EP0085261A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Home diagnostic aid and method for determining the presence of occult blood for use by the general public
Assignee: HEMATEC Corp
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Filing: 1982-12-31
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Granted: —
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Expires: 2002-12-31
Abstract
Abstract A guaiac reagent-based diagnositic aid for determining the presence of occult blood in an aqueous system contains a micron-sized silica gel into which a guaiac solution has been adsorbed. The guaiac-containing carrier is contacted with a dry, particulate, oxidizing agent, such as a monopersulfate compound, to form a single composition. This composition can be packaged in a water-pervious sandwich. Upon contact with water, the oxidizing agent is activated to produce hydrogen peroxide, which in the presence of occult blood will oxidize the adsorbed guaiac to a brilliant blue reaction product.
Inventors
- 👤 Henry J. Wells
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 17:29
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; G01N33/721; G01N33/725
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
79 words
A diagnostic aid, characterised in that it comprises an adsorbent or absorbent carrier having adsorbed thereon or absorbed therein a solution of guaiac in a solvent therefor, and an oxidizing agent in contact with said carrier, said oxidizing agent being capable of oxidizing said guaiac to a blue dye in the presence of water and hemoglobin, and said oxidizing agent in the absence of water being substantially non-reactive with said guaiac when adsorbed onto or absorbed into said carrier.
Claim 2
Dependent Claim
79 words
A diagnostic aid, characterised in that it comprises an adsorbent or absorbent carrier having adsorbed thereon or absorbed therein a solution of guaiac in a solvent therefor, and an oxidizing agent in contact with said carrier, said oxidizing agent being capable of oxidizing said guaiac to a blue dye in the presence of water and hemoglobin, and said oxidizing agent in the absence of water being substantially non-reactive with said guaiac when adsorbed onto or absorbed into said carrier.
Claim 3
Dependent Claim
23 words
A diagnostic aid as claimed in Claim 1, further comprising water-pervious container means for holding said carrier and said agent in mutual contact.
Claim 4
Dependent Claim
29 words
A diagnostic aid as claimed in Claim 2, wherein said container means comprises first and second sheets of porous paper between which are located said carrier and said agent.
Claim 5
Dependent Claim
26 words
A diagnostic aid as claimed in any of Claims 1 to 3, wherein said solvent is a lower aliphatic alcohol, chloroform, benzene, or a mixture thereof.
Claim 6
Dependent Claim
23 words
A diagnostic aid as claimed in Claim 4, wherein said solvent is an alkanol or alkenol having from one to six carbon atoms.
Claim 7
Dependent Claim
18 words
A diagnostic aid as claimed in Claim 5 wherein said solvent comprises methanol, isopropanol, or a mixture thereof.
Claim 8
Dependent Claim
43 words
A diagnostic aid as claimed in any of Claims 1 to 6, wherein said guaiac is present in said solution in an amount of from one percent to five percent by weight of solution before being adsorbed onto or absorbed into said carrier.
Claim 9
Dependent Claim
30 words
A diagnostic aid as claimed in Claim 7, wherein said guaiac is present in said solution in an amount of from one percent to three percent by weight of solution.
Claim 10
Dependent Claim
30 words
A diagnostic aid as claimed in any of Claims 1 to 8, wherein the weight ratio of said oxidizing agent to said carrier is from about 1:3 to about 3:1.
Claim 11
Dependent Claim
17 words
A diagnostic aid as claimed in any of Claims 1 to 9, wherein said carrier is particulate.
Claim 12
Dependent Claim
22 words
A diagnostic aid as claimed in Claim 10, wherein said carrier is dry, after said solution is adsorbed thereon or absorbed therein.
Claim 13
Dependent Claim
30 words
A diagnsotic aid as claimed in Claim 10 or 11, wherein said carrier is silica gel or other adsorbent or absorbent silica-based material, or calcium phosphate or a mixture thereof.
Claim 14
Dependent Claim
18 words
A diagnostic aid as claimed in any of Claims 1 to 12, wherein said oxidizing agent is particulate.
Claim 15
Dependent Claim
28 words
A diagnostic aid as claimed in Claim 13, wherein said oxidizing agent is potassium persulfate or other monopersulfate compound, cumene hydroperoxide, tertiary butyl hydroperoxide, or a mixture thereof.
Claim 16
Dependent Claim
25 words
A diagnostic aid as claimed in Claim 14, wherein said oxidizing agent is a triple salt of potassium monopersulfate, potassium hydrogen sulfate and potassium sulfate.
Claim 17
Dependent Claim
26 words
A diagnostic aid as claimed in any of Claims 10 to 15, wherein said carrier and said oxidizing agent are both particulate, and are in admixture.
Claim 18
Dependent Claim
29 words
A diagnostic aid as claimed in any of Claims 1 to 12, wherein said oxidizing agent is in liquid form, and is adsorbed onto or absorbed into a carrier.
Claim 19
Dependent Claim
26 words
A diagnostic aid as claimed in Claim 17, wherein said oxidizing agent and said solution of guaiac are adsorbed onto or absorbed into a common carrier.
Claim 20
Dependent Claim
36 words
A diagnostic aid as claimed in any of Claims 1 to 12, wherein said oxidizing agent is in solution in a solvent therefor, said oxidizing agent in solution being adsorbed onto or absorbed into a carrier.
Claim 21
Dependent Claim
28 words
A diagnostic aid as claimed in Claim 19, wherein said oxidizing agent is cumene hydroperoxide, tertiary butyl hydroperoxide, barium peroxide, strontium peroxide, magnesium peroxide, or a mixture thereof.
Claim 22
Dependent Claim
19 words
A diagnostic aid as claimed in any of Claims 17 to 19, wherein said oxidizing agent is hydrogen peroxide.
Claim 23
Independent Claim
49 words
A method of determining the presence of hemoglobin in an aqueous medium, characterised in that it comprises contacting the aqueous medium with a diagnostic aid as claimed in any of Claims 1 to 21 and determining whether a portion of the carrier of said diagnostic aid is dyed blue.
References Cited (Backward Citations)
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