Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments

Abstract

Abstract Translated from German Die Erfindung betrifft Homologe des Aprotinin, in welchen der Lysinrest im aktiven Zentrum des Inhibitors Aprotininin Pos. 15 ausgetauscht ist gegen einen der Rest der Aminosäuren Glycin, L-Alanin, L-Valin, L-Leucin, L-Isoleucin, L-Methionin, L-Arginin, L-α-Aminobuttersäure, L-Norvalin, L-Norleucin, Dehydroalanin sowie L-Homoserin, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel. The invention relates to homologs of aprotinin in which the lysine residue in the active center of the inhibitor aprotininin item 15 is replaced by one of the residues of the amino acids glycine, L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-arginine, L-α-aminobutyric acid, L-norvaline, L-norleucine, dehydroalanine and L-homoserine, a process for their preparation and their use as medicines.

Inventors

• 👤 Harald Prof. Dr. Tschesche
• 👤 Herbert Dr. Wenzel
• 👤 Rainer Dr. Schmuck
• 👤 Eugen Dr. Schnabel

Bibliographic Details