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EP0055048A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Polymers, preparation and use

Assignee: Smith and Nephew PLC
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Filing: 1981-12-07
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Granted: —
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Expires: 2001-12-07
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Abstract

Abstract Polymers containing 55 to 90% of units of the formula (A) : wherein R 1 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; and 10 to 45% of units of the formula (B) and (C): wherein R 2 is a hydrogen group of 5 to 19 carbon atoms, for example n-C 11 H 23 , R 3 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, R 4 is a hydrocarbon group of 5 to 19 carbon atoms, for example n-C 11 H 23 and X - is an anion and which contain at least 10% of units of formula (C) and are free from polymeric species having a molecular weight of less than 10,000 are described. The polymers possess antimicrobial activity against common pathogens. Isotonic aqueous solutions containing 0.002 to 0 . 0 25% of the polymer are suitable for the sterilisation of contact lenses for example by immersion of the lens in the solution overnight. Hydrophilic ointments containing from 0.002 to 0.25% of the polymer are suitable for the treatment of bacterial infection of lesions of the skin such as burns and ulcers.

Inventors

  • 👤 John Gordon Bernard Howes

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-27 05:28
CPC Classifications
A; A01; A01N; A01N43/00; A01N43/34; A01N43/36; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/143; A61L12/145; A61P; A61P31/00; A61P31/04; C; C08; C08G; C08G73/00; C08G73/02; C08G73/0273; C08G73/06; C08G73/0605; C08G73/0611

Claims Analysis

Total Claims: 14
Claim 1
Independent Claim 89 words
A polymer consisting essentially of 55 to 90% of units of the formula (A): wherein R 1 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; 10 to 45% of units of the formulae (B) and (C): wherein R 2 is a hydrocarbon group of 5 to 19 carbon atoms, R 3 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, R 4 is a hydrocarbon group of 5 to 19 carbon atoms and X - is an anion.
Claim 2
Dependent Claim 89 words
A polymer consisting essentially of 55 to 90% of units of the formula (A): wherein R 1 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; 10 to 45% of units of the formulae (B) and (C): wherein R 2 is a hydrocarbon group of 5 to 19 carbon atoms, R 3 is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, R 4 is a hydrocarbon group of 5 to 19 carbon atoms and X - is an anion.
Claim 3
Dependent Claim 35 words
A polymer as claimed in claim 1 wherein both R 1 and R are a hydrogen atom and both R 2 and R 4 are an n-alkyl group containing from 7 to 13 carbon atoms.
Claim 4
Dependent Claim 28 words
A polymer as claimed in either of claims 1 or 2 in which both R 2 and R 4 are an n-alkyl group which contains 11 carbon atoms.
Claim 5
Dependent Claim 19 words
A polymer as claimed in any of claims 1 to 3 in which X - is a chloride ion.
Claim 6
Dependent Claim 22 words
A polymer as claimed in any of claims 1 to 4 which has a weight average molecular weight of greater than 10,000.
Claim 7
Dependent Claim 41 words
A polymer as claimed in any of claims 1 to 5 which contains 60 to 80% of units of the formula (A), up to 22% of units of the formula (B) and 10 to 35% of units of the formula (C).
Claim 8
Dependent Claim 40 words
A polymer as claimed in any of claims 1 to 6 which contains 62 to 70% of units of formula (A), 15 to 20% of units of the formula (B) and 15 to 30% of units of the formula (C).
Claim 9
Dependent Claim 28 words
A pharmaceutical composition which contains an antimicrobially effective amount of a polymer as claimed in any of claims 1 to 7 together with a pharmaceutically acceptable carrier therefor.
Claim 10
Dependent Claim 31 words
A pharmaceutical composition as claimed in claim 8 which comprises a sterile aqueous solution containing from 0.001 to 0.5% of a polymer as claimed in any of claims 1 to 7.
Claim 11
Dependent Claim 46 words
A pharmaceutical composition as claimed in claim 8 which comprises a sterile, substantially isotonic aqueous solution suitable for the sterilisation of contact lenses containing from 0.002 to 0.025% of a polymer as claimed in any of claims 1 to 7 and a non-ionic tonicity adjusting agent.
Claim 12
Dependent Claim 30 words
A pharmaceutical composition as claimed in claim 8 which comprises a sterile ointment containing from 0.002 to 0.25% of a polymer as claimed in any of claims 1 to 7.
Claim 13
Independent Claim 46 words
A method for the sterilisation of contact lenses which comprises contacting said lens with a sterile substantially isotonic aqueous solution containing from 0.002 to 0.025% of a polymer as claimed in any of claims 1 to 7 for sufficient time for the sterilisation to be complete.
Claim 14
Dependent Claim 56 words
A pharmaceutical composition as claimed in claim 8 which comprises a sterile, substantially isotonic aqueous solution suitable for the wetting and sterilisation of contact lenses containing 0.002 to 0.025% of a polymer as claimed in any of claims 1 to 7, 0.01 to 2.5% of a non-ionic surface active agent and a non-ionic tonicity adjusting agent.

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