EP0023789A2
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Process for preparing porous acylated chitin derivative and use of said derivative
Assignee: Kureha Corp
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Filing: 1980-07-18
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Granted: —
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Expires: 2000-07-18
Abstract
Abstract Acylated chitin derivatives prepared by acylating a soluble derivative of chitin using an organic acid anhydride hitherto have not been able to effectively adsorb or separate substances with a molecular weight greater than 70,000. This problem has now been overcome by effecting acylation in the presence of a diluent, a porosity-regulating agent and one or more surfactant so as to obtain a porous acylated chitin derivative. In one embodiment an aqueous solution of the soluble derivative of chitin containing the diluent, the porosity-regulating agent and a surfactant is contacted with a liquid containing the organic acid anhydride and a surfactant. Typically, the porosity regulating agent is benzene or a volatile alkylbenzene, such as toluene or xylene, and the surfactant is a monolaurate, monopalmitate, monostearate, monooleate or trioleate of sorbitan or of polyoxyethylene sorbitan. The porous product can be employed as an ion-exchanger or in chromatographic columns as a filler.
Inventors
- 👤 Junichi Koshugi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 17:42
CPC Classifications
C; C08; C08J; C08J9/00; C08J9/28; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; B; B01; B01D; B01D15/00; B01D15/08; B01D71/00; B01D71/06; B01D71/08; B01J; B01J20/00; B01J20/22; C08L; C08L5/00; C08L5/08; C12; C12N; C12N11/00; C12N11/02; C12N11/10; B01D15/26; B01D15/36; B01D15/361; B01D15/38; B01D15/3804; C08J2305/00; C08J2305/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
49 words
A process for producing an acylated chitin derivative by acylating a soluble derivative of chitin using an organic acid anhydride characterised in that acylation is effected in the presence of a diluent, a porosity-regulating agent and one or more surfactant so as to obtain a porous acylated chitin derivative.
Claim 2
Dependent Claim
49 words
A process for producing an acylated chitin derivative by acylating a soluble derivative of chitin using an organic acid anhydride characterised in that acylation is effected in the presence of a diluent, a porosity-regulating agent and one or more surfactant so as to obtain a porous acylated chitin derivative.
Claim 3
Dependent Claim
95 words
A process according to claim 1 characterised in that said soluble derivative of chitin is a compound represented by the general formula (I): wherein R represents at least one group selected from a carboxyalkyl group with two to four carbon atoms, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group or an alkyl group with one to three carbon atoms; x is a number of from 0.1 to 1.0; y = 1.0 - x, a is a number of from 0 to 1.0 and b = 1 . 0 - a. or a salt thereof.
Claim 4
Dependent Claim
63 words
A process according to claim 1 or 2 characterised in that said diluent is an alcohol with one to four carbon atoms, pyridine, an ether represented by the general formula: wherein R and R' independently represent a hydrogen atom or an alkyl group with one to four carbon atoms and n represents an integer of 1, 2 or 3, or a mixture thereof.
Claim 5
Dependent Claim
22 words
A process according to any one of the preceding claims characterised in that said porosity-regulating agent is benzene or a volatile alkylbenzene..
Claim 6
Dependent Claim
16 words
A process according to claim 4, characterised in that said volatile alkylbenzene is toluene or xylene.
Claim 7
Dependent Claim
29 words
A process according to any one of the preceding claims, characterised in that said surfactant is a monolaurate, monopalmitate, monostearate, monooleate or trioleate of sorbitan or of polyoxyethylene sorbitan.
Claim 8
Dependent Claim
45 words
A process according to any one of the preceding , claims characterised in that an aqueous solution of the soluble derivative of chitin containing the diluent, the porosity-regulating agent and a surfactant is contacted with a liquid containing the organic acid anhydride and a surfactant.
Claim 9
Dependent Claim
52 words
A process according to claim 7, characterised in that said aqueous solution contains from 0.1 to 5 parts by weight of said diluent, from 0.001 to 1 parts by weight of said porosity-regulating agent and from 0.001 to 0.1 parts by weight of surfactant per part by weight of said aqueous solution.
Claim 10
Dependent Claim
31 words
A process according to claim 7 or 8, characterised in that the concentration of said soluble derivative of chitin in said aqueous solution is from 0.1 to 10 % by weight.
Claim 11
Dependent Claim
34 words
A process according to any one of claims 7 to 9, characterised in that the concentration of surfactant in said liquid containing said organic acid anhydride is from 0.01 to 0.1 % by weight.
Claim 12
Dependent Claim
20 words
A process according to any one of the preceding claims characterised in that the porous acylated chitin derivative is cross-linked.
Claim 13
Dependent Claim
65 words
Use of an acylated chitin derivative which has been prepared by a process as claimed in any one of the preceding claims as an ion-exchanger, in a chromatographic column as a filler, as a base material on which an enzyme, antibody or antigen is to be immobilised, in blood perfusion,as an adsorbent, to coat an adsorbent or to form a polyion with an anti-thrombogenic substance.
References Cited (Backward Citations)
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