EP0133234A2
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EP
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Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds
Assignee: Daiichi Pharmaceutical Co Ltd
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Filing: 1984-07-13
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Granted: —
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Expires: 2004-07-13
Abstract
Abstract Imidazoquinazolin-2-one compounds having platelet aggregation inhibitory activity is disclosed. These compounds have high water-solubility and reduced influences on the circulatory system and are useful for treatment and prophylaxis of intravascular thromboembolism and temporary ischemia as well as prevention of thrombus upon use of prosthetic apparatus.
Inventors
- 👤 Fumiyoshi Daiichi Seiyaku Research Lab. Ishikawa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 06:37
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/135; A; A61; A61P; A61P35/00; A61P7/00; A61P7/02; C07C; C07C255/00; C07D239/00; C07D239/70; C07D239/72; C07D239/95; C07D239/96; C07D295/14; C07D295/155; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
93 words
Imidazoquinazolin-2-one compounds of the general formula (I): wherein R 1 represents a di-lower alkylamino group having 1 to 6 carbon atoms in its alkyl moiety, a cyclic amino group or a substituted cyclic amino group; and R 2 represents a hydrogen atom, a halogen atom, a lower alkyl group having 1 to 6 carbon atoms or a lower alkoxy group having 1 to 6 carbon atoms, with proviso that the case wherein R 1 is a 7-piperidino group and R 2 is a hydrogen atom is excluded, and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
93 words
Imidazoquinazolin-2-one compounds of the general formula (I): wherein R 1 represents a di-lower alkylamino group having 1 to 6 carbon atoms in its alkyl moiety, a cyclic amino group or a substituted cyclic amino group; and R 2 represents a hydrogen atom, a halogen atom, a lower alkyl group having 1 to 6 carbon atoms or a lower alkoxy group having 1 to 6 carbon atoms, with proviso that the case wherein R 1 is a 7-piperidino group and R 2 is a hydrogen atom is excluded, and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
46 words
An imidazoquinazoline compound as claimed in Claim 1, wherein the cyclic amino group is a 1-pyrrolidinyl group, a 1-piperidinyl group, a 1-piperazinyl group or a 4-morpholinyl group, and the substituted amino group is a 4-methyl-1-piperazinyl group, a 4-methyl-1-piperidinyl group, a 2-methyl-1-piperidinyl group or a 3,5-dimethyl-1-piperidinyl group.
Claim 4
Dependent Claim
71 words
A process for preparingth e . imidazoquinazoiin-2-one compounds of the general formula (I) of claims 1 or 2 which comprises reacting a compound represented by the formula (II) : wherein R 1 and R 2 are as defined above; and R 3 represents a lower alkyl group having 1 to 6 carbon atoms, with ammonia in the presence of a solvent at a temperature of from about 100°C to about 150°C.
Claim 5
Dependent Claim
72 words
A process for preparing theimidazoquinazolin-2-one compounds of the general formula (I) of claims 1 or 2 which comprises reacting a compound represented by the formula (III): wherein R1 and R2 are defined above; and R 3 represents a lower alkyl group having 1 to 6 carbon atoms, with a cyanogen halide or N-amidinopyrazole in a solvent under reflux or at room temperature, followed by treating the reaction mixture with a weak base.
Claim 6
Dependent Claim
64 words
A process for preparing an imidazoquinazolin-2-one compound represented by the formula: wherein R 1 represents a di-lower alkylamino group having 1 to 6 carbon atoms in its alkyl moiety, a cyclic amino group or a substituted cyclic amino group, which comprises catalytically reducing a compound represented by the formula (IV) : wherein R 1 is as defined above; and X represents a halogen atom.
Claim 7
Dependent Claim
64 words
A process for preparing an imidazoquinazolin-2-one compound represented by the formula: wherein R 1 represents a di-lower alkylamino group having 1 to 6 carbon atoms in its alkyl moiety, a cyclic amino group or a substituted cyclic amino group, which comprises catalytically reducing a compound represented by the formula (IV) : wherein R 1 is as defined above; and X represents a halogen atom.
Claim 8
Dependent Claim
27 words
Pharmaceutical composition containing an imidazo- quinazolin-2-one compound of the general formula (I) as claimed in claims 1 or 2, optionally together with a pharmaceutical carrier and/or diluent.
References Cited (Backward Citations)
No citation records indexed.
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