Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
90 words
A peptide having the formula:-X-β-D-2NAL-R 2 -D-Trp-Ser-R 5 -R 6 -R 7 -Arg-Pro-R 10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R 2 is Cl-D-Phe, F'-D-Phe, NO 2 -D-Phe, Cl 2 -D- phe or Br-D-Phe; R 5 is Tyr or 2-Cl-Phe; R 6 is 4-NH2-D-Phe or D-Arg; R 7 is Leu or N α Me-Leu; and R 10 is Gly-NH 2 , NHCH 2 CH 3 D-Ala-NH 2 , Gly-OCH 3 , Gly-OCH 2 CH 3 , Gly-NHNH 2 or Sar-NH 2 .
Claim 2
Dependent Claim
90 words
A peptide having the formula:-X-β-D-2NAL-R 2 -D-Trp-Ser-R 5 -R 6 -R 7 -Arg-Pro-R 10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R 2 is Cl-D-Phe, F'-D-Phe, NO 2 -D-Phe, Cl 2 -D- phe or Br-D-Phe; R 5 is Tyr or 2-Cl-Phe; R 6 is 4-NH2-D-Phe or D-Arg; R 7 is Leu or N α Me-Leu; and R 10 is Gly-NH 2 , NHCH 2 CH 3 D-Ala-NH 2 , Gly-OCH 3 , Gly-OCH 2 CH 3 , Gly-NHNH 2 or Sar-NH 2 .
Claim 3
Dependent Claim
76 words
A peptide or a nontoxic salt thereof, said peptide having the formula: wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R 2 is Cl-D-Phr, F-I)-Phe, NO 2 -D-Phe, Cl 2 -D-Phe or Br-D-Phe; R 5 is Tyr or 2-Cl-Phe; R 6 is 4-NH 2 -D-Phe or D-Arg; R 7 is Leu or N α Me-Leu; and R 10 is Gly-NH 2 , NHCH 2 CH 3 or D-Ala-NH 2 .
Claim 4
Dependent Claim
76 words
A peptide or a nontoxic salt thereof, said peptide having the formula: wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R 2 is Cl-D-Phr, F-I)-Phe, NO 2 -D-Phe, Cl 2 -D-Phe or Br-D-Phe; R 5 is Tyr or 2-Cl-Phe; R 6 is 4-NH 2 -D-Phe or D-Arg; R 7 is Leu or N α Me-Leu; and R 10 is Gly-NH 2 , NHCH 2 CH 3 or D-Ala-NH 2 .
Claim 5
Dependent Claim
17 words
A peptide in accordance with Claim 1 or Claim 2 wherein R 2 is 4-Cl-D-Phe or 4-F-D-Phe.
Claim 6
Dependent Claim
12 words
A peptide in accordance with Claim 3 wherein R 7 is Leu.
Claim 7
Dependent Claim
12 words
A peptide in accordance with Claim 4 wherein R 6 is D-Arg.
Claim 8
Dependent Claim
12 words
A peptide in accordance with Claim 5 wherein R 5 is Tyr.
Claim 9
Dependent Claim
13 words
A peptide in accordance with Claim 6 wherein X is Ac or Acr.
Claim 10
Dependent Claim
21 words
A peptide in accordance with any one of Claims 1 to 3 wherein X is Ac and R 6 is D-Arg.
Claim 11
Dependent Claim
9 words
A peptide as defined in the foregoing specific Example.
Claim 12
Dependent Claim
9 words
A peptide as defined in the foregoing specific Example.
Claim 13
Dependent Claim
18 words
A non-toxic salt of a peptide as claimed in any one of Claims 1 and 3 to 9.
Claim 14
Dependent Claim
41 words
A pharmaceutical composition for regulating the secretion of gonadotropins comprising as an active ingredient an effective amount of a peptide as defined in Claim 1, or a non-toxic salt thereof, in association with a major amount of a non-toxic pharmaceutically-acceptable diluent.