EP0016633A2
Expired / Lapsed
EP
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Blood gas controls composition, method and apparatus
Assignee: Ortho Clinical Diagnostics Inc
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Filing: 1980-03-19
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Granted: —
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Expires: 2000-03-19
Abstract
Abstract A hermetically sealed ampoule containing blood gas control fluid is provided wherein the fluid occupies the entire ampoule with no appreciable head space. The blood gas control fluid comprises water, dissolved Co 2 , O 2 and one or more of a water soluble buffer. The ampoule is provided with a plunger-like seal (11) adapted to be directed against the contents (10) of the ampoule and a pierceable seal (12) through which may extend a hollow needle to act as a conduit for the contents upon expulsion from the ampoule. A syringe is also provided for expelling the contents from the ampoule.
Inventors
- 👤 Michael Kevin Hoskins
- 👤 Gary Dale Christiansen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 14:05
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/06; A61J1/062; G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4925; G01N33/50; G01N33/96; G01N2496/00; G01N2496/25; G01N2496/30; G01N2496/70; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
42 words
A device comprising a hermetically sealed, gas-impermeable container containing a blood gas control-liquid and having essentially no bubbles or gaseous head space, said liquid comprising a. dissolved carbon dioxide b. dissolved oxygen c. one or more of a water-soluble buffer d. -water
Claim 2
Independent Claim
42 words
A device comprising a hermetically sealed, gas-impermeable container containing a blood gas control-liquid and having essentially no bubbles or gaseous head space, said liquid comprising a. dissolved carbon dioxide b. dissolved oxygen c. one or more of a water-soluble buffer d. -water
Claim 3
Dependent Claim
37 words
The device of Claim 1 wherein the carbon dioxide is obtained from a bicarbonate source and is present in an amount sufficient to provide a partial pressure of CO 2 of from 10 to 80 mm Hg.
Claim 4
Dependent Claim
32 words
or Claim 2 3. The device of Claim 1/wherein the oxygen is present in an amount sufficient to provide a partial pressure of O 2 of from 30 to 170 mm Hg.
Claim 5
Independent Claim
18 words
The device of any one of Claims 1 to 3 having a pH of from 7.0 to 7.7.
Claim 6
Independent Claim
64 words
The device of any one of Claims 1 to 4 wherein there is additionally present sodium chloride in a concentration of from 1.5 to 2.0 gms. per liter, the oxygen concentration is sufficient to provide a PO 2 level of 30 to 170 mm Hg, and the CO 2 concentration is sufficient to provide a pCO 2 level of 10 to 80 mm Hg.
Claim 7
Dependent Claim
25 words
any one of to 5 6. The device of / Claims1/wherein the buffer comprises one or more of alkali metal mono or di-basic phosphate salts.
Claim 8
Independent Claim
25 words
The device of any one of Claims 1 to 6 wherein the CO 2 is provided from an alkali metal or alkaline earth metal bicarbonate.
Claim 9
Independent Claim
18 words
The device of any one of Claims 1 to 7 wherein the oxygen is provided from a peroxide.
Claim 10
Dependent Claim
11 words
The device of Claim 8 wherein the peroxide is hydrogen peroxide.
Claim 11
Independent Claim
19 words
The device of any one of Claims 1 to 7 wherein the oxygen is provided by dissolved gaseous oxygen..
Claim 12
Independent Claim
35 words
The device of any one of Claims 1 to 10 wherein the buffer is selected from one or more of sodium monobasic phosphate, sodium di-basic phosphate, potassium monobasic phosphate, potassium di-basic phosphate and mixtures thereof.
Claim 13
Independent Claim
25 words
The device of any one of Claims 1 to 8 wherein the carbon dioxide source is sodium bicarbonate and the oxygen source is hydrogen peroxide.
Claim 14
Dependent Claim
26 words
The composition of any one of Claims 1 to 7 wherein the carbon dioxide source is sodium bicarbonate and the oxygen source is dissolved gaseous oxygen.
