EP0133376A1
Expired / Lapsed
EP
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Synthetic analgesic and/or anti-inflammatory derivatives of manoalide
Assignee: University of California Berkeley
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Filing: 1984-08-03
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Granted: —
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Expires: 2004-08-03
Abstract
Abstract Manoalide derivatives of formula (1): wherein X is and Y is a hydrogen atom, or X is and Y is a hydroxyl or acetoxy group, or X is and Y is a hydroxyl group are useful as analgesics and/or anti-inflammatory agents.
Inventors
- 👤 Robert S. Jacobs
- 👤 John D. Faulkner
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 23:38
CPC Classifications
C; C07; C07D; C07D407/00; C07D407/02; C07D407/04; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D307/58; C07D307/60
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
35 words
A manoalide derivative of formula (I): wherein X is and Y is a hydrogen atom, or X is and Y is a hydroxyl or acetoxy group, or X is and Y is a hydroxyl group.
Claim 2
Dependent Claim
35 words
A manoalide derivative of formula (I): wherein X is and Y is a hydrogen atom, or X is and Y is a hydroxyl or acetoxy group, or X is and Y is a hydroxyl group.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 which is 3,7-bis(hydroxymethyl-4-hydroxy-ll-methyl-13-(2',6',6'-trimethylcyclohexenyl)-2,6,10-tridecatrienoic acid δ-lactone.
Claim 4
Dependent Claim
10 words
A compound according to claim 1 which is manoalide δ-lactone.
Claim 5
Dependent Claim
11 words
A compound according to claim 1 which is manoalide δ-lactone acetate.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is manoalide dehydromanoalide.
Claim 7
Dependent Claim
18 words
A process for the preparation of 3,7-bis(hydroxymethyl)-4-hydroxy-11-methyl-13-(2',6',6'-trimethylcyclohexenyl)-2,6,10-tridecatrienoic acid δ-lactone, which process comprises reacting manoalide with excess sodium borohydride.
Claim 8
Dependent Claim
18 words
A process for the preparation of 3,7-bis(hydroxymethyl)-4-hydroxy-11-methyl-13-(2',6',6'-trimethylcyclohexenyl)-2,6,10-tridecatrienoic acid δ-lactone, which process comprises reacting manoalide with excess sodium borohydride.
Claim 9
Dependent Claim
37 words
A process for the preparatyion of manoalide 8-lactone or manoalide δ-lactone acetate, which process comprises reacting manoalide with Jones' reagent and, if desired, reacting the manoalide δ-lactone thus produced with acetic anhydride to form manoalide δ-lactone acetate.
Claim 10
Dependent Claim
37 words
A process for the preparatyion of manoalide 8-lactone or manoalide δ-lactone acetate, which process comprises reacting manoalide with Jones' reagent and, if desired, reacting the manoalide δ-lactone thus produced with acetic anhydride to form manoalide δ-lactone acetate.
Claim 11
Dependent Claim
15 words
A process for the preparation of dehydromanoalide, which process comprises the acid-catalysed dehydration of manoalide.
Claim 12
Dependent Claim
15 words
A process for the preparation of dehydromanoalide, which process comprises the acid-catalysed dehydration of manoalide.
Claim 13
Dependent Claim
27 words
A pharmaceutical composition comprising, as active ingredient, a compound as claimed in any one of claims 1 to 5 together with a pharmaceutically acceptable additive or excipient.
Claim 14
Dependent Claim
4 words
Synthetic analogs of manoalide.
Claim 15
Dependent Claim
4 words
Synthetic analogs of manoalide.
References Cited (Backward Citations)
AT362873B
Cited
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