EP0097050A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Esters of phosphinylalkanoyl substituted prolines
Assignee: ER Squibb and Sons LLC
•
Filing: 1983-06-13
•
Granted: —
•
Expires: 2003-06-13
Abstract
Abstract Hypotensive activity is exhibited by new compounds having the formula and salts thereof wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl or phenyl; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are -XCH 2 CH 2 X-; and X is R 7 is hydrogen or and n is 0 or 1.
Inventors
- 👤 John Krapcho
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 23:56
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; A; A61; A61P; A61P9/00; A61P9/12; C07F9/28; C07F9/30; C07F9/32; C07F9/3258; C07F9/3264; C07F9/553; C07F9/572; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
90 words
A compound having the formula or a salt thereof, wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl, or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl or phenyl; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are -XCH 2 CH 2 X-; and X is -S-, or R 7 is hydrogen or and n is 0 or 1.
Claim 2
Dependent Claim
90 words
A compound having the formula or a salt thereof, wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl, or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl or phenyl; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are -XCH 2 CH 2 X-; and X is -S-, or R 7 is hydrogen or and n is 0 or 1.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is cycloalkyl.
Claim 4
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is 3-cyclohexyl.
Claim 5
Dependent Claim
14 words
A compound in accordance with claim 1 wherein R 2 is 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl.
Claim 6
Dependent Claim
16 words
A compound in accordance with claim 1, 2, 3 or 4 wherein R 1 is 4-phenylbutyl.
Claim 7
Dependent Claim
17 words
A compound in accordance with any one of claims 1 to 5 wherein R 4 is hydrogen.
Claim 8
Dependent Claim
17 words
A compound in accordance with any one of claims 1 to 6 wherein R 7 is hydrogen.
Claim 9
Dependent Claim
16 words
A compound in accordance with any one of claims 1 to 7 wherein n is 0.
Claim 10
Dependent Claim
14 words
The compound in accordance with claim 1, (S)-7-[[[cyclohexyl(l-oxopropoxy)methoxy](4-phenylbutyl)phosphinyl]acetyl]-l,4-dithia-7- azaspiro[4.4]nonane-8-carboxylic acid, or a salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.