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EP0121067A1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Process for the preparation of oligosaccharide fractions having pharmacological properties by chemical degradation of heparin

Assignee: Opocrin SpA
•
Filing: 1984-02-18
•
Granted: —
•
Expires: 2004-02-18
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Abstract

Abstract Process for the preparation of oligosaccharides and oligosaccharide fractions by degradation of heparin, which comprises submitting to incubation an aqueous solution of heparin containing from 5 to 30 g of heparin/liter in the presence of 4-50 m.moles/i of cupric acetate and 50-300 m.moles/1 of hydrogen peroxide, at a temperature of 40-50°C, for 20-24 hours and keeping the pH at a value of7.8 by means of sodium acetate. The obtained products show a high inhibiting property of the Xa factor, a high antithrombotic activity and a very modest anticoagulant activity; therefore they are very interesting for a possible utilization as drugs in the antithrombotic treatment, practically free from any risk of haemorrhages.

Inventors

  • 👤 Pietro Bianchini

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-30 23:06
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08B37/0078; A; A61; A61P; A61P7/00; A61P7/02

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 98 words
Process for the preparation of oligosaccharide fractions provided with pharmacological properties, by means of heparin degradation, characterized by the fact that an aqueous heparin solution containing from 5 to 20 g of heparin per 1. is submitted to incubation in the presence of from 4 to 50 m.moles/l of ascorbic acid, of from 0.4 to 2.5 m.moles/l of cupric acetate, and of from 50 to 300 m.moles/l of hydrogen peroxide at a temperature comprised between 40 and 50°C for 20-24 hours and maintaining the pH at a value comprised between 7.5 and 8 by means of cupric acetate.
Claim 2
Dependent Claim 98 words
Process for the preparation of oligosaccharide fractions provided with pharmacological properties, by means of heparin degradation, characterized by the fact that an aqueous heparin solution containing from 5 to 20 g of heparin per 1. is submitted to incubation in the presence of from 4 to 50 m.moles/l of ascorbic acid, of from 0.4 to 2.5 m.moles/l of cupric acetate, and of from 50 to 300 m.moles/l of hydrogen peroxide at a temperature comprised between 40 and 50°C for 20-24 hours and maintaining the pH at a value comprised between 7.5 and 8 by means of cupric acetate.
Claim 3
Dependent Claim 21 words
Process according to claim 1 characterized by the fact that the process is carried out at a pH value of 7.8.
Claim 4
Dependent Claim 64 words
Process according to claim 1, characterized by the fact that the aqueous heparin solution con tains 10 g/1 of heparin, 20 m.moles/l of ascorbic acid, 2.25 m.moles of cupric acetate, and 180 m.moles/l of hydrogen peroxide and by the fact that the process is carried out at a temperature of 50°C for 24 hours at a value of 7.8 by means of sodium acetate.
Claim 5
Dependent Claim 15 words
Oligosaccharides fractions of heparin obtained by means of the process defined by the preceding claims.

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