1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives

Claim 1

Compounds of the general Formula I wherein X is CH or N; Y is hydrogen, hydroxy, benzyloxy, amino, sulfamyl, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms, carboxylic acyl having from 2 to 6 carbon atoms, alkylS(O) m - having from 1 to 6 carbon atoms wherein m is 0, 1 or 2, trifluoromethyl, trifluoromethylthio, or COOA wherein A is hydrogen, alkyl having from 1 to 6 carbon atoms or a pharmaceutically acceptable cation derived from a metal or an amine; Z is hydrogen, hydroxy, halogen, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms, hydroxyalkyl having from 1 to 6 carbon atoms or carboxylic acyloxy having from 2 to 6 carbon atoms; R 1 is alkenyl having from 2 to 10 carbon atoms, alkynyl having from 2 to 10 carbon atoms, cycloalkyl having from 3 to 7 carbon atoms, cycloalkenyl having from 5 to 8 carbon atoms, 2-, 4- or 5-pyrimidyl, 2-, 3-or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furanyl, carboxylic acyl having from 2 to 6 carbon atoms, or alkyl having from 1 to 10 carbon atoms which alkyl may be substituted with hydroxy, halogen, alkoxy having from 1 to 6 carbon atoms, carboxylic acyl having from 2 to 6 carbon atoms, phenyl, 2-, 3- or 4-pyridyl, 2-, 4- or 5- pyrimidyl, 2- or 3-thienyl, 2- or 3-furanyl, cycloalkyl having from 3 to 7 carbon atoms or carboxylic acyloxy having from 1 to 6 carbon atoms. R 2 is hydrogen, carboxylic acyl having from 1 to 6 carbon atoms, alkyl having from 1 to 6 carbon atoms, hydroxyalkyl having 2 to 6 carbon atoms, dihydroxyalkyl having from 2 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, R a R b N(CH 2 ) n - wherein n is an integer of from 2 to 6, R a and R b are hydrogen, alkyl having from 1 to 6 carbon atoms or form, together with the nitrogen atom to which they are attached, a piperidine, morpholine, piperazine or pyrrolidine ring or R 2 represents a pharmaceutically acceptable cation derived from a metal or an amine, with the proviso that when X is CH, R 2 is hydrogen or carboxylic acyl, Y is hydrogen, alkyl, alkoxy, CF 3 , CH 3 SO 2 , ―SCF 3 or NO 2 and Z is hydrogen, halogen, alkyl or alkoxy, then R 1 is not unsubstituted alkyl; the acid addition salts and hydrates and solvates of such compounds.