EP0048901A1
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Plasma separator
Assignee: Terumo Corp
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Filing: 1981-09-17
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Granted: —
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Expires: 2001-09-17
Abstract
Abstract A filter membrane (16) housed in a casing (10) is a microporous membrane manufactured by the phase separation method an having a pore size of 0.1 to 0.8 µ, preferably 0.2 to 0.6 µ, and thickness of 100 to 300 µ. At least one membrane unit (11) consisting of such a membrane covering a core material (17) is arranged inside the casing to define a blood channel (12) of 50 to 150 µ channel thickness.
Inventors
- 👤 Masaharu Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 17:17
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/082; B01D63/084
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
177 words
A plasma separator having a casing (10, 44, 52) with a blood inlet port (13, 53), a filtrate outlet port (14, 55) for discharging filtered plasma, and a blood outlet port (15, 54), and at least one membrane unit (11, 42, 50) acting as a filter means arranged within the casing, said membrane unit comprising a filter membrane (11, 41, 62) and a core material (17, 40, 51) superposed one upon the other such that the core material is wrapped in the filter membrane, wherein blood introduced through the blood inlet port of the casing is continuously allowed to flow for plasma separation through a flat blood channel (12, 45, 61) formed within the casing (10, 44, 52) and having a constant channel thickness, characterized in that said filter membrane of said membrane unit (11, 42, 50) comprises a microporous membrane (16, 41, 62) prepared by the phase separation method and having a pore size of 0.1 to 0.8 p, and said channel thickness of said blood channel is within the range of 50 to 150 µ.
Claim 2
Dependent Claim
177 words
A plasma separator having a casing (10, 44, 52) with a blood inlet port (13, 53), a filtrate outlet port (14, 55) for discharging filtered plasma, and a blood outlet port (15, 54), and at least one membrane unit (11, 42, 50) acting as a filter means arranged within the casing, said membrane unit comprising a filter membrane (11, 41, 62) and a core material (17, 40, 51) superposed one upon the other such that the core material is wrapped in the filter membrane, wherein blood introduced through the blood inlet port of the casing is continuously allowed to flow for plasma separation through a flat blood channel (12, 45, 61) formed within the casing (10, 44, 52) and having a constant channel thickness, characterized in that said filter membrane of said membrane unit (11, 42, 50) comprises a microporous membrane (16, 41, 62) prepared by the phase separation method and having a pore size of 0.1 to 0.8 p, and said channel thickness of said blood channel is within the range of 50 to 150 µ.
Claim 3
Dependent Claim
23 words
The plasma separator according to claim 1, wherein said pore size of said microporous membrane (16, 41, 62) is 0.2 to 0.6 µ.
Claim 4
Dependent Claim
24 words
The plasma separator according to claim 1 or 2, wherein said microporous membrane (16, 41, 62) has a thickness of 100 to 300 µ.
Claim 5
Dependent Claim
15 words
The plasma separator according to claim 3, wherein said thickness is 150 + 20 µ.
Claim 6
Dependent Claim
21 words
The plasma separator according to claim 1, wherein said microporous membrane (16, 41, 62) has a porosity of 70 to 90%.
Claim 7
Dependent Claim
20 words
The plasma separator according to claim 1, wherein said microporous membrane (16, 41, 62) is made of a cellulose ester.
Claim 8
Dependent Claim
19 words
The plasma separator according to claim 6, wherein said microporous membrane (16, 41, 62) is made of cellulose acetate.
Claim 9
Dependent Claim
52 words
The plasma separator according to claim 1, wherein a pressure drop PD holds the relation 0 < PD ≦ 0.4 (kg/cm 2 ) and a shear rate γ̇ is within the range of 100 to 1,000 sec -1 when a blood flow rate is within the range of 50 to 500 mt/min.
Claim 10
Dependent Claim
35 words
The plasma separator according to claim 1, wherein said core material (17, 40, 51) comprises an open screen mesh having a filament diameter of 100 to 600 p and a mesh of 10 to 100/inch.
Claim 11
Dependent Claim
34 words
The plasma separator according to claim 9, wherein said core material (17, 40, 51) has a pitch of 100 to 400 µ of the protruding part and a thickness of 200 to 1200 µ.
Claim 12
Dependent Claim
22 words
ll. The plasma separator according to claim 1, wherein said core material (51) comprises a plate-shaped element having a rough outer surface.
Claim 13
Dependent Claim
57 words
The plasma separator according to claim 1, wherein a plurality of said membrane units (11, 42, 50) are piled inside said casing (10, 44, 52) with a predetermined distance between each pair of adjacent membrane units (11, 42, 50),' defining a blood channel (12, 45, 61) between each pair of said adjacent membrane units (11, 42, 50).
Claim 14
Dependent Claim
59 words
The plasma separator according to claim 12, wherein a plate-shaped spacer (30, 43, 56) is interposed between each pair of said adjacent membrane units (11, 42, 50) at a distance from said adjacent units and in a parallel relationship thereto, defining a blood channel (12, 45, 61) between surfaces of said spacer and the membrane unit opposing said spacer.
Claim 15
Dependent Claim
18 words
The plasma separator according to claim 10 or 13, wherein said spacer (30, 43) has a flat surface.
Claim 16
Dependent Claim
17 words
The plasma separator according to claim 13, wherein said spacer (30) has a rough outer surface (33).
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