EP0095163A2
Expired / Lapsed
EP
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2-Oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition
Assignee: Tanabe Pharma Corp
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Filing: 1983-05-20
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Granted: —
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Expires: 2003-05-20
Abstract
Abstract Novel 2-oxo-imidazolidine derivative of the formula: wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, pharmaceutically acceptable salts thereof and processes for preparing the same are disclosed. In form of pharmaceutical compositions said compounds (I) and salts thereof exhibit hypotensive activity.
Inventors
- 👤 Naoto Yoneda
- 👤 Jyoji Kato
- 👤 Kimiaki Hayashi
- 👤 Takashi Ochiai
- 👤 Keizo Kinashi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 17:53
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61P; A61P35/00; A61P43/00; A61P9/00; A61P9/12; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/30; C07D233/32; A61K; A61K38/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
46 words
A compound of the formula: wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
46 words
A compound of the formula: wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
59 words
The compound claimed in Claim 1, in which R 1 is alkyl of one to four carbon atoms or benzyl, R 2 is alkyl of one to four carbon atoms, R 3 is straight or branched alkyl of 4 to 8 carbon atoms, benzyl or phenethyl and R 4 is hydrogen or alkyl of one to four carbon atoms.
Claim 4
Dependent Claim
38 words
The compound claimed in Claim 1, in which R 1 is methyl, n-butyl or benzyl, R 2 is methyl or ethyl, R 3 is isobutyl, isopentyl, n-octyl, benzyl or phenethyl and R 4 is hydrogen, ethyl or n-butyl.
Claim 5
Dependent Claim
29 words
The compound claimed in Claim 1, in which R 1 is methyl, R 2 is methyl, R 3 is n-octyl or phenethyl and R 4 is hydrogen or ethyl.
Claim 6
Dependent Claim
17 words
The compound claimed in Claim 1 which is (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)aminol- propionyl}-2-oxo-imidazolidine-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
16 words
The compound claimed in Claim 1 which is (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
16 words
The compound claimed in Claim 1 which is (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
17 words
The compound claimed in Claim 1 which is (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-n-nonyl)amino]propionyl}-2-oxo- imidazolidine-4-carboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
130 words
A process for preparing a compound of the formula: wherein R1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, which comprises the steps of subjecting a compound of the formula: wherein R 5 is a protecting group capable of being removed by acid treatment or catalytic hydrogenation, R 6 is lower alkyl or a protecting group capable of being removed by acid treatment or catalytic hydrogenation and R 1 , R 2 and R 3 are the same as defined above, to acid treatment and/or catalytic hydrogenation, and if required, further converting the product to a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
130 words
A process for preparing a compound of the formula: wherein R1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, which comprises the steps of subjecting a compound of the formula: wherein R 5 is a protecting group capable of being removed by acid treatment or catalytic hydrogenation, R 6 is lower alkyl or a protecting group capable of being removed by acid treatment or catalytic hydrogenation and R 1 , R 2 and R 3 are the same as defined above, to acid treatment and/or catalytic hydrogenation, and if required, further converting the product to a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
62 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound of the formula: wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
Claim 13
Dependent Claim
62 words
A pharmaceutical composition which comprises a therapeutically effective amount of a compound of the formula: wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
Claim 14
Dependent Claim
67 words
A compound of the formula: wherein R1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl, R 5 is a protecting group capable of being removed by acid treatment or catalytic hydrogenation and R 6 is lower alkyl or a protecting group capable of being removed by acid treatment or catalytic hydrogenation.
Claim 15
Dependent Claim
67 words
A compound of the formula: wherein R1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R 3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl, R 5 is a protecting group capable of being removed by acid treatment or catalytic hydrogenation and R 6 is lower alkyl or a protecting group capable of being removed by acid treatment or catalytic hydrogenation.
References Cited (Backward Citations)
No citation records indexed.
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