EP0108588A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Plasma-free medium for platelet storage and its production
Assignee: ROCK, GAIL ANN
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Filing: 1983-10-31
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Granted: —
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Expires: 2003-10-31
Abstract
Abstract A blood platelet concentrate comprises blood platelets in a balanced salt solution containing an anticoagulant and that is substantially free of plasma. Generally the solution contains one or more additives to enhance platelet storage. A blood platelet concentrate may be made by centrifuging blood plasma to obtain a platelet pellet, removing the supernatant plasma and resuspending the pellet in a balanced salt solution containing anticoagulant.
Inventors
- 👤 Gail Ann Rock
- 👤 George Allen Adams
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 16:19
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/19
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
29 words
A platelet concentrate comprising blood platelets in a salt solution characterised in that the solution is a balanced salt solution containing anticoagulant and that is substantially free of plasma.
Claim 2
Dependent Claim
29 words
A platelet concentrate comprising blood platelets in a salt solution characterised in that the solution is a balanced salt solution containing anticoagulant and that is substantially free of plasma.
Claim 3
Dependent Claim
22 words
A concentrate according to elaim 1 in which the solution contains one or more additives to enhance the stability of the platelets.
Claim 4
Dependent Claim
22 words
A concentrate according to elaim 1 in which the solution contains one or more additives to enhance the stability of the platelets.
Claim 5
Dependent Claim
52 words
A concentrate according to claim 1, in which the solution contains one or more additives selected from nutrients to improve the storage life of platelets, reversible inhibitors for platelet activation, substances to raise cyclic adenosine monophosphate levels and have reversible affects on platelets and buffering agents which can be infused into patients.
Claim 6
Dependent Claim
81 words
A concentrate according to claim 3, in which the solution contains one or more additives selected from (a) nutrients selected from fructose and other sugars, adenine and acetyl CoA, (b) reversible inhibitors for platelet activation selected from indomethacin, quinacrine or vitamin E, (c) substances to raise cyclic adenosine monophosphate levels selected from prostaglandins E 1 , D 2 and I 2 , and (d) buffering agents selected from phosphate and amino acids, preferably selected from histidine, cysteine, tyrosine, lysine and arginine.
Claim 7
Dependent Claim
44 words
A concentrate according to any preceding claim, in which the balanced salt solution is selected from Spinner salt solution, Tyrode's solution, Seligmann balanced salt solution, Earle's balanced salt solutions, Dulbecco's phosphate buffered saline, Hank's balanced salt solutions, Gey's balanced salt solutions and Puck's saline.
Claim 8
Dependent Claim
25 words
A concentrate according to any preceding claim, in which the balanced salt solution is a Tyrode's solution containing a phosphate buffer or a histidine buffer.
Claim 9
Dependent Claim
14 words
A concentrate according to any preceding claim, in which the plasma is human plasma.
Claim 10
Dependent Claim
17 words
A concentrate according to any preceding claim, in which the balanced salt solution is an isotonic solution.
Claim 11
Dependent Claim
23 words
A concentrate according to any preceding claim, in which the anticoagulant in the balanced salt solution is selected from acid-citrate-dextrose, citrate-phosphate--dextrose and heparin.
Claim 12
Independent Claim
44 words
A method for making a blood plasma concentrate comprising centrifuging plasma to obtain a platelet pellet and resuspending the plasma characterised in that supernatant plasma is removed from the platelet pellet and the pellet is then resuspended in a balanced salt solution containing anticoagulant.
Claim 13
Independent Claim
44 words
A method for making a blood plasma concentrate comprising centrifuging plasma to obtain a platelet pellet and resuspending the plasma characterised in that supernatant plasma is removed from the platelet pellet and the pellet is then resuspended in a balanced salt solution containing anticoagulant.
Claim 14
Dependent Claim
25 words
A method according to claim 10, characterised in that the balanced salt solution contains one or more additives to enhance the stability of the platelets.
Claim 15
Dependent Claim
24 words
A method according to claim 10, in which the balanced salt solution contains one or more additives as defined in claims 3 or 4.
Claim 16
Independent Claim
27 words
A method according to any of claims 10 to 12, in which the balanced salt solution is as defined in any of claims 5, 6 or 8.
Claim 17
Independent Claim
26 words
A method according to any of claims 10 to 13, in which the anticoagulant in the balanced salt solution is selected from acid-citrate-dextrose, citrate-phosphate--dextrose and heparin.
Claim 18
Independent Claim
26 words
A method according to any of claims 10 to 14, in which the plasma is human plasma derived from freshly collected whole blood or by apheresis.
Claim 19
Independent Claim
37 words
A method according to any of claims 10 to 16, in which, after removing the supernatant plasma, the pellets are washed to remove plasma from them prior to final suspension in the balanced salt solution containing anticoagulant.
References Cited (Backward Citations)
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