Therapeutic dipeptides

Claim 1

-1. A compound of the formula wherein A and A' are independently hydroxy, lower alkoxy, lower alkenoxy, di-lower alkylamino, lower alkoxy, acylamino lower alkoxy, acyloxy lower alkoxy, aryloxy, aryl-lower alkyloxy, amino, lower alkylamino, di-lower alkylamino,aryl-lower alkylamino, hydroxyamino, or substituted aryloxy, or substituted aryl-lower alkoxy wherein the substituent is methyl, halo or methoxy; R 1 , R 2 , R 3 , R 4 and R 5 taken separately are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted alkyl, alkenyl, or alkynyl groups in which the substituents are hydroxy, alkoxy, halo, guanidino, amino, alkylamino, mercapto, or alkylmercapto, substituted cycloalkyl groups in which the substituents are alkyl, halo, haloalkyl, hydroxy, alkylamino, nitro or trifluoromethyl, and substituted aryl and heterocyclic groups in which the substituents are alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, or trifluoromethyl; R 1 and R 2 when taken together with the carbon and nitrogen to which they are respectively attached and R 2 and R 3 when taken together with the nitrogen and carbon to which they are respectively attached form an N-heterocyclic containing from 3 to 5 carbon atoms or 2 to 4 carbon atoms and a sulfur or nitrogen atom; M is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl; M' is hydrogen, lower alkyl, cycloalkyl, phenyl, phenyl lower alkyl, hydroxy phenyl lower alkyl, hydroxy lower alkyl, amino lower alkyl, guanidino lower alkyl, imidazolyl lower alkyl, indolyl lower alkyl, mercapto lower alkyl or lower alkyl mercapto lower alkyl; M and M' when taken together form an alkylene bridge of from 2 to 5 carbon atoms; an alkylene bridge of from 2 to 5 carbon atoms and one sulfur atom; an alkylene bridge of from 3 to 4 carbon atoms containing a double bond; a substituted alkylene bridge containing from 2 to 5 carbon atoms in which the substituent is hydroxy, lower alkoxy, or lower alkyl; or fused aralkylene; M and M' when taken with the carbon and nitrogen to which they are respectively attached form a tetrahydroisoquinoline, dihydroindole or pyrrolidine ring; wherein n is 2, 3 or 4 and n' is 1, 2 or 3; X is or A r is arylene or substituted arylene containing one or two substituents H, halo, CF 3 , lower alkyl, OH , loweralkoxy, mercapto, amino or sulfamyl; and pharmaceutically-acceptable salts thereof.