EP0085166A1
Expired / Lapsed
EP
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A filter and a process for the preparation thereof
Assignee: New York Blood Center
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Filing: 1982-12-15
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Granted: —
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Expires: 2002-12-15
Abstract
Abstract There is disclosed a filter comprising fibrin in gel form, the gel having substantially uniform pore sizes, and the filter comprising means for retaining the shape of at least one surface of the gel against deformation when contacted by a flowing medium.
Inventors
- 👤 Birger Blomback
- 👤 Masahisa Okada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 12:31
CPC Classifications
B; B01; B01J; B01J31/00; B01J31/003; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/15; B01D; B01D39/00; B01D69/00; B01D69/10; B01D69/107; B01D69/1071; B01D71/00; B01D71/06; B01D71/74; B01J31/02; B01J31/06; B01J35/00; B01J35/50; B01J35/56; C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C12; C12N; C12N1/00; C12N1/02; C12N11/00; C12N11/02; C12N11/04; C12N7/00; A61K38/00; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18811; C12N2760/18851; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
38 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium.
Claim 2
Dependent Claim
38 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium.
Claim 3
Dependent Claim
15 words
A filter according to claim 1 wherein said shape-retaining means comprises a foraminous sheet member.
Claim 4
Dependent Claim
17 words
A filter according to claim 2 wherein said foraminous sheet member is in contact with said gel.
Claim 5
Dependent Claim
14 words
A filter according to claim 3 wherein said foraminous sheet member comprises-a fibrous network.
Claim 6
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a woven fabric.
Claim 7
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a knitted fabric.
Claim 8
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a non-woven fabric.
Claim 9
Dependent Claim
19 words
A filter according to claim 2 wherein said shape-retaining means comprises a plurality of wires which intersect one another.
Claim 10
Dependent Claim
15 words
A filter according to claim 8 wherein said wires are in contact with said gel.
Claim 11
Dependent Claim
17 words
A filter according to claim 9 wherein said wires are in the form of a wire screen.
Claim 12
Dependent Claim
16 words
A filter according to claim 9 wherein said wires are in the form of-a wire mesh.
Claim 13
Dependent Claim
18 words
A filter according to claim 9 wherein said wires are in the form of an expanded wire sheet.
Claim 14
Dependent Claim
12 words
A filter according to claim 9 wherein said wires are metal wires.
Claim 15
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing silk.
Claim 16
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing nylon.
Claim 17
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing cellulose.
Claim 18
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing cotton.
Claim 19
Dependent Claim
17 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing a natural fiber.
Claim 20
Dependent Claim
18 words
A filter according to claim 4 wherein said fib rous network comprises a sheet containing a synthetic fiber.
Claim 21
Dependent Claim
21 words
A filter according to claim 1 wherein the aver effective age/pore size of said fibrin gel is 0,003 to 1,0 µm.
Claim 22
Dependent Claim
22 words
A filter according to claim 1 wherein the aver effective. age/pore size of said fibrin gel is 0,009 to 0 ,3 µm.
Claim 23
Dependent Claim
18 words
A filter according to claim 1 wherein said fibrin gel is formed by contacting fibrinogen with an enzyme.
Claim 24
Dependent Claim
13 words
A filter according to claim 22 wherein said enzyme is a coagulation enzyme.
Claim 25
Dependent Claim
27 words
A filter according to claim 23 wherein said coagulation enzyme is selected from the group consisting of thrombin, Batroxobin, Arvin, Eccarin, Papain, Staphylocoagulase, Trypsin, caterpiller venom enzyme.
Claim 26
Dependent Claim
25 words
A filter according to claim 23 wherein said fibrinogen is brought in contact with said enzyme in the presence of at least one calcium ion.
Claim 27
Dependent Claim
21 words
A filter according to claim 25 wherein the calcium ion concentration in the gel formation mixture is up to 20 mM.
Claim 28
Dependent Claim
23 words
A filter according to claim 23 wherein the enzyme is thrombin and the gel is prepared in the absence of a calcium ion.
Claim 29
Dependent Claim
11 words
A filter according to claim 25 wherein said enzyme is Batroxobin.
