EP0013262A2
Expired / Lapsed
EP
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A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, and a process for preparation thereof
Assignee: Hassle AB
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Filing: 1979-12-13
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Granted: —
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Expires: 1999-12-13
Abstract
Abstract A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically indifferent core, a first layer thereon containing the glycoside and a second layer containing a polymer insoluble in gastric juice and soluble in intestinal juice, a process for preparing such preparation and a method of treatment employing the same.
Inventors
- 👤 Curt Henry Appelgren
- 👤 Conny Börje Bogentoft
- 👤 John Albert Sjörgren
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 19:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
104 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material,and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 2
Dependent Claim
104 words
A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material,and on said core a first layer made up of a composition comprising the cardiac glycoside, and thereon a second layer comprising an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 3
Dependent Claim
31 words
A solid pharmaceutical preparation according to claim 1, characterized in that each of the first layer and the second layer is a'layer applied by spraying a solution of the components thereof.
Claim 4
Dependent Claim
35 words
A pharmaceutical preparation in accordance with claim 1 or 2 characterized in that said first layer further comprises a water soluble polymer having the ability to increase the solubility or releasability of the cardiac glycoside.
Claim 5
Dependent Claim
117 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preoaration is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a first layer made up of a composition comprising the cardiac glycoside, whereupon the bodies comprising said core and first layer are provided with a second layer comprising an anionic carboxylic polymer being 'difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 6
Dependent Claim
117 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, characterized in that said pharmaceutical preoaration is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a first layer made up of a composition comprising the cardiac glycoside, whereupon the bodies comprising said core and first layer are provided with a second layer comprising an anionic carboxylic polymer being 'difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 7
Dependent Claim
29 words
A process according to claim 4, characterized in that each of the first and the second layer is applied by adding a solution of the components of the layer.
Claim 8
Dependent Claim
15 words
A process according to claim 5, characterized in that each solution is applied by spraying.
Claim 9
Dependent Claim
24 words
A process according to claim 5 or 6, characterized in that the first and the second layer are applied in a fluid bed apparatus.
References Cited (Backward Citations)
No citation records indexed.
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