EP0022478B1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same
Assignee: Merck and Co Inc
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Filing: 1980-06-12
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Granted: 1983-02-23
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Expires: 2000-06-12
Abstract
No abstract record available.
Inventors
- 👤 Richard L. Monaghan
- 👤 Alfred W. Alberts
- 👤 Carl H. Hoffman
- 👤 George Albers-Schonberg
- 👤 Henry Joshua
- 👤 Maria B. Lopez Aguirre
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 07:34
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; A; A61; A61P; A61P3/00; A61P3/06; C12; C12N; C12N1/00; C12N1/14; C12N1/145; C12P; C12P17/00; C12P17/02; C12P17/06; C12P7/00; C12P7/62; C12R; C12R2001/00; C12R2001/645; C12R2001/66
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
4 words
A compound selected from
Claim 2
Dependent Claim
4 words
A compound selected from
Claim 3
Dependent Claim
28 words
A compound selected from: or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 4
Dependent Claim
28 words
A compound selected from: or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 5
Dependent Claim
23 words
The pharmaceutically acceptable salts of the compounds of Claim 2, wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
Claim 6
Dependent Claim
11 words
The ammonium salt of compound III or IV of Claim 2.
Claim 7
Dependent Claim
15 words
The lower alkyl esters and substituted lower alkyl esters of the compound of Claim 2.
Claim 8
Dependent Claim
11 words
The ethyl ester of Compound III or IV of Claim 2.
Claim 9
Dependent Claim
27 words
A process of producing the compounds of structural formulae: which comprises fermenting a nutrient medium with a microorganism of the species Aspergillus terreus and isolating the products.
Claim 10
Dependent Claim
27 words
A process of producing the compounds of structural formulae: which comprises fermenting a nutrient medium with a microorganism of the species Aspergillus terreus and isolating the products.
Claim 11
Dependent Claim
24 words
The process of claim 7 in which the microorganism is one deposited in the American Type Culture Collection with Accession number 20541 or 20542.
Claim 12
Dependent Claim
21 words
The process of claim 7 in which the isolation comprises extraction of the fermentation mixture with a solvent followed by chromatography.
Claim 13
Dependent Claim
22 words
A pharmaceutical composition comprising a pharmaceutical carrier and an effective amount of a compound of any one of Claims 1 to 6.
References Cited (Backward Citations)
No citation records indexed.
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