EP0044090A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Lysosomotropic detergent therapeutic agents, compositions containing them and their uses
Assignee: Merck and Co Inc
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Filing: 1979-09-28
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Granted: —
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Expires: 1999-09-28
Abstract
Abstract Compounds of formula: in which M is a peptide substituent comprising z-gly-phe, gly-phe, z-arg-arg, or benzoyl-arg, and A or N=A is an active lysosome-inhibiting substance comprising a known therapeutic drug residue or an amino radical of the formula: in which R is an alkyl or substituted alkyl substituent of from 8 to 18 carbons and R 2 is fluoroalkyl or hydrogen, are useful in the control of fertility, in the inhibition of malignant cell growth, and in the control of other diseases which accumulate macrophages at the disease site. They can be incorporated in pharmaceutical compositions for this purpose.
Inventors
- 👤 Raymond A. Firestone
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 21:37
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61K; A61K31/00; A61K31/13; A61K31/15; A61K31/155; A61K31/21; A61K31/27; A61K31/275; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/425; A61K31/435; A61K31/44; A61K31/495; A61K31/535; A61K31/56; A61K31/575; A61K31/66; A61K31/675; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/545; A61K47/62; A61K47/64; A61P; A61P31/00; A61P31/04; A61P35/00; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08; C07J; C07J43/00; C07J43/003; C07J43/006; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07K5/06086; C07K5/06095; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
66 words
A compound of formula : in which M is a peptide substituent comprising z-gly-phe, gly - phe, z-arg-arg, or benzoyl-arg, and A or N=A is an active lysosome-inhibiting substance comprising a known therapeutic drug residue or an amino radical of the formula : in which R is an alkyl or substituted alkyl substituent of from 8 to 18 carbons and R 2 is fluoroalkyl or hydrogen.
Claim 2
Dependent Claim
66 words
A compound of formula : in which M is a peptide substituent comprising z-gly-phe, gly - phe, z-arg-arg, or benzoyl-arg, and A or N=A is an active lysosome-inhibiting substance comprising a known therapeutic drug residue or an amino radical of the formula : in which R is an alkyl or substituted alkyl substituent of from 8 to 18 carbons and R 2 is fluoroalkyl or hydrogen.
Claim 3
Dependent Claim
16 words
A pharmaceutical composition comprising a compound as claimed in Claim 1 together with a pharmaceutical carrier.
Claim 4
Independent Claim
42 words
A method for inhibiting or altering the function of lysosome-bearing cells that comprises contacting the said cells with a pharmaceutical composition comprising a pharmaceutical carrier and a lysosomotropic substance comprising a peptide conjugate hydrolysable by lysosomal enzymes to a biologically active substance.
Claim 5
Independent Claim
42 words
A method for inhibiting or altering the function of lysosome-bearing cells that comprises contacting the said cells with a pharmaceutical composition comprising a pharmaceutical carrier and a lysosomotropic substance comprising a peptide conjugate hydrolysable by lysosomal enzymes to a biologically active substance.
Claim 6
Dependent Claim
26 words
For use in inhibiting or altering the function of lysosome-bearing cells, a compound as claimed in Claim 1 or a composition as claimed in Claim 2.
References Cited (Backward Citations)
No citation records indexed.
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