Antifungal compositions with a high release rate of the drug as an elastic liquid dressing

Abstract

Abstract 1. Claims for the contracting states : BE, CH, LI, DE, FR, GB, IT, NL, SE Antimycotic agents which have relatively good release of active compounds and contain azole derivatives and customary formulation auxiliaries, characterised in that they contain 2-10% by weight of a spreading agent from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, caprylates/caproates of saturated fatty alcohols having the chain length of C12 to C18 , wax-like fatty acid esters, such as synthesized duck uropygial gland fat, silicone oils, isopropyl myristate/isorpopyl palmitate/isopropyl stearate mixture, coconut fatty acid isopropyl ester, 1-8% by weight of a solubilising agent and, as a film-forming agent, a quick-drying polyvinylpyrrolidone, a terpolymer of 30% by weight of vinylpyrrolidone, 40% by weight of vinyl acetate and 30% by weight of vinyl propionate, or a vinylpyrrolidone/vinyl acetate copolymer. 1. Claims for the contracting state : AT Process for the production of antimycotics based on azole derivative active compounds and costumary formulation auxiliaries, characterised in that the active compounds and the formulation auxiliaries are formulated together with 2 to 10% by weight of isopropyl myristate, isopropylpalmitate, isopropyl stearate, caprylates/caproates of saturated fatty alcohols having the chain length of C12 to C18 , waxy fatty acid esters, such as synthesized duck uropygial gland fat, silicone oils, isopropyl myristate/isopropyl palmitate/isopropyl stearate mixture or cocount fatty acid isopropylester as spreading agents, 1 to 8% by weight of solubilising agents, based in each case on the total weight, and a quick drying polyvinylpyrrolidone, a terpolymer of vinylpyrrolidone/vinyl acetate/vinyl propionate in a ratio by weight of 30:40:30, or a vinylpyrrolidone/vinylacetate copolymer as the film-forming agent.

Inventors

• 👤 Miklos Von Bittera
• 👤 Karl Heinz Prof. Dr. Büchel
• 👤 Manfred Dr. Plempel
• 👤 Erik Ing. Grad. Regel

Bibliographic Details