EP0103946A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Method for inhibiting mineralization of natural tissue during implantation
Assignee: Janssen Pharmaceuticals Inc
•
Filing: 1983-07-04
•
Granted: —
•
Expires: 2003-07-04
Abstract
Abstract Natural tissues fixed with a tanning solution such as glutaraldehyde and intended for implantation in humans, e.g., porcine heart valve prosthetic devices, are treated with a solution of a water soluble quaternary ammonium salt such as dodecyltrimethylammonium chloride to inhibit mineralization, particularly calcification, of the tissue after implantation.
Inventors
- 👤 Elisabeth Marie Pollock
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 22:08
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
51 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble quaternary ammonium salt whose nitrogen atom has at least one alkyl group containing from 7 to 15 carbon atoms.
Claim 2
Independent Claim
51 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble quaternary ammonium salt whose nitrogen atom has at least one alkyl group containing from 7 to 15 carbon atoms.
Claim 3
Dependent Claim
19 words
The method of Claim 1 wherein the aqueous solution has a pH of from about 2.0 to about 10.0.
Claim 4
Independent Claim
26 words
The method of Claim 1or 2 wherein the counter-ion of the quaternary ammonium salt is selected from the group consisting of chloride ion and methylsulfate ion.
Claim 5
Dependent Claim
18 words
The method of Claim 1, 2, or 3 wherein the substituent group is a straight chain aliphatic group.
Claim 6
Dependent Claim
17 words
The method of Claim 1, 2, or 3 wherein the substituent group is a branched aliphatic group.
Claim 7
Independent Claim
27 words
The method of Claim 1or 2 wherein the water soluble quaternary ammonium salt is selected from the group consisting of decyltrimethylammonium chloride, dodecyltrimethylammonium chloride and myristyltrimethylammonium chloride.
Claim 8
Independent Claim
32 words
The method of any one of Claims 1 to 6wherein said natural tissue is contacted with said solution for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 9
Independent Claim
29 words
The method of any one of Claims 1 to 7 wherein said tissue is contacted with said solution for a period of at least 24 hours at ambient temperature.
Claim 10
Independent Claim
27 words
The method of any one of Clairms 1 to 8 wherein the concentration of said salt in said solution is from about 0.1 to 5% by weight.
Claim 11
Independent Claim
27 words
The method of any one of Clairms 1 to 8 wherein the concentration of said salt in said solution is from about 0.1 to 5% by weight.
Claim 12
Independent Claim
57 words
The method of any one of Claims 1to 9 wherein said solution comprises, in addition to said quaternary ammonium salt, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 13
Independent Claim
58 words
The method of any one of Claims 1 to 10 wherein said solution comprises, in addition to said quaternary ammonium salt, about 0.8% by weight of sodium chloride, about 0.04% by weight of potassium chloride, about 0.02% by weight each . of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 14
Dependent Claim
18 words
The.method of any one of Claims 1 to 11 wherein the solution has a pH of about 7.
Claim 15
Independent Claim
44 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising dodecyltrimethylammonium chloride for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 16
Independent Claim
44 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising dodecyltrimethylammonium chloride for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 17
Dependent Claim
18 words
The method of Claim 13 wherein said solution comprises from about 0.1 to 5% by weight dodecyltrimethylammonium chloride.
Claim 18
Dependent Claim
24 words
The method of Claim 13 or 14 wherein said tissue is contacted with said solution for a time of at least about 7 days.
Claim 19
Independent Claim
58 words
The method of any one of Claims 13 to 15 wherein said solution comprises, in addition to said quaternary anmonium salt, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 20
Independent Claim
56 words
The method of any one of Claims13 to 16 wherein said solution conprises, in addition to said quaternary ammonium salt, about 0.8% by weight of sodium chloride, about 0.04% by weight of potassium chloride, about 0.02% by weight each of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 21
Independent Claim
19 words
The method of any one of Claims 13 to 17 wherein the pH of said solution is about 7.0.
Claim 22
Independent Claim
19 words
The method of any one of Claims 13 to 18 wherein the concentration of dodecyltrimethylammonium chloride is about 1%.
Claim 23
Independent Claim
31 words
The method of any one of Claims 13 to 19 wherein the tissue is contacted with said solution of dodecyltrimethylammonium chloride for a period of about 7 days at ambient temperature.
Claim 24
Independent Claim
20 words
The method of any one of Claims 13 to 20 wherein the fixed tissue is a glutaraldehyde-fixed porcine heart valve.
Claim 25
Independent Claim
17 words
The method of any one of Claims 13 to 21 wherein said living body is a human.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.