Diphosphonic acid derivatives and pharmaceutical preparations containing them

Abstract

Abstract 1. Diphosphonic acid derivatives of general formula 1 see diagramm : EP0084822,P8,F1 wherein R is hydrogen, an alkali metal, an alkaline earth metal or an alkyl group of 1 to 4 carbon atoms, and A is a group see diagramm : EP0084822,P8,F2 wherein X is hydrogen, methyl or ethyl, and B is phenyl substituted in the para position by an isobutyl, cyclohexyl, alkoxy or 1-pyrrolinyl group, and optionally substituted in the meta position by fluorine or chlorine, or is phenyl substituted in the meta position by benzoyl or a phenoxy group or is phenyl substituted in the ortho position by a 2,4-dichlorphenoxy or a 2,6-dichlorphenylamino group, or see diagramm : EP0084822,P8,F3 wherein R1 is a cyclohexyl or cyclopentylmethyl group and Y is hydrogen or chlorine, or see diagramm : EP0084822,P8,F4 wherein X has the meaning given above, and see diagramm : EP0084822,P9,F5 is the group see diagramm : EP0084822,P9,F6 wherein n is the integer 1,2 or 3, W and W' are the same or different and are hydrogen, chlorine or fluorine, and one of the groups V or V' is nitrogen and the other is a methyne group, optionally substituted by phenyl, or see diagramm : EP0084822,P9,F7 wherein R2 is a p-chlorobenzoyl or a cinnamoyl group.

Inventors

• 👤 Helmut Dr. Biere
• 👤 Clemens Dr. Rufer
• 👤 Irmgard Dr. Böttcher

Bibliographic Details