EP0016652A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Composition for the controlled release of an active substance and process for its preparation
Assignee: BTG International Ltd
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Filing: 1980-03-21
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Granted: —
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Expires: 2000-03-21
Abstract
Abstract A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
Inventors
- 👤 Mostyn Powell Embrey
- 👤 Neil Bonnette Graham
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 11:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K31/00; A61K31/557; A61K9/0012; A61K9/0034; A61K9/0036; C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/48; C08G18/4833; C08G18/65; C08G18/66; C08G18/6666; C08G18/667; C08G18/6674; C08G18/6677; C08G2210/00; C08G2250/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
42 words
A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
Claim 2
Dependent Claim
42 words
A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
Claim 3
Dependent Claim
22 words
A composition according to Claim 1 wherein the residues have a ratio of number average molecular weight to functionality greater than 1,500.
Claim 4
Dependent Claim
22 words
A composition according to Claim 2 wherein the residues have a ratio of number average molecular weight to functionality greater than 2,000.
Claim 5
Dependent Claim
25 words
A composition according to any preceding claim wherein the polymeric carrier is a crystalline-hydrogel in the dry form and exhibits syneresis in the wet form.
Claim 6
Dependent Claim
47 words
A composition according to any preceding claim wherein the polyethylene oxide is the reaction product of a mixture comprising (i) an aliphatic or aromatic compound which is di, tri or tetra substituted by at least one of hydroxyl, carboxyl, amino or mercapto groups with (ii) ethylene oxide.
Claim 7
Dependent Claim
16 words
A composition according to Claim 5 wherein (i) comprises a di- or tri hydroxyl-substituted aliphatic compound.
Claim 8
Dependent Claim
39 words
A composition according to any preceding claim wherein the degree of cross-linking of the polymeric carrier is from 3 urethane groups linked to one residue comprising polyethylene oxide To one urethane group linked to 10 residues comprising polyethylene oxide.
Claim 9
Dependent Claim
20 words
A composition according to any preceding claim wherein the polymeric carrier comprises a minor amount of an additional polyalkylene oxide.
Claim 10
Dependent Claim
34 words
A composition according to any preceding claim wherein the polymeric carrier comprises a minor amount of an additional polyethylene oxide having a ratio of number average molecular weight to functionality not greater than 1000.
Claim 11
Dependent Claim
19 words
A composition according to any preceding claim wherein the polymeric carrier comprises a minor amount of a water-extractable fraction.
Claim 12
Dependent Claim
21 words
A composition according to Claim 10 wherein the polymeric carrier comprises up to 30% of its weight of a water-extractable fraction.
Claim 13
Dependent Claim
25 words
A composition according to-Claim 10 or 11 wherein the amount of water-extractable fraction has been reduced to no more than 5% of the polymeric carrier.
Claim 14
Dependent Claim
21 words
A composition according to any preceding claim wherein the residues comprising polyethylene oxide comprise at least 70% of the polymeric carrier.
Claim 15
Dependent Claim
15 words
A composition according to any preceding claims where the residues consist substantially of polyethylene oxide.
Claim 16
Dependent Claim
18 words
A composition according to any preceding claim wherein the active substance comprises a drug other than a prostaglandin.
Claim 17
Dependent Claim
37 words
A composition according to Claim 15 wherein the drug is a hypnotic, sedative, tranquilliser, anti-pyretic, anti-inflammatory agent, anti-histamine, anti-tussive, agent for the treatment of malignant neoplastia, topical or dermatological agent, agent, anti-depressant, anti-fungal agent, steroid or analgesic.
Claim 18
Dependent Claim
16 words
A composition according to any preceding claims in the shape of a cylinder, film or slab.
Claim 19
Dependent Claim
31 words
1 8. A composition according to Claim 17 wherein the cylinder is hollow or the film or slab has one or more holes or hollows therein to modify the release properties.
Claim 20
Dependent Claim
19 words
A composition according to any preceding claim wherein the active substance comprises a fungicide, algaecide, herbicide, nematocide or insecticide.
Claim 21
Dependent Claim
18 words
A composition according to any of Claims 1 to 14, wherein the active substance comprises a polymerisation inhibitor.
Claim 22
Dependent Claim
73 words
A process for the preparation of a controlled release composition according to any preceding claim which comprises fabricating a polymeric carrier as defined in any of Claims 1 to 14 in any desired form; contacting the polymeric carrier with a solution of an active substance and permitting it to swell therein; removing the swollen polymeric carrier from the solution; and, optionally, drying it, thereby providing a controlled release composition comprising the active substance.
Claim 23
Dependent Claim
29 words
A process according to Claim 21 wherein the permitted swelling if the polymeric carrier is from 200 to 700 parts by volume per hundred of the initial dry volume.
Claim 24
Dependent Claim
23 words
A process according to Claim 21 or 22 wherein the swelling is effected at a temperature from -20 C to +20 o C.
Claim 25
Independent Claim
53 words
A method of controlled administration to a human or non-human animal patient of a biologically active substance other than a grostaglandin which comprises incorporating the active substance .nto a controlled release composition according to any of Claims 1 o 19; and applying the composition to the part of the patient .o be treated.
References Cited (Backward Citations)
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