Heterocyclic compounds

Abstract

Abstract 1. Heterocyclic compounds corresponding to the following formula see diagramm : EP0101897,P15,F1 in which R is Cl, Br, -CN or -OH ; X is O, S or see diagramm : EP0101897,P14,F2 where R1 is hydrogen, C1 -C6 alkyl, C3 -C7 cycloalkyl, phenyl, naphtyl, phenyl-C1 -C4 -alkyl, naphthyl-C-C4 -alkyl, (C1 -C6 -alkyl)-carbonyl, benzoyl and the C1 -C6 alkyl radicals and (C1 -C6 -alkyl)-carbonyl radicals mentioned for R1 may be substituted by -OH, -CN, C1 -C6 alkoxy, phenoxy, halogen, amino, carbamoyl, sulfamoyl, (C1 -C6 -alkyl)-carbonyloxy, (C1 -C6 -alkoxy)-carbonyl, the C3 -C7 cycloalkyl radical by halogen, C1 -C6 alkyl, -OH, -CN, phenyl, the phenyl, naphthyl, benzoyl radicals and the phenyl-C1 -C4 -alkyl and naphtyl-C1 -C4 -alkyl radicals in the aryl part by halogen, C1 -C6 alkyl, C1 -C6 alkoxy, -CN, -OH ; Y is a 5- to 7-membered heterocyclic radical which may contain 1, 2 or 3 atoms from series O, N, S and which may be fused, the radicals mentioned for Y optionally being substituted by halogen, C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 alkylthio, -NO2 , (C1 -C6 -alkoxy)-carbonyl, carbamoyl, amino, sulfamoyl or representing a 3-phenyl-1,2,4-thiadiazol-5-yl radical ; Z is Cl, Br, -CN, R2 , T or R'2 where R2 is hydrogen, C1 -C6 alkyl which may be substituted by -OH, -CN, C1 -C6 alkoxy, phenoxy, halogen, amino, carbamoyl, sulfamoyl, (C1 -C6 -alkyl)-carbonyloxy, (C1 -C6 -alkoxy)-carbonyl, C3 -C7 cycloalkyl which may be substituted by halogen, C1 -C6 alkyl, -OH, -CN, phenyl ; phenyl and naphthyl or phenyl-C1 -C4 -alkyl and naphthyl-C1 -C4 -alkyl, the aryl radicals optionally being substituted by halogen, C1 -C6 alkyl, C1 -C6 alkoxy, -CN, -OH, R'2 is phenyl, naphthyl, phenyl-C1 -C4 -alkyl, naphthyl-C1 -C4 -alkyl, the aryl radicals optionally being substituted as indicated above in connection withe R2 and T represents O, S, see diagramm : EP0101897,P16,F3 R3 has the same meanings as R2 and, where the structural feature see diagramm : EP0101897,P16,F4 is present, R2 and R3 together with the N atom may form a 5- to 7-membered ring, with the proviso that a) where R is -CN and X is see diagramm : EP0101897,P16,F5 Z is not R2 -O- and b) where R is -CN and X is O, Y represents see diagramm : EP0101897,P16,F6 where Hal is halogen, preferably chlorine and bromine, and R4 is hydrogen, C1 -C6 alkyl or phenyl and c) the compound see diagramm : EP0101897,P16,F7 is excepted from this claim.

Inventors

• 👤 Florin Dr. Seng
• 👤 Uwe Dr. Claussen
• 👤 Gunther Dr. Beck
• 👤 Klaus Dr. Sasse

Bibliographic Details