EP0108933A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Poly(glycolic acid)/poly(oxyethylene)triblock copolymers and method of manufacturing the same
Assignee: Wyeth Holdings LLC
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Filing: 1983-10-12
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Granted: —
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Expires: 2003-10-12
Abstract
Abstract Poly(glycolic acid)poly(oxyethylene) ABA triblock copolymers having the following formula: wherein x ist about 37.5 to 47.5 and y is about 5 to 25, weight percent. The copolymers are useful for manufacturing fibers possessing a sufficiently low modulus of elasticity to permit their use as absorbable sutures having the requisite flexibility for use in monofilament form. A process of preparation involves purifying the hydroxyl-ended poly(oxyalkylene) and allowing it to react with glycolide to produce an ABA triblock copolymer of extrusion grade in which A represents a polyglycolic acid block and B represents a poly(oxyalkylene) block.
Inventors
- 👤 Donald James Casey
- 👤 Mark Sinclair Roby
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 14:07
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/12; A61L27/00; A61L27/14; A61L27/18; A61L31/00; A61L31/04; A61L31/06
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
35 words
A triblock copolymer useful for the manufacture of bioabsorbable surgical articles comprising the formula; wherein R represents an alkylene, x is about 37.5 to 47.5 and y is about 5 to 25 , weight percent.
Claim 2
Dependent Claim
35 words
A triblock copolymer useful for the manufacture of bioabsorbable surgical articles comprising the formula; wherein R represents an alkylene, x is about 37.5 to 47.5 and y is about 5 to 25 , weight percent.
Claim 3
Dependent Claim
60 words
A triblock copolymer for use in manufacturing absorbable surgical articles comprising the formula: wherein R represents an alkylene, x is about 37.5 to 47 .5 and y is about 5 to 25, mole percent, and having, as an extruded fiber, a straight pull tensile strength in excess of 40,000 psi and a modulus less than 2.5 X 10 6 psi.
Claim 4
Dependent Claim
60 words
A triblock copolymer for use in manufacturing absorbable surgical articles comprising the formula: wherein R represents an alkylene, x is about 37.5 to 47 .5 and y is about 5 to 25, mole percent, and having, as an extruded fiber, a straight pull tensile strength in excess of 40,000 psi and a modulus less than 2.5 X 10 6 psi.
Claim 5
Dependent Claim
26 words
A triblock copolymer as claimed in claim 2 having an in vivo absorbability, as measured by subcutaneous implantation in rabbits, of 100 percent after 60 days.
Claim 6
Dependent Claim
16 words
A triblock copolymer as claimed in claim 1 or 2 or 3 wherein R is poly(oxyethylene).
Claim 7
Dependent Claim
14 words
A suture or ligature manufactured from a triblock copolymer as claimed in claim 4.
Claim 8
Independent Claim
88 words
A method for preparing extrusion weight triblock copolymers having the formula: wherein R represents an alkylene, x is about 37.5 to 47.5 and y is about 5 to 25, mole percent, comprising reacting purified hydroxyl-ended poly(alkylene oxide) with glycolide by charging the respective constituents to a stirred reactor in the presence of stannous chloride dihydrate, heating at a temperature of 220-228°C for a period of time sufficient to achieve the desired reaction, followed by cooling and recovering a solidified copolymer having an intrinsic viscosity of at least 0.60.
Claim 9
Independent Claim
88 words
A method for preparing extrusion weight triblock copolymers having the formula: wherein R represents an alkylene, x is about 37.5 to 47.5 and y is about 5 to 25, mole percent, comprising reacting purified hydroxyl-ended poly(alkylene oxide) with glycolide by charging the respective constituents to a stirred reactor in the presence of stannous chloride dihydrate, heating at a temperature of 220-228°C for a period of time sufficient to achieve the desired reaction, followed by cooling and recovering a solidified copolymer having an intrinsic viscosity of at least 0.60.
Claim 10
Dependent Claim
63 words
A method as claimed in claim 7 wherein the purified hydroxyl-ended poly(alkylene oxide) is obtained by passing an aqueous solution of the poly(alkylene oxide) through an ion exchange resin bed, extracting the resulting effluent with a solvent, removing the solvent fraction, adding acetone to the remaining fraction and allowing it to cool to provide solidified poly(alkylene oxide) and filtering to recover the same.
Claim 11
Dependent Claim
24 words
A method for manufacturing a surgical article comprising extruding the triblock copolymer produced by the method as claimed in claim 6 or 7. \
Claim 12
Dependent Claim
35 words
A surgical article as claimed in claim 6 or 7 selected from the group consisting of a suture, ligature, needle and suture combination, surgical clip, surgical staple, surgical prosthesis, textile structure, coupling, tube, and support.
Claim 13
Dependent Claim
57 words
A composition for the controlled continuous administration of a predetermined dosage of a pharmaceutical drug to a living animal comprising a material selected from the group consisting of a self-supporting film, a hollow tube, a plurality of beads, and a gel, said material manufactured from a copolymer made according to a method of claim 6 or 7.
References Cited (Backward Citations)
DE2242298A1
Cited
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