EP0106107A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Sheet-shape adhesive preparation
Assignee: Kaken Pharmaceutical Co Ltd
•
Filing: 1983-09-05
•
Granted: —
•
Expires: 2003-09-05
Abstract
Abstract A sheet-shape adhesive preparation for promoting tooth-movement in orthodontics comprising a layer of a pharmaceutical composition containing as the active ingredient a prostaglandin (e.g. prostaglandin E 1 , prostaglandin E 2 , and prostaglandin F 2α ) in admixture with one or more high molecular weight compounds and a flexible base sheet, a process for the preparation thereof, and a method for promoting tooth-movement in orthodontics by applying the sheet-shape adhesive preparation to the mucous membrane of gingiva. Said preparation can be kept for a long period of time without being dissolved in saliva and without irritation or unpleasant feeling when applied to the mucous membrane of gingiva and hence can show the tooth-movement activity of the active prostaglandin for a long period of time.
Inventors
- 👤 Terushige Kawata
- 👤 Shinsuke Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 05:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K31/00; A61K31/557; A61K6/00; A61K6/60; A61K6/65; A61K6/66; A61K6/69
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
39 words
A sheet-shape adhesive preparation for promoting tooth-movement in orthodontics, which comprises a layer of a pharmaceutical composition containing as an active ingredient a prostaglandin in admixture with one or more high molecular weight compounds and a flexible base sheet.
Claim 2
Dependent Claim
39 words
A sheet-shape adhesive preparation for promoting tooth-movement in orthodontics, which comprises a layer of a pharmaceutical composition containing as an active ingredient a prostaglandin in admixture with one or more high molecular weight compounds and a flexible base sheet.
Claim 3
Dependent Claim
21 words
The preparation according to claim I, wherein the prostaglandin is contained in an amount of 1 to 1,000 µg/cm 2 .
Claim 4
Dependent Claim
25 words
The preparation according to claim 1, wherein the layer oi a pharmaceutical composition has a thickness of 50 to 2, 000 µ in dry state.
Claim 5
Dependent Claim
110 words
The preparation according to claim-1, wherein the high molecular weight compound is a combination of a water-soluble high molecular weight compound having a low dissolution rate in water selected from the group consisting of gelatin, albumin, karaya gum, agar and gluten; a water-soluble high molecular weight compound having a high dissolution rate in water selected from the group consisting of an alkali metal salt of polyacrylic acid, an alkali metal salt of alginic acid, hydroxyethyl cellulose, sodium carboxymethyl cellulose, starch, polyvinyl alcohol, and polyvinylpyrrolidone; and a water-insoluble high molecular weight compound selected from the group consisting of vinyl acetate resin, ethyl cellulose, propyl cellulose, ethylmethyl cellulose, and cellulose acetate phthalate.
Claim 6
Dependent Claim
88 words
The preparation according to claim 4, wherein the water-soluble high molecular weight compound having a high dissolution rate in water is incorporated in an amount of 5 to 40 % by weight based on the weight of the pharmaceutical composition (in dry state), and the water-solution high molecular weight compound having a low dissolution rate in water and the water-insoluble high molecular weight compound are totally incorporated in an amount of 20 to 70 % by weight based on the weight of the pharmaceutical composition (in dry state).
Claim 7
Dependent Claim
40 words
The preparation according to claim 5, wherein the water-insoluble high molecular weight compound and the water-soluble high molecular weight compound having a low dissolution rate is incorporated in the ratio of 1 : 9 to 6 : 4 by weight.
Claim 8
Dependent Claim
27 words
The preparation according to claim 1, wherein the layer of the pharmaceutical composition is dried till the water content is not more than 20 % by weight.
Claim 9
Dependent Claim
49 words
The preparation according to claim 1, wherein the pharmaceutical composition is also incorporated with a softening agent selected from the group consiting of glycerin, propylene glycol, polyethylene glycol, 1,3-butanediol, and sorbitol in an amount of 5 to 50 % by weight based on the pharmaceutical composition (in dry state).
Claim 10
Dependent Claim
116 words
A process for the preparation of a sheet-shape adhesive preparation for promoting tooth-movement in orthodontics, which comprises dissolving one or more water-soluble high molecular weight compounds having a low dissolution rate in water, adding thereto one or more water-insoluble high molecular weight compounds and further additng a water-soluble high molecular weight compound having a high dissolution rate to give a homogeneous aqueous mixture, adding thereto an aqueous solution of a prostaglandin in a softening agent to give a pharmaceutical composition containing as an active ingredient a prostaglandin, spreading the pharmaceutical composition on a flexible base sheet, and drying the resultant to form a layer of the pharmaceutical composition in the sheet-like state on the base sheet.
Claim 11
Dependent Claim
116 words
A process for the preparation of a sheet-shape adhesive preparation for promoting tooth-movement in orthodontics, which comprises dissolving one or more water-soluble high molecular weight compounds having a low dissolution rate in water, adding thereto one or more water-insoluble high molecular weight compounds and further additng a water-soluble high molecular weight compound having a high dissolution rate to give a homogeneous aqueous mixture, adding thereto an aqueous solution of a prostaglandin in a softening agent to give a pharmaceutical composition containing as an active ingredient a prostaglandin, spreading the pharmaceutical composition on a flexible base sheet, and drying the resultant to form a layer of the pharmaceutical composition in the sheet-like state on the base sheet.
Claim 12
Dependent Claim
107 words
The process according to claim 9, wherein the water-soluble high molecular weight compound having a low dissolution rate is a member selected from the group consisting of gelatin, albumin, karaya gum, agar and gluten; the water-soluble high molecular weight compound having a high dissolution rate is a member selected from the group consisting of an alkali metal salt of polyacrylic acid, an alkali metal salt of alginic acid, hydroxyethyl cellulose, sodium carboxymethyl cellulose, starch, polyvinyl alcohol, and polyvinylpyrrolidone; and the water-insoluble high molecular weight compound is a member selected from the group consisting of vinyl acetate resin, ethyl cellulose, propyl cellulose, ethylmethyl cellulose, and cellulose acetate phthalate.
Claim 13
Independent Claim
49 words
A method for promoting tooth-movement in orthodontics, which comprises applying a sheet-shape adhesive preparation comprising a layer of a pharmaceutical composition containing as an active ingredient a prostaglandin in admixture with one or more high molecular weight compounds and a flexible base sheet to the mucous membrane of gingiva.
Claim 14
Independent Claim
49 words
A method for promoting tooth-movement in orthodontics, which comprises applying a sheet-shape adhesive preparation comprising a layer of a pharmaceutical composition containing as an active ingredient a prostaglandin in admixture with one or more high molecular weight compounds and a flexible base sheet to the mucous membrane of gingiva.
Claim 15
Dependent Claim
30 words
The method according to claim 11, wherein the prostaglandin is a member selected from the group consisting of prostaglandin E 1 , prostaglandin E 2 and prostaglandin F 2d .
Claim 16
Dependent Claim
24 words
The method according to claim 11, wherein the prostaglandin is contained in the preparation in an amount of 1 to 1,000 µg/cm 2 .
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.