EP0128706A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Body implants of extracellular matrix and means and methods of making and using such implants
Assignee: University Patents Inc
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Filing: 1984-05-31
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Granted: —
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Expires: 2004-05-31
Abstract
Abstract A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.
Inventors
- 👤 Klaus Brendel
- 👤 Raymond C. Duhamel
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3633; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/10; A61F2/28; A61L27/3683; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917; Y10S623/919; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
36 words
A sterile body implant comprising a body derived structure having as its major component collagens and elastin in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
Claim 2
Dependent Claim
36 words
A sterile body implant comprising a body derived structure having as its major component collagens and elastin in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
Claim 3
Dependent Claim
33 words
A body implant in accordance with claim I wherein said implant is sized and dimensioned to be compatible with the histoarchitecture of a body portion to which the implant is to be attached.
Claim 4
Dependent Claim
35 words
A sterile body implant in accordance with claim 1 wherein said implant is treated shortly after said body structure is removed from the body and prior to substantial chemical cross-linking or change thereof with detergents.
Claim 5
Dependent Claim
22 words
A sterile body implant in accordance with claim 3 ana further comprising said detergents comprising a aenaturing detergent and a non-denaturing detergent.
Claim 6
Independent Claim
64 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with at least one detergent while maintaining said tissue in a suitable size and form for implantation in the body.
Claim 7
Independent Claim
64 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with at least one detergent while maintaining said tissue in a suitable size and form for implantation in the body.
Claim 8
Dependent Claim
50 words
A method in accordance with the method of claim 5 wherein said tissue is treated with a first detergent which is non-aenaturing to remove cytoplasmic cell membranes but not nuclear membranes while preventing degradation of extracellular matrix and extracting said tissue with a second detergent which is a denaturing detergent.
Claim 9
Dependent Claim
30 words
A method in accordance with the method of claim 5 wherein said second detergent is a denaturing detergent and is applied in a second step apart from said first detergent.
Claim 10
Dependent Claim
36 words
A method in accordance with the method of claim 5 wherein said second detergent is a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant.
Claim 11
Dependent Claim
43 words
A method in accordance with the method of claim 8 wherein said anionic detergent is a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane or sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
Claim 12
Dependent Claim
16 words
A method in accordance with the method of claim 9 wherein said detergent is sodium dodecylsulfate.
Claim 13
Dependent Claim
23 words
A method in accordance with the method of claim 8 and further comprising cross-linking said body tissue prior to implantation in the body.
Claim 14
Dependent Claim
20 words
A method in accordance with the method of claim 8 wherein said first detergent is admixed with a protease inhibitor.
Claim 15
Dependent Claim
19 words
A method in accordance with the method of claim 8 wherein said first detergent is admixed with a DNase.
Claim 16
Dependent Claim
18 words
A methoa in accordance with the method of claim 8 wnerein saia boay implant is a vascular graft.
Claim 17
Dependent Claim
18 words
A method in accordance with the method of claim 8 wherein said body implant is a bone implant.
Claim 18
Dependent Claim
18 words
A method in accordance with the method of claim 8 wherein said body implant is a tooth implant.
Claim 19
Dependent Claim
18 words
A method in accordance with the method of claim 8 wherein said body implant is a skin implant.
Claim 20
Independent Claim
68 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major component collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body.
Claim 21
Independent Claim
68 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major component collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body.
Claim 22
Dependent Claim
18 words
A method in accordance with the method of claim 18 wherein said whole structure is a vascular graft.
Claim 23
Dependent Claim
17 words
A method in accordance with the method of claim 18 wherein said whole structure is a tooth.
Claim 24
Dependent Claim
20 words
A method in accordance with the method of claim 18 wherein said whole structure is an area of the skin.
Claim 25
Dependent Claim
47 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body.
Claim 26
Dependent Claim
47 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body.
Claim 27
Dependent Claim
23 words
The improvement of claim 22 and further comprising said body tissue being treated with a first non-denaturing detergent and a second denaturing detergent.
Claim 28
Dependent Claim
28 words
A method in accordance with the method of claim 23 wherein said detergents are used in sequence ana a protease inhibitor is used along with said first detergent.
Claim 29
Dependent Claim
19 words
A methoa in accordance with the method of claim 24 wherein a DNase is admixed with saia first detergent.
Claim 30
Dependent Claim
49 words
A method in accordance with the method of claim 23 wherein said second detergent is a strongly anionic detergent which is a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane or sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
Claim 31
Independent Claim
53 words
A method of using a body implant which has been treated with a detergent to form an extracellular matrix, said method comprising implanting said extracellular matrix in a living body to repair or replace a body portion wherein said matrix is designed to be compatible with the body, nonantigenic and capable of recellularization.
Claim 32
Independent Claim
53 words
A method of using a body implant which has been treated with a detergent to form an extracellular matrix, said method comprising implanting said extracellular matrix in a living body to repair or replace a body portion wherein said matrix is designed to be compatible with the body, nonantigenic and capable of recellularization.
Claim 33
Dependent Claim
34 words
A sterile body implant comprising a body derived structure having as its major component collagens in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
Claim 34
Dependent Claim
34 words
A sterile body implant comprising a body derived structure having as its major component collagens in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
References Cited (Backward Citations)
No citation records indexed.
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