Claim 30
Dependent Claim
23 words
A filter according to claim 1 wherein said fibrin gel is a crosslinked fibrin gel and said shape-retaining means is a crosslinking agent.
Claim 31
Dependent Claim
22 words
A filter according to claim 29 wherein said crosslinking agent is selected from the group consisting of dialdehydes, azides, aromaticdihalides, and bis-imidates.
Claim 32
Dependent Claim
12 words
A filter according to claim 29 wherein said crosslinking agent is glutardialdehyde.
Claim 33
Dependent Claim
20 words
A filter according to claim 1 wherein said gel is crosslinked and said shape-retaining means comprises a foraminous sheet member..
Claim 34
Dependent Claim
16 words
-33. A filter according to claim 32 wherein said foraminous sheet member comprises a fibrous network.
Claim 35
Dependent Claim
21 words
-34. A filter according to claim 1 wherein said gel has disposed on at least its upper surface a shape-retaining means.
Claim 36
Dependent Claim
19 words
A filter according to claim 34 wherein said gel has disposed on its lower surface a second shape-retaining means.
Claim 37
Dependent Claim
15 words
A filter according to claim 35 wherein said second shape-retaining means comprises a forminous sheet.
Claim 38
Dependent Claim
16 words
A filter according to claim 1 wherein said gel is adhesively secured to said shape-retaining means.
Claim 39
Dependent Claim
15 words
A filter according to claim 1 wherein said gel is grafted to said shape-retaining means.
Claim 40
Dependent Claim
25 words
A filter according to claim 1 wherein said shape-retaining means is a foraminous member having'pores or openings of a size of 0.01 to 5 mm.
Claim 41
Dependent Claim
123 words
A process for separating a first substance of 0,003 to 1 having a size/pm from a second substance with which it is in admixture said second substance having a larger size than said first substance which comprises passing said mixture of said first substance and second substances over a filter comprising fibrin gel form having pores of substantially uniform size, said gel having pores of a size to permit passage therethrough of said first substance but excluding said second substance, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium, wherein tha effective pore size of said fibrin gel is larger than the particle size of said second substance.
Claim 42
Dependent Claim
123 words
A process for separating a first substance of 0,003 to 1 having a size/pm from a second substance with which it is in admixture said second substance having a larger size than said first substance which comprises passing said mixture of said first substance and second substances over a filter comprising fibrin gel form having pores of substantially uniform size, said gel having pores of a size to permit passage therethrough of said first substance but excluding said second substance, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium, wherein tha effective pore size of said fibrin gel is larger than the particle size of said second substance.
Claim 43
Dependent Claim
23 words
A process according to claim 40 wherein said gel has substantially uniform pore sizes in the range of 0,009 to 0, 3 µm.
Claim 44
Dependent Claim
25 words
A process according to claim 40 wherein at least one component of blood is separated from another component by passing said blood over said filter.
Claim 45
Dependent Claim
27 words
A process according to claim 40 wherein at least one component of blood plasma is removed from another component by passing said vlood plasma over said filter.
Claim 46
Dependent Claim
17 words
A process according to claim 43 wherein blood platelets are separated from blood plasma containing blood platelets.
Claim 47
Dependent Claim
27 words
A process according to claim 40 wherein at least one component of a mammalian liver is separated from another component by passing the mixture over said -filter.
Claim 48
Dependent Claim
14 words
A process according to claim 45 wherein mitochondia is separated from liver cell fragments.
Claim 49
Dependent Claim
19 words
A process according to claim 40 wherein a virus is separated from components within which it is in admixture.
Claim 50
Dependent Claim
11 words
A process according to claim 47 wherein said virus is Sendai-virus.
Claim 51
Dependent Claim
19 words
A process according to claim 40 wherein a bacterium is separated from components within which it is in admixture.
Claim 52
Dependent Claim
12 words
A process according to claim 49 wherein said bacterium is E. coli.
Claim 53
Dependent Claim
17 words
A process according to claim 22 wherein said gel is formed in the presence of Factor XIII.
References Cited (Backward Citations)
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