EP0132534A2
Expired / Lapsed
EP
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Device for the extracorporeal treatment of body fluids
Assignee: Kanegafuchi Chemical Industry Co Ltd
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Filing: 1984-05-25
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Granted: —
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Expires: 2004-05-25
Abstract
Abstract A therapeutic device for removing pathological effectors from body fluids of a patient is disclosed. Said device includes a chamber for receiving the body fluids and positioned within the chamber is a biospecific polymer. Said biospecific polymer interacts with and binds specific pathological effectors carried by the body fluid that is passed through the chamber.
Inventors
- 👤 Mark R. Honard
- 👤 Mark A. Holmes
- 👤 Robert D. Jarrett
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 16:41
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3687; A61M2206/00; A61M2206/10; A61M2206/12
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
82 words
A device for the extracorporeal treatment of diseased body fluid which comprises: (a) means for withdrawing said diseased body fluid from a patient; (b) a chamber having an inlet and outlet port for receiving said body fluid; (c) a biospecific polymer rositioned within said chamber which will interact with and bind specific pathological effectors or specific groups of pathological effectors carried by said body fluid that is passed through said chamber; and (d) means for returning said body fluid to said patient.
Claim 2
Independent Claim
82 words
A device for the extracorporeal treatment of diseased body fluid which comprises: (a) means for withdrawing said diseased body fluid from a patient; (b) a chamber having an inlet and outlet port for receiving said body fluid; (c) a biospecific polymer rositioned within said chamber which will interact with and bind specific pathological effectors or specific groups of pathological effectors carried by said body fluid that is passed through said chamber; and (d) means for returning said body fluid to said patient.
Claim 3
Dependent Claim
32 words
The device as recited in Claim 1 wherein the biospecific polymer comprises: (a) a biocompatible polymer support; and (b) a biological or biologicals immobilized on said biocompatible polymer support via covalent bonding.
Claim 4
Dependent Claim
52 words
The device as recited in Claim 1 wherein the biospecific polymer comprises: (a) a biocompatible polymer support; (b) a spacer covalently bonded to said biocompatible polymer support; and (c) a biological or biologicals immobilized on said spacer such that said biological or biologicals extend away from the surface of said polymer support.
Claim 5
Independent Claim
48 words
The device as recited in Claims 2 or 3 wherein the biospecific polymer is of any suitable structural configuration with the caveat that sufficient surface area of the biospecific polymer is exposed to the body fluid to be treated to efficiently remove the desired amount of pathological effector.
Claim 6
Independent Claim
17 words
The device as recited in Claims 2 or 3 wherein the biocompatible polymer support is a hydrogel.
Claim 7
Independent Claim
30 words
The device as recited in Claims 2 or 3 wherein the biocompatible polymer support is selected from the group consisting of polymerized glycidyl acrylate, polymerized glycidyl methacrylate and mixtures thereof.
Claim 8
Independent Claim
21 words
The device as recited in Claims 2 or 3 wherein the biocompatible polymer support is the slightly cross-linked homopolymer hydroxyethyl methacrylate.
Claim 9
Independent Claim
57 words
The device as recited in Claims 2 or 3 wherein the biocompatible polymer support is selected from the group consisting of copolymerized N-vinyl pyrrolidone and glycidyl methacrylate said copolymer further containing a monomer selected from the group consisting of hydroxyalkylacrylates, hydroxyalkylmethacrylates, acrylamides, substituted acrylamides, vinyl glycidyl ethers, alkyl- glycidyl ethers, N-vinyl amides, vinyl acetate and mixtures thereof.
Claim 10
Independent Claim
51 words
The device as recited in Claims 2 or 3 wherein the biologicals are selected from the group consisting of acetylcholine receptor proteins, histocompatibility antigens, ribonucleic acids, basement membrane proteins, immunoglobulin classes and subclasses, myeloma protein receptors, complement components, myelin proteins, hormones and their receptor components and vitamins and their receptor components.
