors

• 👤 Richard L. Tolman
• 👤 Wallace Ashton
• 👤 Malcolm Maccoss

Bibliographic Details