Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
102 words
A process for the preparation of a substituted imidazole derivative of the formula: wherein each of R 1 , R 2 and R 3 , which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R 4 is hydrogen or an alkyl radical of 1 to 7 carbon atoms; and n is an integer from 0-3, or a non-toxic pharmaceutically acceptable acid addition salt thereof, which comprises dehydration of a compound of the formula: wherein R 1 , R 2' R 3 and R 4 are as defined above and n is 1-4.
Claim 2
Dependent Claim
102 words
A process for the preparation of a substituted imidazole derivative of the formula: wherein each of R 1 , R 2 and R 3 , which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R 4 is hydrogen or an alkyl radical of 1 to 7 carbon atoms; and n is an integer from 0-3, or a non-toxic pharmaceutically acceptable acid addition salt thereof, which comprises dehydration of a compound of the formula: wherein R 1 , R 2' R 3 and R 4 are as defined above and n is 1-4.
Claim 3
Dependent Claim
72 words
A process for the preparation of a substituted imidazole derivative of the formula I as defined in claim 1 or a non-toxic pharmaceutically acceptable acid addition salt thereof which comprises reacting an imidazole aldehyde of the formula wherein R 4 is as defined in claim 1, with an aralkylidenetriphenyl phosporane of the formula wherein R 1 , R 2 and R 3 are as defined in claim 1 and n is 0-3.
Claim 4
Dependent Claim
84 words
A process for the preparation of a substituted imidazole derivative of the formula I as defined in claim 1 or a non-toxic pharmaceutically acceptable acid addition salt thereof which comprises reacting a compound of the formula wherein R 1 , R 2 and R 3 are as defined in claim 1, X is a halogen atom or hydroxy, R 4 is hydrogen or methyl and n is 0-3, with a reagent capable of converting said starting material to the corresponding imidazole of formula (I).
Claim 5
Dependent Claim
13 words
A process according to claim 3, in which the said reagent is formamide.
Claim 6
Dependent Claim
21 words
A process according to claim 1 wherein the dehydration is performed by refluxing the said compound with an appropriate acidic solution.
Claim 7
Dependent Claim
23 words
A process according to claim 1 wherein the dehydration of the said compound is performed by heating it with anhydrous potassium hydrogen sulfate.