EP0074584A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Prolonged-action multiple-layer tablets
Assignee: Chugai Pharmaceutical Co Ltd
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Filing: 1982-09-03
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Granted: —
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Expires: 2002-09-03
Abstract
Abstract A prolonged-action multiple-layer tablet having an increased rate of dissolution of the active ingredient from a given point of time onward is disclosed. The table comprises layer A made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator and a binder, and layer B made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator, a binder and the active ingredient. In the tablet, a quick-release layer containing the active ingredient may be formed on either layer A or B.
Inventors
- 👤 Yoshimitsu Iida
- 👤 Atsuko Yoshizawa
- 👤 Tatuo Kujirai
- 👤 Toshichika Ogasawara
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 16:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
94 words
A prolonged-action multiple-layer tablet having an increased rate of dissolution of the active ingredient from a given point of time onward comprising layer A made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator and a binder, and layer B made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator, a binder and the active ingredient.
Claim 2
Dependent Claim
94 words
A prolonged-action multiple-layer tablet having an increased rate of dissolution of the active ingredient from a given point of time onward comprising layer A made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator and a binder, and layer B made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 µm or less and which is solid at ordinary temperatures, a disintegrator, a binder and the active ingredient.
Claim 3
Dependent Claim
22 words
A tablet according to Claim 1 wherein a quick-release layer containing the active ingredient is formed on either layer A or B.
Claim 4
Dependent Claim
25 words
A tablet according to Claim 1 wherein the water-insoluble wax which is solid at ordinary temperatures has an average size of 5 pm or less.
Claim 5
Dependent Claim
40 words
A tablet according to Claim 1 wherein the water-insoluble wax which is solid at ordinary temperatures is selected from among hydrogenated castor oil, hydrogenated soybean oil, carnauba wax, paraffin, palmitic acid, stearic acid, bees wax, stearyl alcohol, and octadecyl alcohol.
Claim 6
Dependent Claim
32 words
A tablet according to Claim 1 wherein the disintegrator is selected from among low-substituted hydroxypropyl cellulose, carboxymethyl cellulose, calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, corn starch, sodium starch glycolate and hydroxypropyl starch.
Claim 7
Dependent Claim
20 words
A tablet according to Claim 1 wherein the disintegrator is contained in an amount of from 0.5 to 40% (w/w).
Claim 8
Dependent Claim
20 words
A tablet according to Claim 1 wherein the disintegrator is contained in an amount of from 1 to 20% (w/w).
Claim 9
Dependent Claim
27 words
A tablet according to Claim 1 wherein the binder is selected from among hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxypropylmethyl cellulose phthalate, gelatin, a-starch, polyvinyl pyrrolidone and polyethylene glycol.
Claim 10
Dependent Claim
20 words
A tablet according to Claim 1 wherein the binder is contained in an amount of from 0.1 to 30% (w/w).
Claim 11
Dependent Claim
20 words
A tablet according to Claim 1 wherein the binder is contained in an amount of from 0.5 to 15% (w/w).
Claim 12
Dependent Claim
27 words
A tablet according to Claim 1 wherein the active ingredient is selected from among a nitrate ester of N-(2-hydroxyethyl)nicotinic acid amide, acetyl salicylic acid and ethyl 7-(4-(2-methoxyphenyl)-1-piperazino]heptanoate.
References Cited (Backward Citations)
No citation records indexed.
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