EP0076621A2
Expired / Lapsed
EP
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Azetidinone derivatives
Assignee: Ajinomoto Co Inc
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Filing: 1982-09-29
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Granted: —
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Expires: 2002-09-29
Abstract
Abstract Azetidinone derivatives having the general formula: <CHEM> wherein Z is methylthio group or a methylsulphonyl group, X is a hydrogen atom, a halogen atom, an amino group, an alkylamino group or an acylamino group, and Y is either of the groups: <CHEM> wherein R is an alkyl group, an aralkyl group or a 2,2,2-trichloroethyl group, and M is a halogen atom or an alkali metal atom, are useful for inhibiting the activity of beta -lactamase such as that produced by bacteria being treated with a penicillin or a cephalosporin.
Inventors
- 👤 Toshihisa Kato
- 👤 Hisao Iwagami
- 👤 Naohiko Yasuda
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 10:51
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/12; A; A61; A61P; A61P31/00; A61P31/04; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D205/09; C07D205/095
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
60 words
An azetidinone derivative having the general formula: wherein n is O or 2, X is a hydrogen atom, a halogen atom, an amino group or a substituted amino group, and Y is either of the groups: wherein R is an alkyl group, an aralkyl group or a 2,2,2-trichloroethyl group, and M is a halogen atom or an alkali metal atom.
Claim 2
Dependent Claim
60 words
An azetidinone derivative having the general formula: wherein n is O or 2, X is a hydrogen atom, a halogen atom, an amino group or a substituted amino group, and Y is either of the groups: wherein R is an alkyl group, an aralkyl group or a 2,2,2-trichloroethyl group, and M is a halogen atom or an alkali metal atom.
Claim 3
Dependent Claim
1 words
1-(1-Benzyloxycarbonyl-1-methoxycarbonylmethyl)-4-methylthio-2-azetidinone.
Claim 4
Dependent Claim
1 words
1-(1-Benzyloxycarbonyl-1-methoxycarbonylmethyl)-4-methylthio-2-azetidinone.
Claim 5
Dependent Claim
1 words
1-(1-Carboxyl-1-methyloxycarbonyl-methyl)-4-methylthio-2-azetidinone.
Claim 6
Dependent Claim
1 words
1-(1-Carboxyl-1-methyloxycarbonyl-methyl)-4-methylthio-2-azetidinone.
Claim 7
Dependent Claim
1 words
1-(1-Benzyloxycarbonyl-1-methoxycarbonylmethyl)-4-methylsulfonyl-2-azetidinone.
Claim 8
Dependent Claim
1 words
1-(1-Benzyloxycarbonyl-1-methoxycarbonylmethyl)-4-methylsulfonyl-2-azetidinone.
Claim 9
Dependent Claim
1 words
1-(1-Carboxy-1-methoxycarbonyl-methyl)-4-methylsulfonyl-2-azetidinone.
Claim 10
Dependent Claim
1 words
1-(1-Carboxy-1-methoxycarbonyl-methyl)-4-methylsulfonyl-2-azetidinone.
Claim 11
Dependent Claim
2 words
(3R,4R)-1-(1-carboxy-2-methylpropen-1-yl)-4-methylsulfonyl-3-[D(-)-α-aminophenylacetamido]-2- azetidinone.
Claim 12
Dependent Claim
2 words
(3R,4R)-1-(1-carboxy-2-methylpropen-1-yl)-4-methylsulfonyl-3-[D(-)-α-aminophenylacetamido]-2- azetidinone.
Claim 13
Dependent Claim
1 words
(3R,4R)-1-(1-carboxy-2-methylpropen-1-yl)-4-methylsulfonyl-3-amino-2-azetidinone.
Claim 14
Dependent Claim
1 words
(3R,4R)-1-(1-carboxy-2-methylpropen-1-yl)-4-methylsulfonyl-3-amino-2-azetidinone.
Claim 15
Dependent Claim
2 words
(3R,4R)-1-(1-carboxyl-2-methylpropen-1-yl)-4-methylsulfonyl-3-[D(-)1-α-(4-ethyl-2,3-dioxo-1-piperazine-carboxamide)-C(-(4-hydroxyphenyl) acetamide]-2-azetidinone.
Claim 16
Dependent Claim
2 words
(3R,4R)-1-(1-carboxyl-2-methylpropen-1-yl)-4-methylsulfonyl-3-[D(-)1-α-(4-ethyl-2,3-dioxo-1-piperazine-carboxamide)-C(-(4-hydroxyphenyl) acetamide]-2-azetidinone.
Claim 17
Dependent Claim
22 words
The use of an azetidinone derivative as claimed in any of claims 1 to 8 for inhibiting the activity of β -lactamase.
References Cited (Backward Citations)
No citation records indexed.
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