EP0106281A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Analgesia-effecting 5-hydroxytryptophan derivatives
Assignee: Yeda Research and Development Co Ltd
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Filing: 1983-10-06
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Granted: —
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Expires: 2003-10-06
Abstract
Abstract Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: and wherein R is selected from the group consisting of C 2 -C 16 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 16 alkenyl. C 2 -C 16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms; R' and R" are each H or methyl; R 2 and R 2a are each H or R, as defined above; R 3 and R 3a are each H or alkyl containing from 1 to 4 carbons; R 4 and R 4a are each H or alkyl containing from 1 to 4 carbons; and their non-toxic, pharmacologically acceptable acid addition salts.
Inventors
- 👤 Hadassah Tamir
- 👤 Stephen E. Karpiak
- 👤 Meir Wilchek
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 20:41
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06156; A; A61; A61P; A61P25/00; A61P25/04; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
119 words
A compound selected from the group consisting of 5-hydroxytryptophan derivatives of the formulae: and wherein R is selected from the group consisting of C 2 -C 16 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 16 alkenyl, C 2 -C 16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms; R 1 and R la are each H or methyl; R 2 and R 2a are each H or R, as defined above; R 3 and R 3a are each H or alkyl contaning from 1 to 4 carbons; Rand R 4a are each H or alkyl containing from 1 to 4 carbons; and their non-toxic, pharmacologically acceptable acid addition salts.
Claim 2
Dependent Claim
119 words
A compound selected from the group consisting of 5-hydroxytryptophan derivatives of the formulae: and wherein R is selected from the group consisting of C 2 -C 16 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 16 alkenyl, C 2 -C 16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms; R 1 and R la are each H or methyl; R 2 and R 2a are each H or R, as defined above; R 3 and R 3a are each H or alkyl contaning from 1 to 4 carbons; Rand R 4a are each H or alkyl containing from 1 to 4 carbons; and their non-toxic, pharmacologically acceptable acid addition salts.
Claim 3
Dependent Claim
39 words
2 . Compounds of claim 1 having formula I wherein R is alkyl of 3 to 6 carbons, R 1 is H, R 2 and R 2a are each H, R 3 is H and R 4 is H.
Claim 4
Dependent Claim
9 words
A compound of claim 2 wherein R is n-pentyl.
Claim 5
Dependent Claim
9 words
A compound of claim 2 wherein R is n-propyl.
Claim 6
Dependent Claim
9 words
A compound of claim 2 wherein R is n-butyl.
Claim 7
Dependent Claim
9 words
A compound of claim 2 wherein R is n-hexyl.
Claim 8
Dependent Claim
50 words
Compounds of claim 1 having formula II wherein R is akyl of 3 to 6 carbons, R 1 and R 1a are each H, R 2 and R 2a are each H , R 3 and R 3a are each H, and R 4 and R 4a are each H.
Claim 9
Dependent Claim
9 words
A compound of claim 7 wherein R is n-pentyl.
Claim 10
Dependent Claim
9 words
A compound of claim 7 wherein R is n-propyl.
Claim 11
Dependent Claim
9 words
A compound of claim 7 wherein R is n-butyl.
Claim 12
Dependent Claim
9 words
A compound of claim 7 wherein R is n-hexyl.
Claim 13
Dependent Claim
26 words
An analgesic composition consisting essentially of an inert, physiologically compatible carrier and an analgesic-effective amount of a compound claimed in any of claims 1 to 11.
Claim 14
Dependent Claim
12 words
A composition of claim 12 containing a compouna wherein R is n-pentyl.
Claim 15
Dependent Claim
12 words
A composition of claim 12 containing a compound wherein R is n-propyl.
Claim 16
Dependent Claim
12 words
A composition of claim 12 containing a compouna wherein R is n-butyl.
Claim 17
Dependent Claim
12 words
A composition of claim 12 containing a compound wherein R is n-hexyl.
Claim 18
Dependent Claim
27 words
A pharmaceutical composition for raising the pain thresholo in warm-blooded animals which comprises an effective amount of a compound claimed in any of claims 1 to 11.
References Cited (Backward Citations)
No citation records indexed.
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