Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
98 words
A compound having the formula: wherein X is -CH 2 -CH 2 , -CH=CH-, or is methyl, ethyl, isopropyl or sec-butyl; R 2 is hydrogen, methyl, acetyl, phenoxyacetyl or tert-butyl dimethylsilyl; R 3 is hydrogen, hydroxy, acetoxy, a-L-oleandrosyloxy, 4'-acetyl-a-L-oleandrosyloxy, 4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy, 4"-acetyl-4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy, or 4"-(phenoxyacetyl)-4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy; and R 4 is hydrogen, acetyl, benzoyl, pyridinylcarbonyl, or pyrrollylcarbonyl. -CO(CH 2 ) n COOH, or -CO(CH 2 ) n COOM, wherein n is 2, 3 or 4 and M is an alkali metal or an ammonium or diloweralkyl ammonium cation; provided that R 4 is pyrrollylcarbonyl only when R l is isopropyl or sec-butyl.
Claim 2
Dependent Claim
98 words
A compound having the formula: wherein X is -CH 2 -CH 2 , -CH=CH-, or is methyl, ethyl, isopropyl or sec-butyl; R 2 is hydrogen, methyl, acetyl, phenoxyacetyl or tert-butyl dimethylsilyl; R 3 is hydrogen, hydroxy, acetoxy, a-L-oleandrosyloxy, 4'-acetyl-a-L-oleandrosyloxy, 4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy, 4"-acetyl-4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy, or 4"-(phenoxyacetyl)-4'-(a-L-oleandrosyl)-a-L-oleandrosyloxy; and R 4 is hydrogen, acetyl, benzoyl, pyridinylcarbonyl, or pyrrollylcarbonyl. -CO(CH 2 ) n COOH, or -CO(CH 2 ) n COOM, wherein n is 2, 3 or 4 and M is an alkali metal or an ammonium or diloweralkyl ammonium cation; provided that R 4 is pyrrollylcarbonyl only when R l is isopropyl or sec-butyl.
Claim 3
Dependent Claim
11 words
The compound of Claim 1 wherein X is -CH=C H -.
Claim 4
Dependent Claim
9 words
The compound of Claim 2 which is 4a-hydroxy-avermectin Bla/Blb.
Claim 5
Dependent Claim
13 words
The compound of Claim 1 wherein X is -CH 2 -CH 2 -.
Claim 6
Dependent Claim
10 words
The compound of Claim 4 which is 4a-hydroxy-22,23-dihydro avermectin Bla/Blb.
Claim 7
Dependent Claim
10 words
The compound of Claim 4 which is 4a[(2-pyrrollylcarbonyl)oxy]-22,23-dihydro avermectin Bla/Blb.
Claim 8
Dependent Claim
10 words
The compound of Claim 1 wherein R 3 is hydrogen.
Claim 9
Dependent Claim
95 words
A method for the preparation of a compound as claimed in Claim 1, that comprises oxidizing, with t-butyl hydroperoxide and a catalytic amount of selenium dioxide, a compound having the formula where R 1 , R 2 , R 3 and X are as defined in Claim 1, to produce a compound as claimed in Claim 1 in which R 4 is hydrogen; and, if a compound in which R 4 is other than hydrogen is desired, acylating the said compound in which R 4 is hydrogen with a compound of formula R 4 -H.
Claim 10
Dependent Claim
29 words
A compound as claimed in any one of Claims 1 to 7 for use in the treatment of parasitic infections by being administered to an animal infected with parasites.
Claim 11
Dependent Claim
27 words
A composition useful for treating animals infected with parasites which comprises an inert carrier and a compound as claimed in any one of Claims 1 to 7.