EP0014514A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Process for the preparation of tablets
Assignee: Orion Oyj
•
Filing: 1980-01-02
•
Granted: —
•
Expires: 2000-01-02
Abstract
Abstract A process for making matrix-type tablets with retarded liberation of the active agent. The matrix is of a polymethacrylate plastics material. Before the tablets are compressed, an ester of a large-molecule fatty acid or a derivative thereof produced by hydrogenation is added to the mixture as a controlling agentto adjust the rate of liberation of the active agent.
Inventors
- 👤 Gunnar Aslak Sothmann
- 👤 Esko Veikko Marttila
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 02:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2022; A61K9/2027
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
111 words
A process for the preparation of matrix-type tablets with retarded liberation of the active agent in which the liberation of the active agent takes place at a predetermined speed, characterized in that . the retarding matrix substance used in the granulation process comprises a methacrylate polymer, insoluble in neutral or slightly acid water either in solution in an organic solvent or as a dispersion in water and that, before the tablets are compressed, an ester of a high molecular weight fatty acid or a derivative thereof produced by hydrogenation is mixed into the grain mix as a controlling agent in order to adjust the rate of liberation of the active agent.
Claim 2
Dependent Claim
111 words
A process for the preparation of matrix-type tablets with retarded liberation of the active agent in which the liberation of the active agent takes place at a predetermined speed, characterized in that . the retarding matrix substance used in the granulation process comprises a methacrylate polymer, insoluble in neutral or slightly acid water either in solution in an organic solvent or as a dispersion in water and that, before the tablets are compressed, an ester of a high molecular weight fatty acid or a derivative thereof produced by hydrogenation is mixed into the grain mix as a controlling agent in order to adjust the rate of liberation of the active agent.
Claim 3
Dependent Claim
44 words
A process as claimed in claim 1 characterised in that a copolymerizate of acrylic and methacrylic acid esters containing quarternary ammonium groups, or a copolymerizate of methacrylic acid and methyl ester of methacrylic acid with anionic character is used as the retarding matrix substance.
Claim 4
Dependent Claim
36 words
A process as claimed in claim 1, characterised in that a water dispersion of a copolymerizate of methyl and ethyl esters of acrylic and methacrylic acid with neutral character is used as the retarding matrix substance.
Claim 5
Dependent Claim
31 words
A process according to any preceding claim characterized in that as the controller agent for the rate of the active agent is used hydrogenated castor oil or hydrogenated cotton seed oil.
Claim 6
Dependent Claim
41 words
A process according to any preceding claim wherein the said controlling agent is selected from glycerides of acids of formula C 11 to 23H23 to 47 COOH and C 10 to 3 oH21 to 61 CH- esters of the same acids.
Claim 7
Dependent Claim
34 words
A process according to any one of claims 1 to 4, characterized in that the quantity of the controlling agent is not more than 30 wt.% based on the gross weight of the tablets.
Claim 8
Dependent Claim
29 words
A process according to claim 5 characterized in that the quantity of the controlling agent is not more than 15 wt.% based on the gross weight of the tablets.
Claim 9
Dependent Claim
11 words
Matrix-type tablets made by a process according to any preceding claim.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.