EP0089245A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
A stable interferon beta composition and a method of stabilizing interferon beta
Assignee: Inter-Yeda Ltd
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Filing: 1983-03-16
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Granted: —
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Expires: 2003-03-16
Abstract
Abstract This invention relates to a method of stabilizing Interferon beta (Human Fibroblast Interferon (HFIF)), wherein a highly purified Interferon beta solution, admixed with known excipients therefor, is dialysed against an acetate buffer at pH 3.5 for about 48 hours. The resulting Interferon beta solution is admixed with from 0.5% to 10% wt/volume of polyvinyl pyrrolidone prior to or following filtration through a sterile filter, dispensed into glass vials, lyophilized, and the vials are sealed in vacuo and stored at 4 DEG C.
Inventors
- 👤 Samuel Cymbalisto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 03:10
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/215; A61K47/00; A61K47/30; A61K47/32
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
28 words
A stable Interferon β composition comprising a buffered solution of highly purified Interferon and conventional excipients, said solution being stabilized by 0.5 to 10% wt/volume of polyvinyl pyrrolidone.
Claim 2
Dependent Claim
28 words
A stable Interferon β composition comprising a buffered solution of highly purified Interferon and conventional excipients, said solution being stabilized by 0.5 to 10% wt/volume of polyvinyl pyrrolidone.
Claim 3
Dependent Claim
17 words
A composition as claimed in Claim ' 1, wherein the excipients are mannitol and human serum albumin.
Claim 4
Dependent Claim
21 words
A composition as claimed in Claim 1 or 2, wherein the buffer is an acetate buffer having a pH of 3.5.
Claim 5
Dependent Claim
21 words
A composition as claimed in any one of the preceding claims packaged in a glass vial, lyophilized and sealed in vacuo.
Claim 6
Independent Claim
66 words
A method of stabilizing Interferon β , wherein a highly purified Interferon β solution, admixed with known excipients therefor, is dialysed against an acetate buffer solution, the resulting Interferon solution is admixed with from 0.5 to 10% wt/volume of polyvinyl pyrrolidone prior to or following filtration through a sterile filter, dispensed into glass vials, lyophilized, and the vials are sealed in vacuo and stored at 4°C.
Claim 7
Independent Claim
66 words
A method of stabilizing Interferon β , wherein a highly purified Interferon β solution, admixed with known excipients therefor, is dialysed against an acetate buffer solution, the resulting Interferon solution is admixed with from 0.5 to 10% wt/volume of polyvinyl pyrrolidone prior to or following filtration through a sterile filter, dispensed into glass vials, lyophilized, and the vials are sealed in vacuo and stored at 4°C.
Claim 8
Dependent Claim
14 words
A stabilized Interferon β composition whenever obtained by the method claimed in Claim 5.
References Cited (Backward Citations)
No citation records indexed.
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