EP0131418A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Proteins, pharmaceutical compositons, genes, vectors, host organisms and processes for their production
Assignee: Celltech R&D Ltd
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Filing: 1984-06-29
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Granted: —
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Expires: 2004-06-29
Abstract
Abstract @ A rat or human lingual lipase protein for use in the treatment of lipase deficiency. A process is described for producing lingual lipase using recombinant DNA technoloy to produce a host organism (for example E.coli) capable of producing a precursor of the lingual lipase which may be cleaved to yield the lingual lipase. The host organism is transformed with a vector including a gene coding for the precursor of lingual lipase. The precursor protein is for example prelingual lipase protein, or a fusion protein comprising lingual lipase and a heterologous protein. A pharmaceutical composition in unit dosage or liquid form is described.
Inventors
- 👤 Robert Williamson
- 👤 Norman Henry Carey
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 12:59
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/16; C12N9/18; C12N9/20
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
12 words
A lingual lipase protein for use in the treatment of lipase deficiency.
Claim 2
Dependent Claim
12 words
A lingual lipase protein for use in the treatment of lipase deficiency.
Claim 3
Dependent Claim
19 words
A lingual lipase protein according to claim 1 wherein the lingual lipase protein is a human lingual lipase protein.
Claim 4
Dependent Claim
19 words
A lingual lipase protein according to claim 1 wherein the lingual lipase protein is a rat lingual lipase protein.
Claim 5
Dependent Claim
30 words
A process for the production of a methionine-lingual lipase protein comprising producing the protein in a host organism transformed with a vector including'a gene coding for the methionine-lingual lipase protein.
Claim 6
Dependent Claim
30 words
A process for the production of a methionine-lingual lipase protein comprising producing the protein in a host organism transformed with a vector including'a gene coding for the methionine-lingual lipase protein.
Claim 7
Dependent Claim
44 words
A process for the production of a lingual lipase protein comprising producing a lingual lipase precursor protein in a host organism transformed with a vector including a gene coding for the precursor protein and cleaving the precursor protein, to produce the lingual lipase protein.
Claim 8
Dependent Claim
44 words
A process for the production of a lingual lipase protein comprising producing a lingual lipase precursor protein in a host organism transformed with a vector including a gene coding for the precursor protein and cleaving the precursor protein, to produce the lingual lipase protein.
Claim 9
Dependent Claim
38 words
A process according to claim 5 wherein the lingual lipase precursor protein is a prelingual lipase protein and the host organism is a host organism capable of cleaving the prelingual lipase protein to produce the lingual lipase protein.
Claim 10
Dependent Claim
17 words
A process according to claim 6 wherein the host organism is a mammalian cell in tissue culture.
Claim 11
Dependent Claim
20 words
A process according to claim 5 wherein the lingual lipase'precursor protein comprises a heterologous protein and a lingual lipase protein.
Claim 12
Dependent Claim
4 words
A prelingual lipase protein.
Claim 13
Dependent Claim
4 words
A prelingual lipase protein.
Claim 14
Dependent Claim
4 words
A methionine-lingual lipase protein.
Claim 15
Dependent Claim
4 words
A methionine-lingual lipase protein.
Claim 16
Dependent Claim
12 words
A fusion protein comprising a lingual lipase protein and a heterologous protein.
Claim 17
Dependent Claim
12 words
A fusion protein comprising a lingual lipase protein and a heterologous protein.
Claim 18
Dependent Claim
18 words
A gene coding for a protein comprising at least the amino acid sequence of a lingual lipase protein.
Claim 19
Dependent Claim
18 words
A gene coding for a protein comprising at least the amino acid sequence of a lingual lipase protein.
Claim 20
Dependent Claim
19 words
A gene according to claim 12 coding for a protein according to any one of claims 1,2,3,9,10 and 11.
Claim 21
Dependent Claim
11 words
A vector including a gene according: to claim 12 or 13.
Claim 22
Dependent Claim
11 words
A host organism transformed with a vector according to claim 14.
Claim 23
Dependent Claim
13 words
An antibody having specificity for an antigenic determinant of a lingual lipase protein.
Claim 24
Dependent Claim
13 words
An antibody having specificity for an antigenic determinant of a lingual lipase protein.
Claim 25
Dependent Claim
13 words
A pharmaceutical composition comprising a lingual lipase protein and a pharmaceutically acceptable excipient.
Claim 26
Dependent Claim
13 words
A pharmaceutical composition comprising a lingual lipase protein and a pharmaceutically acceptable excipient.
Claim 27
Dependent Claim
32 words
A pharmaceutical composition according to claim 17 wherein the lingual lipase protein is a lingual lipase protein according to claim 2 or 3 produced by the process of claim 4 or 5.
Claim 28
Dependent Claim
13 words
A pharmaceutical composition according to claim 17 or 18 in unit dosage form.
Claim 29
Dependent Claim
13 words
A pharmaceutical composition according to claim 17 or 18 in a liquid form.
References Cited (Backward Citations)
No citation records indexed.
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