EP0028126A1
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EP
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Material produced from cross-linked ionic chitin derivative, its preparation and use
Assignee: Kureha Corp
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Filing: 1980-10-22
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Granted: —
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Expires: 2000-10-22
Abstract
Abstract Problems have occurred using chitin derivatives having surface ionic groups as ion-exchangers. These problems can be overcome by employing a material produced by acylating or treating with an acid the surface of a material composed of a cross-lined ionic chitin derivative. The acylation or acid treatment eliminates the surface ionic groups, for example by converting them to non-ionic groups. The resulting material can also be employed in dialysis and in the separation and purification of glycoproteins.
Inventors
- 👤 Junichi Koshugi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 23:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01D; B01D15/00; B01D15/08; B01D71/00; B01D71/06; B01D71/08; B01J; B01J20/00; B01J20/22; B01J20/24; B01J39/00; B01J39/08; B01J39/16; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003; C12; C12N; C12N11/00; C12N11/02; C12N11/10; B01D15/26; B01D15/36; B01D15/361; B01D15/38; B01D15/3804
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
129 words
A material produced by,acylating or treating with an acid a surface of a material composed of a cross-linked ionic chitin derivative comprising a structural unit represented by the formula: wherein R 1 denotes a hydrogen atom, a group of formula C n H 2n+1 ' a group of formula-(CH 2 ) n OH or a group of formula -CO(CH 2 ) n-1 CH 3 and R denotes a hydrogen atom, a group of formula -C n ,H 2n'+1' a group of formula a group of formula or a group of formula -(CH2) COOM, wherein n is an integer of 1 to 20, n' is an integer of 1 to 3, and M is a hydrogen atom, an alkali metal or an atomic equivalent amount of an alkaline earth metal.
Claim 2
Dependent Claim
129 words
A material produced by,acylating or treating with an acid a surface of a material composed of a cross-linked ionic chitin derivative comprising a structural unit represented by the formula: wherein R 1 denotes a hydrogen atom, a group of formula C n H 2n+1 ' a group of formula-(CH 2 ) n OH or a group of formula -CO(CH 2 ) n-1 CH 3 and R denotes a hydrogen atom, a group of formula -C n ,H 2n'+1' a group of formula a group of formula or a group of formula -(CH2) COOM, wherein n is an integer of 1 to 20, n' is an integer of 1 to 3, and M is a hydrogen atom, an alkali metal or an atomic equivalent amount of an alkaline earth metal.
Claim 3
Dependent Claim
25 words
A material according to claim 1 wherein the cross-linked ionic chitin derivative has a degree of cross-linking of from 0.01 to 0.3 per pyranose unit.
Claim 4
Dependent Claim
26 words
A material according to claim 1 or 2 wherein the cross-linked ionic chitin derivative has a degree of R 2 substitution of from 0.1 to 0.9.
Claim 5
Dependent Claim
22 words
A material according to claim 3 wherein the cross-linked ionic chitin derivative has a degree of carboxyalkylation of from 0.3 to 0.9.
Claim 6
Dependent Claim
25 words
A material according to any one of,the preceding claims wherein the cross-linked ionic chitin derivative has a degree of de-acetylation of from 0.1 to 1.0.
Claim 7
Dependent Claim
42 words
A material according to any one of the preceding claims wherein the acylation or treatement with acid has caused the formation of one or more of chitin, 0-acylated chitin, N-acylated chitosan, and N-,O-diacylated chitosan on at least the surface of the material.
Claim 8
Dependent Claim
93 words
A process for the preparation of a material as claimed in any one of the preceding claims, which process comprises: (i) cross-linking natural chitin or regenerated chitin with a cross-linking agent, (ii) reacting the cross-linked chitin with an etherifying agent to introduce the OR 2 group at the 3- or 6- position of the pyranose ring of structural units of the cross-linked chitin, wherein R 2 is as defined in claim 1, (iii) de-acetylating the cross-linked etherified chitin, and (iv) acylating or treating with acid the surface of the de-acetylated, cross-linked, etherified chitin.
Claim 9
Dependent Claim
79 words
Use of a material as claimed in any one of claims 1 to 6 or which has been produced by a process as claimed in claim 7 in dialysis, as an ion-exchanger, for collecting heavy metals, as a base material on which an enzyme, antigen or antibody is to be immobilised, in ultrafiltration, in the purification and separation of glycoproteins, as an adsorbent for internal administration to adsorb and remove gastrointestinal toxins or as a covering material for adsorbents.
References Cited (Backward Citations)
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