EP0080281A1
Expired / Lapsed
EP
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Therapeutic use of allantoin-formaldehyde condensation products
Assignee: Wigglesworth Ltd
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Filing: 1982-11-04
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Granted: —
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Expires: 2002-11-04
Abstract
Abstract Monomeric, dimeric and polymeric allantoinformal- dehyde condensation products, especially imidazolidinyl urea and diazolidinyl urea, have been found to be therapeutically effective in the treatment of humans and animals, especially in the treatment of diseases and malconditions of the skin and other membranes. The compounds have the advantages of water-solubility, low toxicity, low irritancy and broad action, which is a combination of properties not found in many drugs. The compounds may be used in a wide variety of compositions and formulations.
Inventors
- 👤 Anthony Ralph Harrison
- 👤 Alexander Mckenzie Morrison
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 13:32
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/88
Claims Analysis
Total Claims: 57
Claim 1
Independent Claim
150 words
A monomeric, dimeric or polymeric compound that is a condensation product of formaldehyde and allantoin in a molar proportion of 1 to at least 0.5, respectively, in which the monomeric compound or each monomeric unit is of the qeneral formula in which each R denotes H, -CH 2 0H or (-CH 2 -) ½ , with the provisos that (a) in a monomeric compound, R cannot denote (CH 2 ) ½ and at least one R denotes -CH 2 0H, (b) in each unit of a dimeric compound and in each terminal unit of a polymeric compound, at least one symbol R denotes (-CH 2 -) ½ , and (c) in each non-terminal unit of a polymeric compound, each of at least two symbols R denotes (-CH 2 -) ½ , or a physiologically tolerable salt of such a compound, for use in the therapeutic treatment of humans or animals.
Claim 2
Dependent Claim
150 words
A monomeric, dimeric or polymeric compound that is a condensation product of formaldehyde and allantoin in a molar proportion of 1 to at least 0.5, respectively, in which the monomeric compound or each monomeric unit is of the qeneral formula in which each R denotes H, -CH 2 0H or (-CH 2 -) ½ , with the provisos that (a) in a monomeric compound, R cannot denote (CH 2 ) ½ and at least one R denotes -CH 2 0H, (b) in each unit of a dimeric compound and in each terminal unit of a polymeric compound, at least one symbol R denotes (-CH 2 -) ½ , and (c) in each non-terminal unit of a polymeric compound, each of at least two symbols R denotes (-CH 2 -) ½ , or a physiologically tolerable salt of such a compound, for use in the therapeutic treatment of humans or animals.
Claim 3
Dependent Claim
21 words
Imidazolidinyl urea or diazolidinyl urea, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of humans or animals.
Claim 4
Dependent Claim
21 words
Imidazolidinyl urea or diazolidinyl urea, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of humans or animals.
Claim 5
Dependent Claim
40 words
A compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of diseases, malconditions and other disorders of the skin and other membranes of the human or animal body.
Claim 6
Dependent Claim
30 words
A compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of the intestines or uterus of an animal.
Claim 7
Dependent Claim
25 words
A compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of animal hooves.
Claim 8
Dependent Claim
31 words
A compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof, for use in the therapeutic treatment of the ears and eyes of humans or animals.
Claim 9
Dependent Claim
30 words
A compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof, for the therapeutic treatment of cattle udders for the prevention or cure of mastitis.
Claim 10
Dependent Claim
161 words
A composition which comprises a therapeutically effective amcunt of a monomeric, dimeric or polymeric compound that is a condensation product of formaldehyde and allantoin in a molar proportion of 1 to at least 0.5, respectively, in which the monomeric compound or each monomeric unit is of the general formula in which each R denotes H, -CH 2 OH or (-CH 2 -) ½ , with the provisos that (a) in a monomeric compound, R cannot denote (CH 2 -) ½ and at least one R denotes -CH 2 0H, (b) in each unit of a dimeric compound and in each terminal unit of a polymeric compound, at least one symbol R denotes (-CH 2 ) ½ , and (c) in each non-terminal unit of a polymeric compound, each of at least two symbols R denotes (- CH 2 -) 1/ 2, or a physiologically tolerable salt of such a compound, in admixture or conjunction with a pharmaceutically or veterinarily suitable carrier.
Claim 11
Dependent Claim
161 words
A composition which comprises a therapeutically effective amcunt of a monomeric, dimeric or polymeric compound that is a condensation product of formaldehyde and allantoin in a molar proportion of 1 to at least 0.5, respectively, in which the monomeric compound or each monomeric unit is of the general formula in which each R denotes H, -CH 2 OH or (-CH 2 -) ½ , with the provisos that (a) in a monomeric compound, R cannot denote (CH 2 -) ½ and at least one R denotes -CH 2 0H, (b) in each unit of a dimeric compound and in each terminal unit of a polymeric compound, at least one symbol R denotes (-CH 2 ) ½ , and (c) in each non-terminal unit of a polymeric compound, each of at least two symbols R denotes (- CH 2 -) 1/ 2, or a physiologically tolerable salt of such a compound, in admixture or conjunction with a pharmaceutically or veterinarily suitable carrier.
