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EP0052004A1
Expired / Lapsed
EP
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System and method for controlling and monitoring blood or biologic fluid flow
Assignee: Purdue Research Foundation
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Filing: 1981-11-09
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Granted: —
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Expires: 2001-11-09
Abstract
Abstract A system and method are disclosed for controlling blood flow or flow of biologic fluid in an artificial organ or extracorporeal blood circuit. Selected parameters relating to blood flow are sensed and used to automatically optimize blood flow while assuring proper and safe operation. Utilized in conjunction with a reciprocating dialyzer apparatus (21), the system controls blood flow into and out of the dialyzer apparatus by controlling pressure on a slurry around the dialyzer membrane package. Slurry pressure is controlled by an actuator (16), such as a bellows pump, the pumping action of which is controlled by an electric motor (21), which motor, in turn, is electrically controlled by a control unit (29) which receives sensed indicators of blood flow, pressure and/or motor current. Blood contamination is also monitored for assuring safe operation of the dialyzer apparatus.
Inventors
- 👤 Stephen Richard Ash
- 👤 Benny Max Hillberry
- 👤 Randall Keith Roberts
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 09:20
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/14; A61M1/16; A61M1/26; A61M1/267; A61M1/30; A61M1/301; A61M1/304; A61M1/3403; A61M1/341; A61M1/342; A61M1/3424; A61M1/3427; A61M1/3472; A61M1/3486; A61M1/36; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/3334
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
118 words
A system for controlling biologic fluid flow, which comprises: fluid flow effecting means for causing fluid flow in a predetermined path; first monitoring means for monitoring fluid flow in the predetermined path and providing an output indicative of at least one preselected parameter thereof; second monitoring means connected with the fluid flow effecting means and providing an output indicative of at least one preselected parameter thereof; and processing means connected with the first and second monitoring means and the fluid flow effecting means to receive the outputs from the first and second monitoring means, and, at least partially responsive thereto, providing an output to the fluid flow effecting means to automatically control fluid flow in the predetermined path.
Claim 2
Independent Claim
118 words
A system for controlling biologic fluid flow, which comprises: fluid flow effecting means for causing fluid flow in a predetermined path; first monitoring means for monitoring fluid flow in the predetermined path and providing an output indicative of at least one preselected parameter thereof; second monitoring means connected with the fluid flow effecting means and providing an output indicative of at least one preselected parameter thereof; and processing means connected with the first and second monitoring means and the fluid flow effecting means to receive the outputs from the first and second monitoring means, and, at least partially responsive thereto, providing an output to the fluid flow effecting means to automatically control fluid flow in the predetermined path.
Claim 3
Dependent Claim
48 words
The system of Claim 1 wherein the fluid flow effecting means includes pressure means for varying the pressure exerted on the fluid to cause the fluid flow, and pressure control means for controlling the pressure means with the pressure control means receiving the output from the processing means.
Claim 4
Dependent Claim
26 words
The system of Claim 2 wherein the pressure control means includes a motor and motor control means connected to receive the output from the processing means.
Claim 5
Dependent Claim
27 words
The control system of Claim 3 wherein the second monitoring means includes means for sensing motor current and providing an output indicative thereof to the processing means.
Claim 6
Dependent Claim
39 words
The system of Claim 2 wherein the pressure means includes a sealed case having the fluid in one portion thereof, and a pressure actuator connected with the sealed case to establish pressure on the fluid within the sealed case.
Claim 7
Dependent Claim
30 words
The system of Claim 5 wherein the second monitoring means includes pressure sensing means for sensing the pressure within the sealed case and providing an electrical output signal indicative thereof.
Claim 8
Dependent Claim
42 words
The system of Claim 5 wherein the sealed case has at least one deformable membrane, and wherein the pressure actuator introduces a fluid under pressure into the sealed case at the other side of the membrane to control deforming of the membrane.
Claim 9
Dependent Claim
74 words
The system of Claim 1 wherein at least one of the first and second monitoring means provides an output indicative of improper operation with respect to fluid flow and provides an output indicative thereof to the processing means, and wherein the processing means, responsive to receipt of the output indicative of improper operation, provides an output to the fluid flow effecting means to cause termination of fluid flow or correction of the improper operation.
Claim 10
Independent Claim
119 words
A system for controlling biologic fluid flow in a reciprocating dialyzer apparatus wherein fluid flow into and out of the apparatus is through a single conduit, which comprises: fluid flow effecting means for causing fluid flow in reciprocal directions through the single conduit of the reciprocating dialyzer apparatus; monitoring means connected with the fluid flow effecting means and providing an output indicative of at least one preselected parameter thereof; and processing means connected with the monitoring means and the fluid flow effecting means to receive the outputs therefrom and, at least partially responsive thereto, providing an output to the fluid flow effecting means to automatically control fluid flow through the single conduit in reciprocal directions in a predetermined pattern.
Claim 11
Independent Claim
119 words
A system for controlling biologic fluid flow in a reciprocating dialyzer apparatus wherein fluid flow into and out of the apparatus is through a single conduit, which comprises: fluid flow effecting means for causing fluid flow in reciprocal directions through the single conduit of the reciprocating dialyzer apparatus; monitoring means connected with the fluid flow effecting means and providing an output indicative of at least one preselected parameter thereof; and processing means connected with the monitoring means and the fluid flow effecting means to receive the outputs therefrom and, at least partially responsive thereto, providing an output to the fluid flow effecting means to automatically control fluid flow through the single conduit in reciprocal directions in a predetermined pattern.
