1-N-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Claim 1

A compound of the formula: wherein: R is hydrogen; alkyl of from 1 to 12 carbon atoms which include branched, cyclic and unsaturated alkyl groups; substituted loweralkyl wherein the substituent can be halo, hydroxy, carboxy, loweralkylthio, loweralkoxy, loweralkoxycarbonyl, loweraralkoxycarbonyl, amino, loweralkylamino, lowerdialkylamino, or acylamino substituted loweralkyl having the formula R 1 (CH 2 ) n -Q-(CH 2 ) m wherein n is A 0 -2, m is 1-3, R 1 is aryl or heteroaryl A optionally substituted by amino, lowerdialkylamino, loweralkylamino, hydroxy, hydroxyloweralkyl, aminoloweralkyl, trihaloloweralkyl, cyano, nitro, sulfonamido, aroyl, loweralkyl, halo, dihalo, and loweralkoxy, and Q is O, S, N- , , CO, CH=CH wherein is hydrogen, loweralkyl, aryl, aralkyl, loweralkanoyl, or aroyl, and R 1 is hydrogen, or loweralkyl; C aryl; substituted aryl wherein the substituent is loweralkyl, aminoloweralkyl, loweralkoxy, aryloxy, aroyl, hydroxy, halo, or dihalo; aralkyl or heteroaralkyl which include branched loweralkyi groups; substituted aralkyl or substituted heteroaralkyl which include branched loweralkyl groups wherein the loweralkyl groups can be substituted by amino, acylamino, or hydroxyl and the aryl and heteroaryl groups can be substituted by halo, dihalo, loweralkyl, hydroxy, loweralkoxy, aryloxy, aroyl, arylthio, amino, aminoloweralkyl, loweralkanoylamino, aroylamino, lowerdialkylamino, loweralkylamino, hydroxyloweralkyl, trihaloloweralkyl, nitro, cyano, or sulfonamido; R 2 and R 4 are independently hydroxy; loweralkoxy; loweralkenyloxy; arloweralkoxy; acylloweralkoxy; amino; loweralkylamino; diloweralkylamino; carboxymethylamino; carboxamidomethylamino; or aryloxy, or mono-or disubstituted aryloxy wherein the substituents are chloro; m is 1-4; R 3 is where n is 2-5; provided that where n=3 or 4, the carbon chain may be unsaturated between carbons 2-3 for n=3, and between carbons 2-3 or 3-4 or both for n=4; the R a 's are independently hydrogen; hydroxy; amino; mono- or diloweralkylamino; loweralkyl; phenyl; phenoxy; phenylloweralkyl; hydroxyphenylloweralkyl; aminoloweralkyl; hydroxyloweralkyl; mercaptoloweralkyl; loweralkylthioloweralkyl; imidazolylloweralkyl; indolylloweralkyl; carboxyl; carboxamide; loweralkoxycarbonyl; carboxyloweralkyl; carboxamidoloweralkyl; or loweralkoxycarbonylloweralkyl; and the R b 's are independently hydrogen or loweralkyl; R 5 is hydrogen; halo: hydroxy; loweralkyl; loweralkoxy; amino; or mono- or diloweralkylamino; and a pharmaceutically acceptable salt thereof.