Claim 11
Independent Claim
28 words
The device as recited in Claims 2 or 3 wherein the biological is insulin used to remove anti-insulin antibody which is associated with the autoimmune disease insulin resistance.
Claim 12
Independent Claim
35 words
The device as recited in Claims 2 or 3 wherein the biological is purified gamma globulin to remove immune components which are associated with connective tissue and proliferative diseases such as rheumatoid arthritis and carcinoma.
Claim 13
Independent Claim
18 words
The device as recited in Claims 2 or 3 wherein the biocompatible polymer support is modified cellulose acetate.
Claim 14
Independent Claim
25 words
The device as recited in Claims 2 or 3 further characterized in that said biocompatible polymer support is fixed to a mechanically stable support member.
Claim 15
Dependent Claim
35 words
The device as recited in Claim 13 wherein the mechanically stable support member is selected from the group consisting of polyester fiber, reticulated polymeric foams, microporous polypropylene, cotton cloth, polystyrene; polycarbonate, polyphenylene oxide, and polysiloxane.
Claim 16
Independent Claim
107 words
A device for the extracorporeal treatment of a body fluid which comprises: (a) means for withdrawing said body fluid from a patient; (b) a chamber having an inlet and outlet port for receiving said body fluid; (c) a plurality of mechanically stable support members positioned adjacently within said chamber so that the body fluid flows therebetween; (d) a biospecific polymer fixed on said mechanically stable support members wherein said biospecific polymer interacts with and binds a specific pathological effector or a group of pathological effectors carried by said body fluid that is passed through said chamber; and (e) means for returning said body fluid to said patient.
Claim 17
Independent Claim
107 words
A device for the extracorporeal treatment of a body fluid which comprises: (a) means for withdrawing said body fluid from a patient; (b) a chamber having an inlet and outlet port for receiving said body fluid; (c) a plurality of mechanically stable support members positioned adjacently within said chamber so that the body fluid flows therebetween; (d) a biospecific polymer fixed on said mechanically stable support members wherein said biospecific polymer interacts with and binds a specific pathological effector or a group of pathological effectors carried by said body fluid that is passed through said chamber; and (e) means for returning said body fluid to said patient.
Claim 18
Dependent Claim
52 words
The device as recited in Claim 15 wherein the biospecific polymer comprises: (a) a biocompatible polymer support; (b) a spacer covalently bonded to said biocompatible polymer support; and (c) a biological or biologicals immobilized on said spacer such that said biological or biologicals extend away from the surface of said polymer support.
Claim 19
Dependent Claim
23 words
The device as recited in Claim 16 wherein the biocompatible polymer support comprises a terpolymer of glycidyl methacrylate, N-vinyl pyrrolidone and hydroxyethyl methacrylate.
Claim 20
Dependent Claim
70 words
A therapeutic method for the treatment of diseases which comprises: (a) withdrawing a body fluid from a patient; (b) passing said body fluid through a chamber in contact with a biospecific polymer positioned within said chamber, wherein a specific pathological effector or a specific group of pathological effectors carried by said body fluid interact with and bind to said biospecific polymer; and (c) returning said body fluid to said patient.
Claim 21
Dependent Claim
70 words
A therapeutic method for the treatment of diseases which comprises: (a) withdrawing a body fluid from a patient; (b) passing said body fluid through a chamber in contact with a biospecific polymer positioned within said chamber, wherein a specific pathological effector or a specific group of pathological effectors carried by said body fluid interact with and bind to said biospecific polymer; and (c) returning said body fluid to said patient.
Claim 22
Dependent Claim
17 words
The therapeutic method as recited in Claim 18 wherein the withdrawing and returning steps are continuously performed.
Claim 23
Dependent Claim
30 words
The therapeutic method as recited in Claim 18 wherein the body fluid to be treated is selected from the group consisting of blood, whole blood, blood plasma, and cerebrospinal fluid.
References Cited (Backward Citations)
No citation records indexed.
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