EP0033615A2
Expired / Lapsed
EP
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Therapeutic system for administering drugs to the skin
Assignee: Alza Corp
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Filing: 1981-01-22
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Granted: —
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Expires: 2001-01-22
Abstract
Abstract bandage for administering drugs to the skin that consists of an impermeable backing layer, a drug reservoir layer composed of drug and a carrier, and a contact adhesive layer by which the bandage is adhered to the skin. The contact adhesive layer controls the rate at which drug is administered and maintains that rate at an approximately constant level by virtue of there being a particular correlation between the solubility of the drug in the carrier and the contact adhesive, the diffusion coefficient of the drug in the carrier and in the contact adhesive, the concentration of drug in the reservoir, and the thickness of the contact adhesive layer.
Inventors
- 👤 Santosh K. Chandrasekaren
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 04:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61F; A61F13/00; A61F13/00051; A61F13/00063; A61F13/02; A61F13/0246; A61F13/0256; A61K9/7084; A61F13/15; A61F13/84; A61F13/8405; A61F2013/00361; A61F2013/00902; A61F2013/00906; A61F13/51; A61F13/514; A61F13/51401; A61F2013/51409; A61K9/0012; A61K9/0053; A61K9/006
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
240 words
A bandage for administering a drug to the skin or mucosa for a predetermined time period, with t representing a time, in hours, in said time period, comprising a sandwich type laminate of: (a) a backing lamina that is substantially impermeable to the drug, one face of which forms the top of the bandage; (b) a drug reservoir lamina adjacent the opposite face of the backing lamina comprising the drug dispersed in a carrier that is permeable to the drug, with the solubility of the drug in the carrier being C SDR mg/cm 3 , the diffusion coefficient of drug in the carrier being D DR cm 2 /hr, and the concentration of drug in the drug reservoir being C DR mg/cm 3 ; and (c) a contact adhesive lamina adjacent and below the drug reservoir lamina comprising a contact adhesive composition that is permeable to the drug, with the thickness of the contact adhesive lamina being CA cm, the solubility of the drug in the contact adhesive composition being C SCA mg/cm 3 , the diffusion coefficient of drug in the contact adhesive composition being DCAcm2/hr, and the concentration of drug in the contact adhesive composition being C CA mg/cm 3 , characterised in that over at least a substantial portion of said time period (i) C CA is not greater than C SCA , and (ii) the ratio is in the range of about 0.01 to about 0.7.
Claim 2
Dependent Claim
240 words
A bandage for administering a drug to the skin or mucosa for a predetermined time period, with t representing a time, in hours, in said time period, comprising a sandwich type laminate of: (a) a backing lamina that is substantially impermeable to the drug, one face of which forms the top of the bandage; (b) a drug reservoir lamina adjacent the opposite face of the backing lamina comprising the drug dispersed in a carrier that is permeable to the drug, with the solubility of the drug in the carrier being C SDR mg/cm 3 , the diffusion coefficient of drug in the carrier being D DR cm 2 /hr, and the concentration of drug in the drug reservoir being C DR mg/cm 3 ; and (c) a contact adhesive lamina adjacent and below the drug reservoir lamina comprising a contact adhesive composition that is permeable to the drug, with the thickness of the contact adhesive lamina being CA cm, the solubility of the drug in the contact adhesive composition being C SCA mg/cm 3 , the diffusion coefficient of drug in the contact adhesive composition being DCAcm2/hr, and the concentration of drug in the contact adhesive composition being C CA mg/cm 3 , characterised in that over at least a substantial portion of said time period (i) C CA is not greater than C SCA , and (ii) the ratio is in the range of about 0.01 to about 0.7.
Claim 3
Dependent Claim
85 words
The bandage of claim 1 further characterised in that C SDR is in the range of 0.1 and 100 mg cm 3 , C SCA is in the range of 0.1 and 100 mg cm 3 , cm2/sec , D DR is in the range of 1 x 10 -11 and 1 x 10 -7 cm2/sec , D CA is in the range of 1 x 1.0 -11 and 1 x 10 -7 and CA is in the range of 50 microns and 2 mm.
References Cited (Backward Citations)
No citation records indexed.
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