EP0068563A2
Expired / Lapsed
EP
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Heterocyclic acetic acid compounds and compositions for treating bone diseases
Assignee: Procter and Gamble Co
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Filing: 1982-06-16
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Granted: —
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Expires: 2002-06-16
Abstract
Abstract Certain acetic acid derivatives of benzothiophene, benzimidazole, phenothiazine, benzofuran, dibenzothiophene. and similar heterocyclic compounds have been found to inhibit bone resorption and to enhance bone formation. The compounds of this invention are therefore useful in the treatment of diseases characterized by anomalous bone metabolism.
Inventors
- 👤 Mahdi Bakir Fawzi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:52
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; A; A61; A61P; A61P43/00; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D235/16; C07D333/00; C07D333/50; C07D333/52; C07D333/54; C07D333/60; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4025; C07F9/405; C07F9/547; C07F9/6553; C07F9/655345; C07F9/655354
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
84 words
Compounds characterized in that they have the formula: or wherein R 1 is - CHR 2 COOH, and salts and esters thereof; R 2 is hydrogen, alkyl, alkoxy, - OH, -Cl, - F, - NH 2 , - COOH, - PO(OH) 2 , or - SO 2 OH, and esters and salts thereof, X' is N, CH, COH, or COCH 3 ; X" is NH, S, 0, CH 2 , CHOH, CHOCH 3 , or C = 0; Y is NH, S, or 0.
Claim 2
Dependent Claim
84 words
Compounds characterized in that they have the formula: or wherein R 1 is - CHR 2 COOH, and salts and esters thereof; R 2 is hydrogen, alkyl, alkoxy, - OH, -Cl, - F, - NH 2 , - COOH, - PO(OH) 2 , or - SO 2 OH, and esters and salts thereof, X' is N, CH, COH, or COCH 3 ; X" is NH, S, 0, CH 2 , CHOH, CHOCH 3 , or C = 0; Y is NH, S, or 0.
Claim 3
Dependent Claim
15 words
The compounds of Claim 1 characterized in that R 1 is - CH 2 COOH.
Claim 4
Dependent Claim
14 words
The compounds of Claim 1 or 2 characterized in that R 2 is hydrogen.
Claim 5
Dependent Claim
25 words
The compounds of any one of Claims 1-3 characterized in that X' is N or CH, and X" is NH, S or CH 2 .
Claim 6
Dependent Claim
10 words
The compound characterized in that it has the formula: .
Claim 7
Dependent Claim
10 words
The compound characterized in that it has the formula: .
Claim 8
Dependent Claim
9 words
The compound characterized in that it has the formula:
Claim 9
Dependent Claim
9 words
The compound characterized in that it has the formula:
Claim 10
Dependent Claim
117 words
A pharmaceutical composition in unit dosage form useful in treating diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of a compound of the formula: or wherein R 1 is - CHR 2 COOH, and salts and esters thereof; R 2 is hydrogen, alkyl, alkoxy, - OH, - Cl, - F, - NH 2 , - COOH, - PO(OH) 2 , or - SO 2 OH, and esters and salts thereof; X' is N, CH, COH, or COCH 3 , X" is NH, S, 0, CH 2 , CHOH, CHOCH 3 , or C = 0; Y is NH, S, or 0; or mixtures of such compounds.
Claim 11
Dependent Claim
117 words
A pharmaceutical composition in unit dosage form useful in treating diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of a compound of the formula: or wherein R 1 is - CHR 2 COOH, and salts and esters thereof; R 2 is hydrogen, alkyl, alkoxy, - OH, - Cl, - F, - NH 2 , - COOH, - PO(OH) 2 , or - SO 2 OH, and esters and salts thereof; X' is N, CH, COH, or COCH 3 , X" is NH, S, 0, CH 2 , CHOH, CHOCH 3 , or C = 0; Y is NH, S, or 0; or mixtures of such compounds.
Claim 12
Dependent Claim
21 words
The composition of Claim 7 characterized in that R 1 is - CH 2 COOH or a salt or ester thereof.
Claim 13
Dependent Claim
14 words
The composition of Claim 7 or 8, characterized in that R 2 is hydrogen.
Claim 14
Dependent Claim
25 words
The composition of any one of Claims 7-9 characterized in that X' is N or CH and X" is NH, S or CH 2 .
Claim 15
Dependent Claim
35 words
A pharmaceutical composition in unit dosage form useful in treating diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of the compound of the formula:
Claim 16
Dependent Claim
35 words
A pharmaceutical composition in unit dosage form useful in treating diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of the compound of the formula:
Claim 17
Dependent Claim
36 words
A pharmaceutical composition in unit dosage form useful in treating bone diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of the compound of the formula:
Claim 18
Dependent Claim
36 words
A pharmaceutical composition in unit dosage form useful in treating bone diseases characterized by abnormal bone metabolism, said composition being characterized in that it comprises a safe and effective amount of the compound of the formula:
References Cited (Backward Citations)
No citation records indexed.
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