Claim 15
Independent Claim
28 words
The device of any one of Claims 1 to 13 wherein said container is essentially clear to the transmission of light thereby permitting visual inspection of said composition.
Claim 16
Dependent Claim
55 words
The device of Claim 9 wherein the sodium chloride concentration is from 1.5 to 2.0 gms. per liter, the dissolved oxygen concentration is sufficient to provide a PO 2 level of 30 to 170 mm Hg, and the CO 2 level is sufficient to provide a pCO 2 level of 10 to 80 mm Hg.
Claim 17
Dependent Claim
61 words
A container comprising a chamber having at least two hermetically sealed ends, a first seal being adapted to be moved against the contents of the container in piston-like fashion, and a second seal being adapted to be pierced by a sharp needle-like point, whereby said contents may be expelled from said container upon movement of said first seal against said contents.
Claim 18
Dependent Claim
61 words
A container comprising a chamber having at least two hermetically sealed ends, a first seal being adapted to be moved against the contents of the container in piston-like fashion, and a second seal being adapted to be pierced by a sharp needle-like point, whereby said contents may be expelled from said container upon movement of said first seal against said contents.
Claim 19
Dependent Claim
13 words
The container of Claim 16 wherein said seals and said chamber are gas-impermeable.
Claim 20
Dependent Claim
14 words
Claim 16 or 18. The container of/Claim 17 wherein said chamber is generally tubular.
Claim 21
Dependent Claim
21 words
The container of Claim 18 wherein there are two hermetically sealed ends and said seals are made of gas-impermeable butyl rubber.
Claim 22
Dependent Claim
22 words
The container of/Claims 16/wherein the chamber is made of clear glass so that the contents thereof are visible to the naked eye.
Claim 23
Dependent Claim
95 words
A syringe for expelling the contents of a container claimed in any one of Claims 16 to 20 which comprises a) barrel portion having two ends, b) a piston rod having a non-piercing end at one end of said barrel, and c) a fitting at the other end comprising a hollow needle extending into the barrel to communicate with said container, said needle being positioned at a point sufficient to pierce the pierceable end of said container and extend into said chamber when the piston end of said container is directed against said first seal.
Claim 24
Dependent Claim
41 words
A blood gas control composition which comprises a) water b) dissolved CO 2 c) dissolved oxygen from a water soluble or water suspendible peroxide d) one or more of a water soluble buffer e) said composition having a pH of 7.0-7.7.
Claim 25
Dependent Claim
41 words
A blood gas control composition which comprises a) water b) dissolved CO 2 c) dissolved oxygen from a water soluble or water suspendible peroxide d) one or more of a water soluble buffer e) said composition having a pH of 7.0-7.7.
Claim 26
Dependent Claim
32 words
The composition of claim 22 wherein the source of dissolved oxygen is hydrogen peroxide and the dissolved C0 2 is provided by an alkali metal or alkaline earth metal carbonate or bicarbonate.
Claim 27
Dependent Claim
38 words
The composition of Claim 22 or claim 23 wherein the dissolved oxygen is present at a level of from 30-170 mm Hg, the dissolved CO 2 is present at a level of from 10 to 80 mm Hg.
Claim 28
Dependent Claim
24 words
any one of to 24 25. The composition of/claims 22/wherein the buffer comprises one or more of alkali metal mono and di-basic phosphate salts.
Claim 29
Dependent Claim
14 words
The composition of/claims 22/wherein the composition has a pH of from 7.1 to 7.6.
Claim 30
Dependent Claim
93 words
The method for delivering a control liquid to a locus of testing which comprises: to 20 providing the container of any one of claims 16 to 20 having a control liquid therein within the barrel portion of the syringe of claim 21 and directing the piston rod of said syringe against the first seal of said container with sufficient force to cause the hollow needle of said syringe to pierce the second seal of said container, thereby to expel at least part of the contents of the container to the locus of testing.
References Cited (Backward Citations)
No citation records indexed.
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