EP0110409A2
Expired / Lapsed
EP
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Adsorbent and process for preparing the same
Assignee: Kanegafuchi Chemical Industry Co Ltd
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Filing: 1983-12-01
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Granted: —
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Expires: 2003-12-01
Abstract
Abstract Adsorbent for removing a harmful substance to be removed from body fluid such as blood or plasma composed of a porous hard gel on which a ligand having an affinity for the harmful substance is immobilized. The adsorbent is suitable for selective removal of harmful substances such as VLDL, LDL, harmful proteins, viruses and harmful cells, in extracorporeal circulation treatment.
Inventors
- 👤 Nobutaka Tani
- 👤 Tsuneo Hayashi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 01:29
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3272; B01J20/3274; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0456; A61M2202/046
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
34 words
An adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment comprising a water-insoluble porous hard gel on which a ligand having an affinity for the substance is immobilized.
Claim 2
Dependent Claim
34 words
An adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment comprising a water-insoluble porous hard gel on which a ligand having an affinity for the substance is immobilized.
Claim 3
Dependent Claim
18 words
The adsorbent of Claim 1, wherein said water-insoluble porous hard gel is a water-insoluble porous polymer hard gel.
Claim 4
Dependent Claim
17 words
The adsorbent of Claim 2, wherein said water-insoluble porous polymer hard gel is a porous cellulose gel.
Claim 5
Dependent Claim
17 words
The adsorbent of Claim 1, wherein said water-insoluble porous hard gel is a porous inorganic hard gel.
Claim 6
Dependent Claim
28 words
The adsorbent of Claim 4, wherein said porous inorganic hard gel is a member selected from the group consisting of porous glass, porous silica gel and porous alumina.
Claim 7
Dependent Claim
12 words
The adsorbent of Claim 1, wherein said ligand is a polyanion compound.
Claim 8
Dependent Claim
13 words
The adsorbent of Claim 6, wherein said polyanion compound is a sulfated polysaccharide.
Claim 9
Dependent Claim
26 words
The adsorbent of Claim 7, wherein said sulfated polysaccharide is a member selected from the group consisting of heparin, dextran sulfate, chondroitin sulfate, and their salts.
Claim 10
Dependent Claim
14 words
The adsorbent of Claim 1, wherein said substance to be removed is a lipoprotein.
Claim 11
Dependent Claim
24 words
The adsorbent of Claim 9, wherein an exclusion limit of the water-insoluble porous hard gel is from 1 0 6 to 10 9 .
Claim 12
Dependent Claim
16 words
The adsorbent of Claim 10, wherein said exclusion limit is 10 6 to 10 8 .
Claim 13
Dependent Claim
15 words
The adsorbent of Claim 9, wherein said lipoprotein is VLDL, LDL or an admixture thereof.
Claim 14
Dependent Claim
34 words
The adsorbent of Claim 1 comprising a water-insoluble porous hard gel having an exclusion limit of 10 6 to 10 8 on which a polyanion compound having an affinity for a lipoprotein is immobilized.
Claim 15
Dependent Claim
23 words
The adsorbent of Claim 6, wherein said polyanion compound is immobilized in an amount of 0.02 mg to 100 mg/ml of bed volume.
Claim 16
Dependent Claim
43 words
The adsorbent of Claim 8, said dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt has an intrinsic viscosity of not more than 0.12 dl/g and a sulfur content of not less than 15 % by weight.
Claim 17
Dependent Claim
35 words
The adsorbent of Claim 8, said dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt is immobilized in an amount of not less than 0.2 mg/ml of bed volume.
Claim 18
Dependent Claim
34 words
The adsorbent of Claim 1, wherein a dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt is immobilizd on a water-insoluble porous cellulose gel by a covalent linkage.
Claim 19
Dependent Claim
37 words
A process of preparing an adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment which comprises immobilizing a ligand having an affinity for the substance on a water-insoluble porous hard gel.
Claim 20
Dependent Claim
37 words
A process of preparing an adsorbent for removing a substance to be removed from body fluid in extracorporeal circulation treatment which comprises immobilizing a ligand having an affinity for the substance on a water-insoluble porous hard gel.
Claim 21
Dependent Claim
37 words
The process of Claim 18, wherein said water-insoluble porous hard gel is reacted with epichlorohydrin or a polyoxirane compound to introduce epoxy groups into the gel and then the resulting epoxy-activated gel is reacted with a ligand.
Claim 22
Dependent Claim
18 words
The process of Claim 19, wherein said water-insoluble porous hard gel is a water-insoluble porous polymer hard gel.
Claim 23
Dependent Claim
17 words
The process of Claim 20, wherein said water-insoluble porous polymer hard gel is a porous cellulose gel.
Claim 24
Dependent Claim
73 words
The process of Claim 19, wherein said ligand is dextran sulfate, a salt thereof or a mixture of the dextran sulfate and the salt, said dextran sulfate, the salt thereof or the mixture of the dextran sulfate and the salt being reacted with said epoxy-activated gel in a concentration of not less than 3 % based on the weight of the whole reaction system excluding the dry weight of the porous hard gel.
Claim 25
Dependent Claim
15 words
The process of Claim 22, wherein said porous hard gel is a porous cellulose gel.
References Cited (Backward Citations)
No citation records indexed.
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