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EP0049478A1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Multi-purpose blood diluent

Assignee: Avantor Performance Materials BV
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Filing: 1981-09-30
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Granted: —
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Expires: 2001-09-30
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Abstract

Abstract A multi-purpose blood diluent for blood cells for use in electronic counting and sizing of blood cells comprising a stable water solution of chemical salts providing an electrolytic solution to which a blood sample can be added to dilute the large number of red blood cells, white blood cells and other components and enable the desired parameters of these blood components to be measured, counted and determined. The diluent is azide-free and contains a bacteriostatic agent that substantially reduces the bubble formation capable of interfering with the determinations that resulted from the prior art use of 2-phenoxyethanol as the bacteriostatic agent. The diluent employs phenylethanol as the bacteriostatic agent and lithium chloride as the agent to stabilize red blood cell volume.

Inventors

  • 👤 Christiaan Elisabeth Raaijmakers

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 11:40
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5094; G01N33/96; G01N2496/00; G01N2496/05

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 79 words
A multi-purpose blood diluent, which is both isotonic and osmotically balanced relative to the solutions in blood cells, comprising: (a) an osmotically balanced solution of the chlorides of sodium and potassium and the mono- and di-hydrogen phosphate salts of sodium and potassium, (b) an ethylene diamine tetraacetic acid compound, (c) lithium chloride, and (d) phenylethanol, said diluent being an aqueous electroytic solution maintained at a pH between 7.0 and 8.5 and at an osmolality between 300 and 380 milliosmoles.
Claim 2
Dependent Claim 79 words
A multi-purpose blood diluent, which is both isotonic and osmotically balanced relative to the solutions in blood cells, comprising: (a) an osmotically balanced solution of the chlorides of sodium and potassium and the mono- and di-hydrogen phosphate salts of sodium and potassium, (b) an ethylene diamine tetraacetic acid compound, (c) lithium chloride, and (d) phenylethanol, said diluent being an aqueous electroytic solution maintained at a pH between 7.0 and 8.5 and at an osmolality between 300 and 380 milliosmoles.
Claim 3
Dependent Claim 25 words
The multi purpose diluent of claim 1 wherein the pH is maintained between pH 7.2 and 7.5 and the osmolality between 320 and 350 milliosmoles.
Claim 4
Dependent Claim 8 words
The multi-purpose diluent of claim 2 which comprises:

References Cited (Backward Citations)

US3962125A Cited
US4102810A Cited

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