Claim 12
Dependent Claim
14 words
A composition as claimed in claim 8, wherein the said compound is imidazolidinyl urea.
Claim 13
Dependent Claim
14 words
A composition as claimed in claim 8, wherein the said compound is diazolidinyl urea.
Claim 14
Dependent Claim
20 words
A composition as claimed in any one of claims 8 to 10, formulated for external application to humans or animals.
Claim 15
Dependent Claim
20 words
A composition as claimed in any one of claims 8 to 10, formulated for internal application to humans or animals.
Claim 16
Dependent Claim
16 words
A composition as claimed in any one of claims 8 to 12, formulated in unit-dosage form.
Claim 17
Dependent Claim
85 words
A composition as claimed in any one of claims 8 to 10, formulated for internal application to humans or animals, and comprising the said compound or salt in an amount of at least 1% by weight, based on the total weight of the composition, wherein the carrier comprises one or more carriers selected from (a) a non-liquid carrier, optionally in conjunction with a liquid carrier, (b) a liquid carrier other than water, optionally in conjunction with water, and (c) water in conjunction with another substance.
Claim 18
Dependent Claim
17 words
A composition as claimed in claim 14, wherein the said amount is at least 1.5% by weight.
Claim 19
Dependent Claim
101 words
A composition as claimed in any one of claims 8 to 10, formulated for external application to humans or animals and not being a cosmetic composition, and comprising the said compound or salt in an amount of at least 1% by weight, based on the total weight of the composition, in admixture or conjunction with one or more carriers selected from (a) a non-liquid carrier, optionally in conjunction with a liquid carrier (b) a liquid carrier in conjunction with a propellant, (c) a liquid carrier other than water, optionally in conjunction with water, and (d) water in conjunction with another substance.
Claim 20
Dependent Claim
95 words
A composition as claimed in any one of claims 8 to 10, formulated for external application to humans or animals and comprising the said compound or salt in an amount of at least 1.5% by weight, based on the total weight of the composition, in admixture or conjunction with one or more carriers selected from (a) a non-liquid carrier, optionally in conjunction with a liquid carrier, (b) a liquid carrier in conjunction with a propellant, (c) a liquid carrier other than water, optionally in conjunction with water, and (d) water in conjunction with another substance.
Claim 21
Dependent Claim
22 words
A composition as claimed in any one of claims 15 to 17, wherein the said amount is at least 2% by weight.
Claim 22
Dependent Claim
22 words
A composition as claimed in any one of claims 15 to 18, wherein the said amount is at least 5% by weight.
Claim 23
Dependent Claim
20 words
A composition as claimed in any one of claims 8 to 19, wherein the carrier comprises physiologically tolerable saline solution.
Claim 24
Dependent Claim
29 words
A composition as claimed in any one of claims 8 to 10, in the form of a bolus, capsule, pill, tablet or the like for oral administration to animals.
Claim 25
Dependent Claim
45 words
A composition as claimed in claim 21, wherein the said compound or salt is present in an amount within the range of from 2.5 to 15% by weight, based on the total weight of the composition (excluding, in the case of a capsule, the shell).
Claim 26
Dependent Claim
37 words
A composition as claimed in any one of claims 8 to 10, in a form suitable for uterine infusion in animals and comprising the said compound or salt in admixture or conjunction with physiologically tolerable saline solution.
Claim 27
Dependent Claim
36 words
A composition as claimed in claim 23, wherein the said compound or salt is present in an amount within the range of from 2 to 10% by weight, based on the total weight of the composition.
Claim 28
Dependent Claim
41 words
A composition as claimed in any one of claims 8 to 10, in a form suitable for external application to humans or animals by spraying, and comprising the said compound or salt in admixture or conjunction with physiologically tolerable saline solution.
Claim 29
Dependent Claim
36 words
A composition as claimed in claim 25, wherein the said compound or salt is present in an amount within the range of from 1 to 10% by weight, based on the total weight of the composition.
Claim 30
Dependent Claim
51 words
A composition as claimed in any one of claims 8 to 10, in a form suitable for external application to humans or animals by spraying, and comprising the said compound or salt in admixture or conjunction with a film-forming agent (other than the said compound and allantoin) and a volatile diluent.
Claim 31
Dependent Claim
36 words
A composition as claimed in claim 27, wherein the said compound or salt is present in an amount within the range of from 5 to 30% by weight, based on the total weight of the composition.