Claim 12
Dependent Claim
56 words
The system of Claim 9 wherein the fluid flow effecting means includes pressure means for varying the pressure exerted on the fluid to cause the fluid flow through the single conduit in the reciprocal directions, and pressure control means for controlling the pressure means with the pressure control means receiving the output from the processing means.
Claim 13
Dependent Claim
21 words
The system of Claim 10 wherein the monitoring means includes pressuring monitoring means for monitoring the pressure exerted on the fluid.
Claim 14
Independent Claim
162 words
A system for controlling blood flow in a reciprocating dialyzer apparatus, which comprises: means defining a blood chamber having a pressure responsive variable volume; pressure means connected with the blood chamber defining means for establishing the volume of the blood chamber; conduit means communicating with the blood chamber for blood flow therethrough to and from the blood chamber due to a change in volume of the blood chamber; first and second monitoring means for monitoring the rate of flow through the conduit means and for monitoring pressures exerted by the pressure means, and providing electrical signal outputs indicative thereof; programming means for receiving the electrical signal outputs from the monitoring means and establishing a program to effect cycling of blood flow through the conduit means to and from the blood chamber, the programming means providing a control signal output; and control means receiving the control signal output from the programming means and responsive thereto controlling the pressure exerted by the pressure means.
Claim 15
Independent Claim
162 words
A system for controlling blood flow in a reciprocating dialyzer apparatus, which comprises: means defining a blood chamber having a pressure responsive variable volume; pressure means connected with the blood chamber defining means for establishing the volume of the blood chamber; conduit means communicating with the blood chamber for blood flow therethrough to and from the blood chamber due to a change in volume of the blood chamber; first and second monitoring means for monitoring the rate of flow through the conduit means and for monitoring pressures exerted by the pressure means, and providing electrical signal outputs indicative thereof; programming means for receiving the electrical signal outputs from the monitoring means and establishing a program to effect cycling of blood flow through the conduit means to and from the blood chamber, the programming means providing a control signal output; and control means receiving the control signal output from the programming means and responsive thereto controlling the pressure exerted by the pressure means.
Claim 16
Dependent Claim
30 words
The system of Claim 12 wherein the second monitoring means is connected with the control means to monitor motor current as an indication of pressures exerted by the pressure means.
Claim 17
Dependent Claim
44 words
The system of Claim 12 wherein the programming means, responsive to the electrical signal outputs from the first and second monitoring means indicative of an unsafe condition for operation of the dialyzer apparatus, causes termination of blood flow or correction of the unsafe condition.
Claim 18
Independent Claim
72 words
A method for controlling biologic fluid flow, which comprises: sensing the rate of flow of biologic fluid in a path; sensing the amount of force necessary to produce fluid flow in the path; determining optimum flow rates for the fluid in the path in view of the sensed rate and sensed amount of force necessary to produce the flow rate; and controlling.the flow rate to maintain flow at said optimum flow rate.
Claim 19
Independent Claim
72 words
A method for controlling biologic fluid flow, which comprises: sensing the rate of flow of biologic fluid in a path; sensing the amount of force necessary to produce fluid flow in the path; determining optimum flow rates for the fluid in the path in view of the sensed rate and sensed amount of force necessary to produce the flow rate; and controlling.the flow rate to maintain flow at said optimum flow rate.
Claim 20
Dependent Claim
42 words
The method of Claim 15 wherein the method includes determining unsafe operating conditions from at least one of the rate of flow and/or amount of force sensing methods, and responsive thereto, varying the method to effect termination or correction of the operation.
Claim 21
Independent Claim
128 words
A method for controlling blood flow in a reciprocating dialyzer apparatus, which comprises: establishing a blood chamber having a pressure responsive volume; providing a pressure source capable of controlling the volume of the blood chamber; introducing blood into and withdrawing blood from the blood chamber through a single conduit; monitoring the blood flow in the conduit; monitoring the pressure exerted on the blood by the pressure source; establishing a program for cycling the blood into and out of the blood chamber under the control of the pressure source; modifying the program when the monitored blood flow and pressure are outside predetermined ranges; and using the modified program to vary the pressure of the pressure source to effect cycling of the blood into and out of the blood chamber.
Claim 22
Independent Claim
128 words
A method for controlling blood flow in a reciprocating dialyzer apparatus, which comprises: establishing a blood chamber having a pressure responsive volume; providing a pressure source capable of controlling the volume of the blood chamber; introducing blood into and withdrawing blood from the blood chamber through a single conduit; monitoring the blood flow in the conduit; monitoring the pressure exerted on the blood by the pressure source; establishing a program for cycling the blood into and out of the blood chamber under the control of the pressure source; modifying the program when the monitored blood flow and pressure are outside predetermined ranges; and using the modified program to vary the pressure of the pressure source to effect cycling of the blood into and out of the blood chamber.
Claim 23
Dependent Claim
40 words
The method of Claim 17 wherein the program is terminated if uncorrectable conditions causing unsafe operation are sensed by monitoring of the blood flow and pressure or when contaminants are sensed in the blood during monitoring of the blood flow.
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