EP0031727A2
Expired / Lapsed
EP
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Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1980-12-29
•
Granted: —
•
Expires: 2000-12-29
Abstract
Abstract A mammal suffering from ischemic disease such as cerebral apoplexy, cadiac insufficiency, renal insufficiency due to hypertensive vasculer lesions, etc. is remedied by administering to said mammal an effective amount of a compound of the formula: wherein n is an integer of from 4 to 22.
Inventors
- 👤 Isuke Imada
- 👤 Akinobu Nagaoka
- 👤 Minoru Hirata
- 👤 Tetsuya Okutani
- 👤 Giichi Goto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 12:25
CPC Classifications
C; C07; C07C; C07C43/00; C07C43/02; C07C43/20; C07C43/23; A; A61; A61P; A61P25/00; A61P25/28; A61P43/00; C07C45/00; C07C45/61; C07C45/67; C07C45/673; C07C46/00; C07C46/02; C07C46/06; C07C46/08; C07C50/00; C07C50/26; C07C50/28
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
37 words
A method for treatment of a mammal suffering from ischemic disease, which comprises administering to said mammal an effective amount of a compound of the formula: • wherein n is an integer of from 4 to 22.
Claim 2
Independent Claim
37 words
A method for treatment of a mammal suffering from ischemic disease, which comprises administering to said mammal an effective amount of a compound of the formula: • wherein n is an integer of from 4 to 22.
Claim 3
Dependent Claim
18 words
A method as claimed in Claim 1, wherein the ischemic disease is a cerebral, cardiac or renal disease.
Claim 4
Dependent Claim
23 words
A method as claimed in Claim 1, wherein the ischemic disease is cerebral apoplexy, cardiac insufficiency or renal insufficiency due to vascular changes.
Claim 5
Dependent Claim
41 words
A method as claimed in Claim 1, wherein the ischemic disease is cerebral infarction, cerebral hemorrhage, cerebral hemorrhagic infarction, cerebral embolus, cardiac infarction, angina pectoris, cardiac failure, congestive heart failure, coronary insufficiency, nephrosclerosis, proteinuria due to vascular lesions or renovascular hypertension.
Claim 6
Dependent Claim
30 words
A method as claimed in Claim 1, wherein the effective amount of the compound is 0.02 mg to 60 mg per kilogram of body weight of the mammal per day.
Claim 7
Dependent Claim
32 words
A method as claimed in Claim 1, wherein the compound is administered orally in an amount'of about 0.1 mg to 12 mg per kilogram of body weight of the mammal per day.
Claim 8
Dependent Claim
33 words
A method as claimed in Claim 1, wherein the compound is administered intravenously in an amount of about 0.06 mg to 2 mg per kilogram of body weight of the mammal per day.
Claim 9
Dependent Claim
20 words
A method as claimed in Claim 1, wherein n in the formula is an integer of from 6 to 18.
Claim 10
Dependent Claim
12 words
A method as claimed in Claim 1, wherein the compound is 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone.
Claim 11
Dependent Claim
13 words
A method as claimed in Claim 1, wherein the compound is 2,3-dimethoxy-5-methyl-6-(11-hydroxyundecyl) -1,4-benzoquinone.
Claim 12
Dependent Claim
13 words
A method as claimed in Claim 1, wherein the compound is 2,3-dimethoxy-5-methyl-6-(12-hydroxydodecyl) -1,4-benzoquinone.
Claim 13
Dependent Claim
13 words
A method as claimed in Claim 1, wherein the compound is 2,3-dimethoxy-5-methyl-6-(13-hydroxytridecyl) -1,4-benzoquinone.
Claim 14
Dependent Claim
48 words
A medicinal composition for the treatment of a mammal suffering from ischemic disease, which comprises , as an active ingredient, an effective amount of a compound of the formula: wherein n is an integer of from 4 to 22, and a physiologically acceptable carrier, excipient or diluent therefor.
Claim 15
Dependent Claim
48 words
A medicinal composition for the treatment of a mammal suffering from ischemic disease, which comprises , as an active ingredient, an effective amount of a compound of the formula: wherein n is an integer of from 4 to 22, and a physiologically acceptable carrier, excipient or diluent therefor.
Claim 16
Dependent Claim
20 words
A compositon as claimed in Claim 13, wherein n in the formula is an integer of from 11 to 22.
Claim 17
Dependent Claim
16 words
A composition as claimed in Claim 13, which is in the form of a dosage unit.
Claim 18
Dependent Claim
26 words
A composition as claimed in Claim 13, wherein the active ingredient is present in an amount of from 0.3 mg to 100 mg per dosage unit.
Claim 19
Dependent Claim
21 words
The use for a therapeutic agent of the compound(I) or the composition as defined in any of Claims 13 to 16.
References Cited (Backward Citations)
No citation records indexed.
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