Claim 32
Dependent Claim
26 words
A composition as claimed in any one of claims 8 to 10, in the form of a gel or the like for intramammary administration to cattle.
Claim 33
Dependent Claim
36 words
A composition as claimed in claim 29, wherein the said compound or salt is present in an amount within the range of from 1 to 10% by weight, based on the total weight of the composition.
Claim 34
Dependent Claim
55 words
A composition as claimed in any one of claims 8 to lO, in the form of a gel, jelly, cream, ointment, wax, or the like suitable for extramammary application to cattle and comprising the said compound or salt in an amount of at least 5% by weight, based on the total weight of the composition.
Claim 35
Dependent Claim
36 words
A composition as claimed in claim 31, wherein the said compound or salt is present in an amount within the range of from 5 to 10% by weight, based on the total weight of the composition.
Claim 36
Dependent Claim
18 words
A composition as claimed in any one of claims 8 to 10, in the form of an ointment.
Claim 37
Dependent Claim
22 words
A composition as claimed in claim 33, wherein the ointment is suitable for application to eyes or ears of humans or animals.
Claim 38
Dependent Claim
39 words
A composition as claimed in claim 33 or claim 34, wherein the said compound or salt is present in an amount within the range of from 1 to 10% by weight, based on the total weight of the composition.
Claim 39
Dependent Claim
56 words
A composition as claimed in any one of claims 8 to 10, in a form suitable for external application to humans or animals, wherein the composition comprises the said compound or salt in an amount of more than 1% by weight, based on the total weight of the composition, and additionally comprises a topical anaesthetic agent.
Claim 40
Dependent Claim
19 words
A composition as claimed in claim 36, in the form of a gel, jelly, cream, ointment or the like.
Claim 41
Dependent Claim
39 words
A composition as claimed in claim 36 or claim 37, wherein the said compound or salt is present in an amount within the range of from 1 to 20% by weight, based on the total weight of the composition.
Claim 42
Dependent Claim
54 words
A composition as claimed in any one of claims 8 to 10, in the form of a gel, jelly, cream, ointment or the like and not being a cosmetic composition, and comprising the said compound or salt in an amount of at least 1% by weight, based on the total weight of the composition.
Claim 43
Dependent Claim
48 words
A composition as claimed in any one of claims 8 to 10, in the form of a gel, jelly, cream, ointment or the like and comprising the said compound or salt in an amount of at least 1.5% by weight, based on the total weight of the composition.
Claim 44
Dependent Claim
28 words
A composition as claimed in claim 39 or claim 40, wherein the said amount is at least 2% by weight, based on the total weight of the composition.
Claim 45
Dependent Claim
28 words
A composition as claimed in claim 39 or claim 40, wherein the said amount is at least 5% by weight, based on the total weight of the composition.
Claim 46
Dependent Claim
39 words
A composition as claimed in any one of claims 8 to 10, in the form of a mouthwash, wherein the composition additionally comprises one or more auxiliaries selected from a sweetening agent, a flavouring agent, and a colouring agent.
Claim 47
Dependent Claim
36 words
A composition as claimed in claim 43, wherein the said compound or salt is present in an amount within the range of from 2 to 15% by weight, based on the total weight of the composition.
Claim 48
Dependent Claim
43 words
A composition as claimed in any one of claims 8 to 10, in a form suitable for external application to humans and animals, wherein the composition comprises at least 10% by weight of an alcohol, based on the total weight of the composition.
Claim 49
Dependent Claim
36 words
A composition as claimed in claim 45, wherein the said compound or salt is present in an amount within the range of from 1 to 10% by weight based on the total weight of the composition.
Claim 50
Dependent Claim
28 words
A surgical dressing, surgical swab or the like that is impregnated with a compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof.
Claim 51
Dependent Claim
35 words
A process for the treatment of a surgical dressing, surgical swab or the like which comprises applying to it a compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof.
Claim 52
Dependent Claim
21 words
A process as claimed in claim 48, wherein the said compound or salt is applied in the form of a powder.
Claim 53
Dependent Claim
21 words
A process as claimed in claim 48, wherein the said compound or salt is applied in the form of a solution.
Claim 54
Dependent Claim
27 words
A process as claimed in any one of claims 48 to 50, wherein the dressing, swab or the like is impregnated with the said compound or salt.
Claim 55
Dependent Claim
33 words
A process for the treatment of a contact lens, which comprises treating it with a solution of a compound as defined in claim 1 or claim 2, or a physiologically tolerable salt thereof.
Claim 56
Dependent Claim
14 words
A composition substantially as described in any one of Examples 1 to 12 herein.
Claim 57
Dependent Claim
14 words
A composition substantially as described in any one of Examples 1 to 12 herein.
References Cited (Backward Citations)
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