Patent US3288729A successfully refreshed from Google Patents.
EP0134318A2
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EP
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Controlled release of injectable and implantable insulin compositions
Assignee: Sanofi Pasteur Ltd
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Filing: 1983-06-22
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Granted: —
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Expires: 2003-06-22
Abstract
Abstract Long lasting injectable and implantable insulin compositions are provided in the form of an insulin-biodegradable polymer matrix. The biodegradable polymer is preferably a lactic acid polymer and may be provided in the form of microbeads or pellets.
Inventors
- 👤 Mattheus Florentius Albertus Goosen
- 👤 Anthony Mein-Fang Sun
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 14:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/28; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
17 words
A biodegradable composition suitable for administration to a body, characterized by insulin and a biodegradable polymer matrix.
Claim 2
Dependent Claim
17 words
A biodegradable composition suitable for administration to a body, characterized by insulin and a biodegradable polymer matrix.
Claim 3
Dependent Claim
16 words
The composition claimed in claim 1, characterized in that the polymer is a lactic acid polymer.
Claim 4
Dependent Claim
28 words
The composition claimed in claim 2, characterized in that the lactic acid polymer has a molecular weight of 3 x 10 4 to 1 x 10 6 .
Claim 5
Dependent Claim
28 words
The composition . claimed in claim 3, characterized in that the lactic acid polymer has a molecular weight of 5 x 10 to 1 x 10 5 .
Claim 6
Dependent Claim
21 words
The composition claimed in any one of claims 2 to 4, characterized in that the lactic acid polymer is polylactic acid.
Claim 7
Dependent Claim
33 words
The composition claimed in any one of claims 2 to 5, characterized in that the lactic acid polymer is a copolymer of lactic acid and glycolic acid containing 10 to 90wt.% lactic acid.
Claim 8
Dependent Claim
24 words
The composition claimed in any one of claims 1 to 6, characterized in that the insulin comprises 5 to 60% w/w of the composition.
Claim 9
Dependent Claim
24 words
The composition claimed in any one of claims 1 to 7, characterized by the physical form of microbeads of diameter 10 to 300 µm.
Claim 10
Dependent Claim
18 words
The composition claimed in any one of claims 1 to 7, characterized by the physical form of pellets.
Claim 11
Dependent Claim
30 words
The composition claimed in claim 9, characterized in that the pellets are cylindrical, have a length of 2 to 15 mm and have a thickness of 1 to 5 mm.
Claim 12
Dependent Claim
52 words
A process for the preparation of a biodegradable composition useful for the control of blood sugar levels in a body, characterized by mixing powdered insulin with a solution of a biodegradable polymer in a volatile organic solvent for the polymer, and removing the solvent to provide a polymer matrix containing the insulin.
Claim 13
Dependent Claim
52 words
A process for the preparation of a biodegradable composition useful for the control of blood sugar levels in a body, characterized by mixing powdered insulin with a solution of a biodegradable polymer in a volatile organic solvent for the polymer, and removing the solvent to provide a polymer matrix containing the insulin.
Claim 14
Dependent Claim
47 words
The process claimed in claim 11, characterized by emulsifying an organic suspension of the polymer, volatile organic solvent and insulin in a continuous aqueous phase, evaporating the organic solvent to form a suspension of microbeads in the aqueous phase, and filtering the microbeads from the aqueous phase.
Claim 15
Dependent Claim
42 words
The process claimed in claim 11, characterized by pouring an organic suspension of the polymer, volatile organic solvent and insulin into a mold, evaporating the organic solvent to form a solid pellet in the mold, and removing the pellet from the mold.
Claim 16
Independent Claim
21 words
A method of forming a biodegradable composition suitable for administration to a body, characterized by distributing insulin throughout a biodegradable polymer.
Claim 17
Independent Claim
21 words
A method of forming a biodegradable composition suitable for administration to a body, characterized by distributing insulin throughout a biodegradable polymer.
Claim 18
Dependent Claim
16 words
The method claimed in claim 1, characterized in that the polymer is a lactic acid polymer.
Claim 19
Dependent Claim
28 words
The method claimed in claim 2, characterized in that the lactic acid polymer has a molecular weight of 3 x 10 4 to 1 x 10 6 .
Claim 20
Dependent Claim
28 words
The method claimed in claim 3, characterized in that the lactic acid polymer has a molecular weight of 5 x 10 4 to 1 x 10 5 .
Claim 21
Independent Claim
21 words
The method claimed in any one of claims 2 to 4, characterized in that the lactic acid polymer is polylactic acid.
Claim 22
Independent Claim
33 words
The method claimed in any one of claims 2 to 5, characterized in that the lactic acid polymer is a copolymer of lactic acid and glycolic acid containing 10 to 90wt.% lactic acid.
Claim 23
Independent Claim
24 words
The method claimed in any one of claims 1 to 6, characterized in that the insulin comprises 5 to 60% w/w of the composition.
Claim 24
Independent Claim
41 words
The method claimed in any one of claims 1 to 7, characterized in that the insulin is mixed in powdered form with a solution of the biodegradable polymer in a volatile organic solvent for the polymer and the solvent is removed.
Claim 25
Dependent Claim
41 words
The method claimed in claim 8, characterized in that an organic suspension of the polymer, solvent and insulin is emulsified in a continuous aqueous phase and removal of the solvent by evaporation forms a suspension of microbeads in the aqueous phase.
Claim 26
Dependent Claim
19 words
The method claimed in claim 9, characterized in that the microbeads have a diameter of 10 to 300 pm.
Claim 27
Dependent Claim
44 words
The method claimed in claim 8, characterized in that an organic suspension of the polymer, solvent and insulin is poured into a mold, removal of the solvent by evaporation forms a solid pellet in the mold, and the pellet is removed from the mold.
Claim 28
Dependent Claim
29 words
The method claimed in claim 11, characterized in that the pellets are cylindrical, have a length of 2 to 15 mm and a thickness of 1 to 5 mm.
References Cited (Backward Citations)
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